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PMID: 23746253 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Review

Mechanisms for initiating cellular DNA replication.

Annual review of biochemistry ·Vol. 82 ·2013-00-00 ·Pages 25-54

Costa A, Hood IV, Berger JM

Abstract

The initiation of DNA replication represents a committing step to cell proliferation. Appropriate replication onset depends on multiprotein complexes that help properly distinguish origin regions, generate nascent replication bubbles, and promote replisome formation. This review describes initiation systems employed by bacteria, archaea, and eukaryotes, with a focus on comparing and contrasting molecular mechanisms among organisms. Although commonalities can be found in the functional domains and strategies used to carry out and regulate initiation, many key participants have markedly different activities and appear to have evolved convergently. Despite significant advances in the field, major questions still persist in understanding how initiation programs are executed at the molecular level.

MeSH Terms
Archaea/genetics,metabolism Bacteria/genetics,metabolism DNA Replication/genetics DNA-Binding Proteins/genetics,metabolism Eukaryota/genetics,metabolism Humans Peptide Initiation Factors/genetics,metabolism Replication Origin/genetics
Chemicals
DNA-Binding Proteins Peptide Initiation Factors
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Costa Alessandro
Clare Hall Laboratories, London Research Institute, Cancer Research UK, Hertfordshire, EN6 3LD United Kingdom. alessandro.costa@cancer.org.uk
Hood Iris V
Berger James M
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Article Info
Journal
Annual review of biochemistry
Abbr.
Annu Rev Biochem
ISSN
1545-4509
DOI
10.1146/annurev-biochem-052610-094414
Email
alessandro.costa@cancer.org.uk
Published
2013-00-00
Pages
25-54
Language
English
Region
United States
NLM ID
2985150R
PMCID
PMC4696014
Subset
IM
Grants
NCI NIH HHS · P30 CA006973 · United States
NIGMS NIH HHS · R01 GM071747 · United States
Cancer Research UK · United Kingdom
NIGMS NIH HHS · GM071747 · United States
External Links
PubMed source DOI: 10.1146/annurev-biochem-052610-094414 PMC Full Text View journal details
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