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PMID: 20299549 Published · ppublish English Journal Article Research Support, N.I.H., Extramural

Heritable individual-specific and allele-specific chromatin signatures in humans.

Science (New York, N.Y.) ·Vol. 328 ·No. 5975 ·2010-04-09 ·Pages 235-9

McDaniell R, Lee BK, Song L, Liu Z, Boyle AP, Erdos MR, Scott LJ, Morken MA, Kucera KS, Battenhouse A, Keefe D, Collins FS, Willard HF, Lieb JD, Furey TS, Crawford GE, Iyer VR, Birney E

Abstract

The extent to which variation in chromatin structure and transcription factor binding may influence gene expression, and thus underlie or contribute to variation in phenotype, is unknown. To address this question, we cataloged both individual-to-individual variation and differences between homologous chromosomes within the same individual (allele-specific variation) in chromatin structure and transcription factor binding in lymphoblastoid cells derived from individuals of geographically diverse ancestry. Ten percent of active chromatin sites were individual-specific; a similar proportion were allele-specific. Both individual-specific and allele-specific sites were commonly transmitted from parent to child, which suggests that they are heritable features of the human genome. Our study shows that heritable chromatin status and transcription factor binding differ as a result of genetic variation and may underlie phenotypic variation in humans.

MeSH Terms
Alleles Binding Sites Blacks CCCTC-Binding Factor Cell Line Chromatin/chemistry,genetics,metabolism Chromatin Immunoprecipitation Chromosomes, Human/genetics,metabolism Chromosomes, Human, X/genetics,metabolism Deoxyribonuclease I/metabolism Female Gene Expression Regulation Genetic Variation Humans Male Nuclear Family Polymorphism, Single Nucleotide Protein Binding Regulatory Elements, Transcriptional Repressor Proteins/metabolism Sequence Analysis, DNA Transcription Factors/metabolism Whites X Chromosome Inactivation
Chemicals
CCCTC-Binding Factor CTCF protein, human Chromatin Repressor Proteins Transcription Factors Deoxyribonuclease I
Authors & Affiliations
18 authors, click to expand affiliations / ORCID
McDaniell Ryan
Center for Systems and Synthetic Biology, Institute for Cellular and Molecular Biology, Section of Molecular Genetics and Microbiology, University of Texas, Austin, TX 78712, USA.
Lee Bum-Kyu
Song Lingyun
Liu Zheng
Boyle Alan P
Erdos Michael R
Scott Laura J
Morken Mario A
Kucera Katerina S
Battenhouse Anna
Keefe Damian
Collins Francis S
Willard Huntington F
Lieb Jason D
Furey Terrence S
Crawford Gregory E
Iyer Vishwanath R
Birney Ewan
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Article Info
Journal
Science (New York, N.Y.)
Abbr.
Science
ISSN
1095-9203
Published
2010-04-09
Epub
2010-00-18
Pages
235-9
Language
English
Region
United States
NLM ID
0404511
PMCID
PMC2929018
Subset
IM
Grants
NHGRI NIH HHS · U54 HG004563 · United States
NHGRI NIH HHS · U54 HG004563-03 · United States
Intramural NIH HHS · Z01 HG000024 · United States
Intramural NIH HHS · Z01 HG000024-13 · United States
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