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PMID: 15944707 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S.

A microRNA polycistron as a potential human oncogene.

Nature ·Vol. 435 ·No. 7043 ·2005-06-09 ·Pages 828-33

He L, Thomson JM, Hemann MT, Hernando-Monge E, Mu D, Goodson S, Powers S, Cordon-Cardo C, Lowe SW, Hannon GJ, Hammond SM

Abstract

To date, more than 200 microRNAs have been described in humans; however, the precise functions of these regulatory, non-coding RNAs remains largely obscure. One cluster of microRNAs, the mir-17-92 polycistron, is located in a region of DNA that is amplified in human B-cell lymphomas. Here we compared B-cell lymphoma samples and cell lines to normal tissues, and found that the levels of the primary or mature microRNAs derived from the mir-17-92 locus are often substantially increased in these cancers. Enforced expression of the mir-17-92 cluster acted with c-myc expression to accelerate tumour development in a mouse B-cell lymphoma model. Tumours derived from haematopoietic stem cells expressing a subset of the mir-17-92 cluster and c-myc could be distinguished by an absence of apoptosis that was otherwise prevalent in c-myc-induced lymphomas. Together, these studies indicate that non-coding RNAs, specifically microRNAs, can modulate tumour formation, and implicate the mir-17-92 cluster as a potential human oncogene.

MeSH Terms
Animals Cell Line, Tumor Disease Models, Animal Gene Expression Profiling Gene Expression Regulation, Neoplastic Genes/genetics Genes, myc/genetics Humans Lymphoma, B-Cell/genetics Mice MicroRNAs/genetics Molecular Sequence Data Multigene Family/genetics Oncogenes/genetics Phenotype Proto-Oncogene Proteins c-myc/genetics,metabolism RNA, Messenger/genetics,metabolism
Chemicals
MicroRNAs Proto-Oncogene Proteins c-myc RNA, Messenger
Authors & Affiliations
11 authors, click to expand affiliations / ORCID
He Lin
Cold Spring Harbor Laboratory, Watson School of Biological Sciences, 1 Bungtown Road, Cold Spring Harbor, New York 11724, USA.
Thomson J Michael
Hemann Michael T
Hernando-Monge Eva
Mu David
Goodson Summer
Powers Scott
Cordon-Cardo Carlos
Lowe Scott W
Hannon Gregory J
Hammond Scott M
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Article Info
Journal
Nature
Abbr.
Nature
ISSN
1476-4687
DOI
10.1038/nature03552
Published
2005-06-09
Pages
828-33
Language
English
Region
England
NLM ID
0410462
PMCID
PMC4599349
Subset
IM
Grants
NCI NIH HHS · P01 CA087497 · United States
NCI NIH HHS · P30 CA008748 · United States
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GENBANK
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Corrections
CommentIn
PMID: 15944682
CommentIn
PMID: 16009126
External Links
PubMed source DOI: 10.1038/nature03552 PMC Full Text View journal details
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