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PMID: 22266873 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Review

Long non-coding RNAs and cancer: a new frontier of translational research?

Oncogene ·Vol. 31 ·No. 43 ·2012-10-25 ·Pages 4577-87

Spizzo R, Almeida MI, Colombatti A, Calin GA

Abstract

Tiling array and novel sequencing technologies have made available the transcription profile of the entire human genome. However, the extent of transcription and the function of genetic elements that occur outside of protein-coding genes, particularly those involved in disease, are still a matter of debate. In this review, we focus on long non-coding RNAs (lncRNAs) that are involved in cancer. We define lncRNAs and present a cancer-oriented list of lncRNAs, list some tools (for example, public databases) that classify lncRNAs or that scan genome spans of interest to find whether known lncRNAs reside there, and describe some of the functions of lncRNAs and the possible genetic mechanisms that underlie lncRNA expression changes in cancer, as well as current and potential future applications of lncRNA research in the treatment of cancer.

MeSH Terms
Humans Neoplasms/genetics RNA, Untranslated/genetics Translational Research, Biomedical
Chemicals
RNA, Untranslated
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Spizzo R
Experimental Oncology, Centro di Riferimento Oncologico, IRCSS-National Cancer Institute, Aviano, PN, Italy.
Almeida M I
Colombatti A
Calin G A
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Article Info
Journal
Oncogene
Abbr.
Oncogene
ISSN
1476-5594
DOI
10.1038/onc.2011.621
Published
2012-10-25
Epub
2012-00-23
Pages
4577-87
Language
English
Region
England
NLM ID
8711562
PMCID
PMC3433647
Subset
IM
Grants
NCI NIH HHS · P50 CA100632 · United States
NCI NIH HHS · R01 CA135444 · United States
NCI NIH HHS · CA135444 · United States
External Links
PubMed source DOI: 10.1038/onc.2011.621 PMC Full Text View journal details
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