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PMID: 20840865 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

Oxidative stress, inflammation, and cancer: how are they linked?

Free radical biology & medicine ·Vol. 49 ·No. 11 ·2010-12-01 ·Pages 1603-16

Reuter S, Gupta SC, Chaturvedi MM, Aggarwal BB

Abstract

Extensive research during the past 2 decades has revealed the mechanism by which continued oxidative stress can lead to chronic inflammation, which in turn could mediate most chronic diseases including cancer, diabetes, and cardiovascular, neurological, and pulmonary diseases. Oxidative stress can activate a variety of transcription factors including NF-κB, AP-1, p53, HIF-1α, PPAR-γ, β-catenin/Wnt, and Nrf2. Activation of these transcription factors can lead to the expression of over 500 different genes, including those for growth factors, inflammatory cytokines, chemokines, cell cycle regulatory molecules, and anti-inflammatory molecules. How oxidative stress activates inflammatory pathways leading to transformation of a normal cell to tumor cell, tumor cell survival, proliferation, chemoresistance, radioresistance, invasion, angiogenesis, and stem cell survival is the focus of this review. Overall, observations to date suggest that oxidative stress, chronic inflammation, and cancer are closely linked.

MeSH Terms
Animals Cell Proliferation Cell Survival/drug effects,radiation effects Cell Transformation, Neoplastic/genetics,metabolism,pathology Drug Resistance, Neoplasm/genetics,immunology Humans Inflammation/complications,etiology,genetics,pathology Models, Biological Neoplasms/blood supply,etiology,genetics,pathology Neovascularization, Pathologic/etiology,genetics,pathology Oxidative Stress/genetics,physiology Signal Transduction/genetics,physiology Tumor Escape/genetics,immunology
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Reuter Simone
Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Gupta Subash C
Chaturvedi Madan M
Aggarwal Bharat B
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Article Info
Journal
Free radical biology & medicine
Abbr.
Free Radic Biol Med
ISSN
1873-4596
DOI
10.1016/j.freeradbiomed.2010.09.006
Published
2010-12-01
Epub
2010-00-16
Pages
1603-16
Language
English
Region
United States
NLM ID
8709159
PMCID
PMC2990475
Subset
IM
Grants
NCI NIH HHS · CA-124787-01A2 · United States
NCI NIH HHS · CA-16672 · United States
NCI NIH HHS · P30 CA016672 · United States
NCI NIH HHS · P01 CA124787 · United States
NCI NIH HHS · P01 CA124787-020002 · United States
NCI NIH HHS · P01 CA091844 · United States
NCI NIH HHS · P01 CA091844-020004 · United States
NCI NIH HHS · P01 CA124787-01A20002 · United States
NCI NIH HHS · P01 CA091844-010004 · United States
NCI NIH HHS · P01 CA124787-030002 · United States
Corrections
CommentIn
PMID: 32813197
External Links
PubMed source DOI: 10.1016/j.freeradbiomed.2010.09.006 PMC Full Text View journal details
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