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PMID: 20885409 Published · ppublish English Journal Article Review

Targeting microRNAs in cancer: rationale, strategies and challenges.

Nature reviews. Drug discovery ·Vol. 9 ·No. 10 ·2010-10-00 ·Pages 775-89

Garzon R, Marcucci G, Croce CM

Abstract

MicroRNAs (miRNAs) are evolutionarily conserved small non-coding RNAs that regulate gene expression. Early studies have shown that miRNA expression is deregulated in cancer and experimental data indicate that cancer phenotypes can be modified by targeting miRNA expression. Based on these observations, miRNA-based anticancer therapies are being developed, either alone or in combination with current targeted therapies, with the goal to improve disease response and increase cure rates. The advantage of using miRNA approaches is based on its ability to concurrently target multiple effectors of pathways involved in cell differentiation, proliferation and survival. In this Review, we describe the role of miRNAs in tumorigenesis and critically discuss the rationale, the strategies and the challenges for the therapeutic targeting of miRNAs in cancer.

MeSH Terms
Animals Gene Expression Profiling/methods,trends Gene Targeting/methods,trends Humans MicroRNAs/antagonists & inhibitors,metabolism Neoplasms/genetics,therapy
Chemicals
MicroRNAs
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Garzon Ramiro
Division of Haematology and Oncology, Department of Medicine, Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio 43221, USA. ramiro.garzon@osumc.edu
Marcucci Guido
Croce Carlo M
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Article Info
Journal
Nature reviews. Drug discovery
Abbr.
Nat Rev Drug Discov
ISSN
1474-1784
DOI
10.1038/nrd3179
Email
ramiro.garzon@osumc.edu
Published
2010-10-00
Pages
775-89
Language
English
Region
England
NLM ID
101124171
PMCID
PMC3904431
Subset
IM
Grants
NCI NIH HHS · P50 CA140158 · United States
NHLBI NIH HHS · R21 HL104460 · United States
External Links
PubMed source DOI: 10.1038/nrd3179 PMC Full Text View journal details
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