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PMID: 22674328 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Interactions between commensal fungi and the C-type lectin receptor Dectin-1 influence colitis.

Science (New York, N.Y.) ·Vol. 336 ·No. 6086 ·2012-06-08 ·Pages 1314-7

Iliev ID, Funari VA, Taylor KD, Nguyen Q, Reyes CN, Strom SP, Brown J, Becker CA, Fleshner PR, Dubinsky M, Rotter JI, Wang HL, McGovern DP, Brown GD, Underhill DM

Abstract

The intestinal microflora, typically equated with bacteria, influences diseases such as obesity and inflammatory bowel disease. Here, we show that the mammalian gut contains a rich fungal community that interacts with the immune system through the innate immune receptor Dectin-1. Mice lacking Dectin-1 exhibited increased susceptibility to chemically induced colitis, which was the result of altered responses to indigenous fungi. In humans, we identified a polymorphism in the gene for Dectin-1 (CLEC7A) that is strongly linked to a severe form of ulcerative colitis. Together, our findings reveal a eukaryotic fungal community in the gut (the "mycobiome") that coexists with bacteria and substantially expands the repertoire of organisms interacting with the intestinal immune system to influence health and disease.

MeSH Terms
Animals Antibodies, Fungal/blood Candida tropicalis/immunology,isolation & purification,pathogenicity,physiology Colitis, Ulcerative/chemically induced,immunology,microbiology Colon/immunology,microbiology Colony Count, Microbial Dextran Sulfate Disease Susceptibility Female Fungi/classification,immunology,isolation & purification,physiology Haplotypes Humans Immunity, Innate Immunity, Mucosal Intestinal Mucosa/immunology,microbiology Intestines/immunology,microbiology Lectins, C-Type/deficiency,genetics,metabolism Metagenome Mice Mice, Inbred C57BL Polymorphism, Single Nucleotide
Chemicals
Antibodies, Fungal CLEC7A protein, human Lectins, C-Type dectin 1 Dextran Sulfate
Authors & Affiliations
15 authors, click to expand affiliations / ORCID
Iliev Iliyan D
Inflammatory Bowel and Immunobiology Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
Funari Vincent A
Taylor Kent D
Nguyen Quoclinh
Reyes Christopher N
Strom Samuel P
Brown Jordan
Becker Courtney A
Fleshner Phillip R
Dubinsky Marla
Rotter Jerome I
Wang Hanlin L
McGovern Dermot P B
Brown Gordon D
Underhill David M
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Article Info
Journal
Science (New York, N.Y.)
Abbr.
Science
ISSN
1095-9203
DOI
10.1126/science.1221789
Published
2012-06-08
Epub
2012-00-06
Pages
1314-7
Language
English
Region
United States
NLM ID
0404511
PMCID
PMC3432565
Subset
IM
Grants
NCRR NIH HHS · UL1 RR033176 · United States
Wellcome Trust · 086558 · United Kingdom
NCRR NIH HHS · UL1RR033176 · United States
NCATS NIH HHS · UL1 TR000124 · United States
NIAID NIH HHS · R01 AI071116 · United States
NIDDK NIH HHS · P01 DK046763 · United States
NIDDK NIH HHS · R01 DK093426 · United States
NIAID NIH HHS · AI071116 · United States
NIDDK NIH HHS · P01-DK046763 · United States
Corrections
CommentIn
PMID: 22704612
CommentIn
PMID: 22728523
External Links
PubMed source DOI: 10.1126/science.1221789 PMC Full Text View journal details
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