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PMID: 17291293 Published · ppublish English Journal Article Review

Epithelia: lymphocyte interactions in the gut.

Immunological reviews ·Vol. 215 ·2007-02-00 ·Pages 243-53

Dahan S, Roth-Walter F, Arnaboldi P, Agarwal S, Mayer L

Abstract

The mucosal immune system is governed by a unique set of rules and regulations. The local microenvironment dictates the necessity for these differences. The intestinal epithelial cell (IEC) sits at the interface between an antigen-rich lumen and a lymphocyte-rich lamina propria (LP). The cross talk that occurs between these compartments serves to maintain intestinal homeostasis. IECs have the capacity to talk to LP lymphocytes, activating populations of unique regulatory T cells. These cells have the capacity to talk back to the epithelium, influencing epithelial cell growth and differentiation. This review looks at this cross talk and places it in the context of mucosal immunoregulation.

MeSH Terms
Animals Antigen-Presenting Cells/immunology,metabolism Cell Communication/immunology Epithelial Cells/immunology,metabolism Humans Immunity, Mucosal Intestinal Mucosa/cytology,immunology Lymphocyte Activation/immunology Receptor Cross-Talk/immunology T-Lymphocytes/immunology,metabolism
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Dahan Stephanie
Immunobiology Center, Mount Sinai School of Medicine, New York, NY 10029, USA.
Roth-Walter Franziska
Arnaboldi Paul
Agarwal Shradha
Mayer Lloyd
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Article Info
Journal
Immunological reviews
Abbr.
Immunol Rev
ISSN
0105-2896
DOI
10.1111/j.1600-065X.2006.00484.x
Published
2007-02-00
Pages
243-53
Language
English
Region
England
NLM ID
7702118
PMCID
PMC3864677
Subset
IM
Grants
NIAID NIH HHS · R01 AI023504 · United States
NIAID NIH HHS · R01 AI023504-11 · United States
External Links
PubMed source DOI: 10.1111/j.1600-065X.2006.00484.x PMC Full Text View journal details
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