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PMID: 19065135 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

The many roles of histone deacetylases in development and physiology: implications for disease and therapy.

Nature reviews. Genetics ·Vol. 10 ·No. 1 ·2009-01-00 ·Pages 32-42

Haberland M, Montgomery RL, Olson EN

Abstract

Histone deacetylases (HDACs) are part of a vast family of enzymes that have crucial roles in numerous biological processes, largely through their repressive influence on transcription. The expression of many HDAC isoforms in eukaryotic cells raises questions about their possible specificity or redundancy, and whether they control global or specific programmes of gene expression. Recent analyses of HDAC knockout mice have revealed highly specific functions of individual HDACs in development and disease. Mutant mice lacking individual HDACs are a powerful tool for defining the functions of HDACs in vivo and the molecular targets of HDAC inhibitors in disease.

MeSH Terms
Acetylation Animals Cardiomegaly/metabolism,therapy Chondrocytes/metabolism Enzyme Inhibitors/therapeutic use Gene Expression Regulation, Developmental Histone Deacetylase Inhibitors Histone Deacetylases/genetics,physiology Histones/metabolism Mice Models, Biological Muscle, Skeletal/metabolism
Chemicals
Enzyme Inhibitors Histone Deacetylase Inhibitors Histones Histone Deacetylases
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Haberland Michael
Department of Molecular Biology, University of Texas Southwestern Medical Center, 6000 Harry Hines Boulevard, Dallas, Texas 75390-9148, USA.
Montgomery Rusty L
Olson Eric N
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Article Info
Journal
Nature reviews. Genetics
Abbr.
Nat Rev Genet
ISSN
1471-0064
DOI
10.1038/nrg2485
Published
2009-01-00
Pages
32-42
Language
English
Region
England
NLM ID
100962779
PMCID
PMC3215088
Subset
IM
Grants
NHLBI NIH HHS · R01 HL083371-05 · United States
NHLBI NIH HHS · R01 HL083371 · United States
NHLBI NIH HHS · R01 HL083371-02 · United States
NHLBI NIH HHS · R01 HL083371-01 · United States
NHLBI NIH HHS · R01 HL083371-04W1 · United States
NHLBI NIH HHS · R01 HL083371-03 · United States
NHLBI NIH HHS · R01 HL093039 · United States
NHLBI NIH HHS · R01 HL083371-04 · United States
External Links
PubMed source DOI: 10.1038/nrg2485 PMC Full Text View journal details
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