Mycobacterial components responsible for the induction of a chronic immunological inflammatory response in rabbit lungs.
Fractions of the tubercle bacillus were examined for their capacity to produce an allergic pulmonary granulomatous response in rabbits. We found that emulsions containing old tuberculin and even old tuberculin alone in an emulsion could induce a pulmonary inflammatory reaction comparable in intensity to that produced with killed BCG. Emulsions lacking old tuberculin failed to produce an allergic pulmonary inflammatory response. The significance of these results in relation to immunological and nonimmunological chronic inflammation is discussed.
17 references, click to expand
-
Role of adjuvants in the production of delayed hypersensitivity.Br Med Bull. 1967 Jan;23(1):39-45 PMID: 5342377
-
Relationship of BCG-induced pulmonary delayed hypersensitivity to accelerated granuloma formation in rabbit lungs: effect of cortisone acetate.Infect Immun. 1973 May;7(5):764-70 PMID: 4797184
-
Migratory response of granulomatous alveolar cells from BCG-sensitized rabbits.J Immunol. 1970 Jul;105(1):227-37 PMID: 5425345
-
Chemical factors involved in the induction of infectious allergy.Experientia. 1950 Nov 15;6(11):410-9 PMID: 14793532
-
Role of cord factor (trehalose-6,6'-dimycolate) in allergic granuloma formation in rabbits.Infect Immun. 1972 Jul;6(1):5-8 PMID: 4564153
-
Ribonucleic acid, deoxyribonucleic acid, and protein content of cells of different ages of Mycobacterium tuberculosis and the ralationship to immunogenicity.J Bacteriol. 1968 Feb;95(2):272-9 PMID: 4966539
-
Changes in morphology and in lysozyme content of free alveolar cells after the intravenous injection of killed BCG in oil.J Reticuloendothel Soc. 1968 Feb;5(1):33-53 PMID: 5650599
-
Effect of antimacrophage serum on dermal tuberculin sensitivity and allergic pulmonary granuloma formation in rabbits.Infect Immun. 1970 Dec;2(6):810-4 PMID: 16557920
-
A study of macrophages and epitheloid-like cells from granulomatous (BCG-induced) lungs of rabbits.J Immunol. 1962 Nov;89:745-51 PMID: 13936993
-
Studies of a biochemical lesion in experimental tuberculosis in mice. V. Further study on a toxic lipid fraction in firmly bound lipids.Am Rev Respir Dis. 1967 Sep;96(3):460-8 PMID: 4292304
-
Granuloma formation induced in mice by chemically defined mycobacterial fractions.J Bacteriol. 1969 Oct;100(1):95-102 PMID: 4981067
-
Granulomatous hypersensitivity to trehalose-6,6'-dimycolate (cord factor) in mice infected with BCG.Infect Immun. 1973 Apr;7(4):631-8 PMID: 4586862
-
Acute granulomatous response produced in mice by trehalose-6,6-dimycolate.J Bacteriol. 1968 Oct;96(4):958-61 PMID: 4971895
-
Studies on pulmonary alveolar macrophages from the normal rabbit: a technique to procure them in a high state of purity.J Immunol. 1961 Feb;86:128-32 PMID: 13727273
-
DISSOCIATION OF TUBERCULIN HYPERSENSITIVITY AS MEDIATOR FOR AN ACCELERATED PULMONARY GRANULOMATOUS RESPONSE IN RABBITS.J Immunol. 1964 Sep;93:433-8 PMID: 14218602
-
Antibody formation to trehalose-6,6'-dimycolate (cord factor) of Mycobacterium tuberculosis.Infect Immun. 1972 Feb;5(2):203-12 PMID: 4117880
-
Specificity of a BCG-induced pulmonary granulomatous response in rabbits.Infect Immun. 1973 May;7(5):743-6 PMID: 4764403
Contact
No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong
Qilu Normal University · Genelibs Bioinformatics Lab
750 Shunhua Rd, Jinan
2F, Bldg F, University Science Park
Tel: 0531-88819269
WeChat Official Account
Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.
Business Email
E-mail: product@genelibs.com
Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2
