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PMID: 24172333 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Review

MicroRNAs and other non-coding RNAs as targets for anticancer drug development.

Nature reviews. Drug discovery ·Vol. 12 ·No. 11 ·2013-11-00 ·Pages 847-65

Ling H, Fabbri M, Calin GA

Abstract

The first cancer-targeted microRNA (miRNA) drug - MRX34, a liposome-based miR-34 mimic - entered Phase I clinical trials in patients with advanced hepatocellular carcinoma in April 2013, and miRNA therapeutics are attracting special attention from both academia and biotechnology companies. Although miRNAs are the most studied non-coding RNAs (ncRNAs) to date, the importance of long non-coding RNAs (lncRNAs) is increasingly being recognized. Here, we summarize the roles of miRNAs and lncRNAs in cancer, with a focus on the recently identified novel mechanisms of action, and discuss the current strategies in designing ncRNA-targeting therapeutics, as well as the associated challenges.

MeSH Terms
Antineoplastic Agents/pharmacology,therapeutic use Drug Discovery/methods Humans MicroRNAs/drug effects,therapeutic use Models, Biological Molecular Targeted Therapy/methods Neoplasms/drug therapy RNA, Untranslated/drug effects,therapeutic use
Chemicals
Antineoplastic Agents MicroRNAs RNA, Untranslated
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Ling Hui
1] Experimental Therapeutics and Leukemia Department, MD Anderson Cancer Center, University of Texas, Houston, Texas 77030, USA. [2].
Fabbri Muller
Calin George A
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Article Info
Journal
Nature reviews. Drug discovery
Abbr.
Nat Rev Drug Discov
ISSN
1474-1784
DOI
10.1038/nrd4140
Published
2013-11-00
Pages
847-65
Language
English
Region
England
NLM ID
101124171
PMCID
PMC4548803
Subset
IM
Grants
NCI NIH HHS · P50 CA097007 · United States
NCI NIH HHS · P30CA014089 · United States
NCI NIH HHS · R01 CA135444 · United States
NCI NIH HHS · P30 CA014089 · United States
NCI NIH HHS · CA135444 · United States
NCI NIH HHS · P50 CA100632 · United States
External Links
PubMed source DOI: 10.1038/nrd4140 PMC Full Text View journal details
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