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PMID: 25172617 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

Modulation of immune development and function by intestinal microbiota.

Trends in immunology ·Vol. 35 ·No. 11 ·2014-11-00 ·Pages 507-17

Kabat AM, Srinivasan N, Maloy KJ

Abstract

The immune system must constantly monitor the gastrointestinal tract for the presence of pathogens while tolerating trillions of commensal microbiota. It is clear that intestinal microbiota actively modulate the immune system to maintain a mutually beneficial relation, but the mechanisms that maintain homeostasis are not fully understood. Recent advances have begun to shed light on the cellular and molecular factors involved, revealing that a range of microbiota derivatives can influence host immune functions by targeting various cell types, including intestinal epithelial cells, mononuclear phagocytes, innate lymphoid cells, and B and T lymphocytes. Here, we review these findings, highlighting open questions and important challenges to overcome in translating this knowledge into new therapies for intestinal and systemic immune disorders.

Keywords
commensals immune regulation microbiota mucosal immunity
MeSH Terms
Animals Cell Differentiation Homeostasis Humans Immunity, Innate Immunity, Mucosal Immunoglobulin A, Secretory/biosynthesis,immunology Immunomodulation Intestinal Mucosa/immunology,metabolism,microbiology Intestines/immunology,microbiology Lymphocytes/cytology,immunology,metabolism Microbiota Phagocytes/immunology,metabolism,microbiology Signal Transduction
Chemicals
Immunoglobulin A, Secretory
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Kabat Agnieszka M
Sir William Dunn School of Pathology, University of Oxford, Oxford, UK.
Srinivasan Naren
Sir William Dunn School of Pathology, University of Oxford, Oxford, UK; Immunobiology Laboratory, Cancer Research UK, London Research Institute, London, UK.
Maloy Kevin J
Sir William Dunn School of Pathology, University of Oxford, Oxford, UK. Electronic address: kevin.maloy@path.ox.ac.uk.
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Article Info
Journal
Trends in immunology
Abbr.
Trends Immunol
ISSN
1471-4981
DOI
10.1016/j.it.2014.07.010
Email
kevin.maloy@path.ox.ac.uk
Published
2014-11-00
Epub
2014-00-27
Pages
507-17
Language
English
Region
England
NLM ID
100966032
PMCID
PMC6485503
Subset
IM
Grants
Wellcome Trust · United Kingdom
Wellcome Trust · 102972 · United Kingdom
External Links
PubMed source DOI: 10.1016/j.it.2014.07.010 PMC Full Text View journal details
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