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PMID: 25443494 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

Epigenomic regulation of host-microbiota interactions.

Trends in immunology ·Vol. 35 ·No. 11 ·2014-11-00 ·Pages 518-25

Alenghat T, Artis D

Abstract

The trillions of beneficial commensal microorganisms that normally reside in the gastrointestinal tract have emerged as a critical source of environmentally-derived stimuli that can impact health and disease. However, the underlying cellular and molecular mechanisms that recognize commensal bacteria-derived signals and regulate mammalian homeostasis are just beginning to be defined. Highly coordinated epigenomic modifications allow mammals to alter the transcriptional program of a cell in response to environmental cues. These modifications may play a key role in regulating the dynamic relationship between mammals and their microbiota. We review recent advances in understanding the interplay between the microbiota and mammalian epigenomic pathways, and highlight emerging findings that implicate a central role for histone deacetylases (HDACs) in orchestrating host-microbiota interactions.

MeSH Terms
Animals Blood Cells/metabolism Cellular Microenvironment Epigenesis, Genetic Epigenomics Gastrointestinal Tract/microbiology,physiology Gene Expression Regulation Gene-Environment Interaction Histone Deacetylases/metabolism Homeostasis Host-Pathogen Interactions Humans Intestinal Mucosa/immunology,metabolism,microbiology Microbiota
Chemicals
Histone Deacetylases
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Alenghat Theresa
Division of Immunobiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA. Electronic address: theresa.alenghat@cchmc.org.
Artis David
Weill Cornell Medical College, Cornell University, New York, NY 10022, USA. Electronic address: dartis@med.cornell.edu.
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Article Info
Journal
Trends in immunology
Abbr.
Trends Immunol
ISSN
1471-4981
DOI
10.1016/j.it.2014.09.007
Email
theresa.alenghat@cchmc.org
dartis@med.cornell.edu
Published
2014-11-00
Epub
2014-00-22
Pages
518-25
Language
English
Region
England
NLM ID
100966032
PMCID
PMC4254645
Subset
IM
Grants
NIAID NIH HHS · R01 AI074878 · United States
NIAID NIH HHS · R01 AI095466 · United States
NIAID NIH HHS · AI061570 · United States
NIAID NIH HHS · P01 AI106697 · United States
NIAID NIH HHS · AI102942 · United States
NIAID NIH HHS · AI106697 · United States
NIAID NIH HHS · AI074878 · United States
NIAID NIH HHS · AI087990 · United States
NIAID NIH HHS · R01 AI102942 · United States
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NIAID NIH HHS · AI095608 · United States
NIDDK NIH HHS · K08 DK093784 · United States
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NIAID NIH HHS · U01 AI095608 · United States
NIAID NIH HHS · R01 AI061570 · United States
NIAID NIH HHS · R01 AI097333 · United States
NIAID NIH HHS · AI095466 · United States
NIAID NIH HHS · AI097333 · United States
External Links
PubMed source DOI: 10.1016/j.it.2014.09.007 PMC Full Text View journal details
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