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PMID: 22261928 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

Metaboloepigenetics: interrelationships between energy metabolism and epigenetic control of gene expression.

Journal of cellular physiology ·Vol. 227 ·No. 9 ·2012-09-00 ·Pages 3169-77

Donohoe DR, Bultman SJ

Abstract

Diet and energy metabolism affect gene expression, which influences human health and disease. Here, we discuss the role of epigenetics as a mechanistic link between energy metabolism and control of gene expression. A number of key energy metabolites including SAM, acetyl-CoA, NAD(+), and ATP serve as essential co-factors for many, perhaps most, epigenetic enzymes that regulate DNA methylation, posttranslational histone modifications, and nucleosome position. The relative abundance of these energy metabolites allows a cell to sense its energetic state. And as co-factors, energy metabolites act as rheostats to modulate the activity of epigenetic enzymes and upregulate/downregulate transcription as appropriate to maintain homeostasis.

MeSH Terms
Acetyl Coenzyme A/metabolism Adenosine Triphosphate/metabolism DNA Methylation/genetics Diet Energy Metabolism Epigenesis, Genetic/genetics Gene Expression Regulation Histones/genetics,metabolism Humans Metabolomics NAD/metabolism Protein Processing, Post-Translational/genetics S-Adenosylmethionine/genetics,metabolism
Chemicals
Histones NAD Acetyl Coenzyme A S-Adenosylmethionine Adenosine Triphosphate
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Donohoe Dallas R
Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA.
Bultman Scott J
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Article Info
Journal
Journal of cellular physiology
Abbr.
J Cell Physiol
ISSN
1097-4652
DOI
10.1002/jcp.24054
Published
2012-09-00
Pages
3169-77
Language
English
Region
United States
NLM ID
0050222
PMCID
PMC3338882
Subset
IM
Grants
NCI NIH HHS · R01 CA125237 · United States
NCI NIH HHS · R01 CA125237-05 · United States
NCI NIH HHS · CA125237 · United States
External Links
PubMed source DOI: 10.1002/jcp.24054 PMC Full Text View journal details
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