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PMID: 33804866 Published · epublish English Journal Article Review

Co-Transcriptional RNA Processing in Plants: Exploring from the Perspective of Polyadenylation.

International journal of molecular sciences ·Vol. 22 ·No. 7 ·2021-03-24

Yang J, Cao Y, Ma L

Abstract

Most protein-coding genes in eukaryotes possess at least two poly(A) sites, and alternative polyadenylation is considered a contributing factor to transcriptomic and proteomic diversity. Following transcription, a nascent RNA usually undergoes capping, splicing, cleavage, and polyadenylation, resulting in a mature messenger RNA (mRNA); however, increasing evidence suggests that transcription and RNA processing are coupled. Plants, which must produce rapid responses to environmental changes because of their limited mobility, exhibit such coupling. In this review, we summarize recent advances in our understanding of the coupling of transcription with RNA processing in plants, and we describe the possible spatial environment and important proteins involved. Moreover, we describe how liquid-liquid phase separation, mediated by the C-terminal domain of RNA polymerase II and RNA processing factors with intrinsically disordered regions, enables efficient co-transcriptional mRNA processing in plants.

Keywords
RNA processing coupling regulation gene expression liquid–liquid phase separation (LLPS) plant polyadenylation transcription
MeSH Terms
Gene Expression Regulation, Plant Polyadenylation RNA, Messenger/genetics,metabolism RNA, Plant/genetics,metabolism Transcription, Genetic
Chemicals
RNA, Messenger RNA, Plant
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Yang Jing ORCID
College of Life Sciences, Capital Normal University, Beijing 100048, China.
Cao Ying
College of Life Sciences, Capital Normal University, Beijing 100048, China.
Ma Ligeng
College of Life Sciences, Capital Normal University, Beijing 100048, China.
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Article Info
Journal
International journal of molecular sciences
Abbr.
Int J Mol Sci
ISSN
1422-0067
DOI
10.3390/ijms22073300
Published
2021-03-24
Epub
2021-00-24
Language
English
Region
Switzerland
NLM ID
101092791
PMCID
PMC8037041
Subset
IM
External Links
PubMed source DOI: 10.3390/ijms22073300 PMC Full Text View journal details
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