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PMID: 3299057 Published · ppublish English Comparative Study Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

DNA sequence encoding the amino-terminal region of the human c-src protein: implications of sequence divergence among src-type kinase oncogenes.

Molecular and cellular biology ·Vol. 7 ·No. 5 ·1987-05-00 ·Pages 1978-83

Tanaka A, Gibbs CP, Arthur RR, Anderson SK, Kung HJ, Fujita DJ

Abstract

We sequenced the 5'-coding region of the human c-src gene, exons 2 through 5, corresponding to one-third of the human c-src protein consisting of 536 amino acids. Sequence analysis of the src type of protein kinases revealed that the amino-terminal region encoded by exon 2 contains sequences specific for the src proteins and raised the possibility that this region is involved in the recognition of a src-specific substrate(s) or receptor(s).

MeSH Terms
Amino Acid Sequence Animals Base Sequence Chickens Genes Humans Introns Oncogenes Protein-Tyrosine Kinases/genetics Proto-Oncogene Proteins/genetics RNA Splicing Sequence Homology, Nucleic Acid
Chemicals
Proto-Oncogene Proteins Protein-Tyrosine Kinases
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
Tanaka A
Gibbs C P
Arthur R R
Anderson S K
Kung H J
Fujita D J
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49 references, click to expand
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Article Info
Journal
Molecular and cellular biology
Abbr.
Mol Cell Biol
ISSN
0270-7306
DOI
10.1128/mcb.7.5.1978-1983.1987
Published
1987-05-00
Pages
1978-83
Language
English
Region
United States
NLM ID
8109087
PMCID
PMC365305
Subset
IM
Grants
NCI NIH HHS · CA38659 · United States
Databases
GENBANK
M16237, M16243, M16244, M16245
External Links
PubMed source DOI: 10.1128/mcb.7.5.1978-1983.1987 PMC Full Text View journal details
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