Regulation of the Wnt/beta-catenin pathway by redox signaling.

Developmental cell ·Vol. 10 ·No. 6 ·2006-06-00 ·Pages 687-8

Korswagen HC

Abstract

Although it is well established that reactive oxygen species (ROS) can function as intracellular messengers, the mechanism of ROS dependent signaling is largely unknown (Rhee et al.,2005). In a recent paper in Nature Cell Biology, Funato et al. (2006) demonstrate that ROS can modulate signaling by the Wnt/beta-catenin pathway. This work provides interesting new insight into cross-talk between redox and Wnt/beta-catenin signaling in normal physiology and cancer.

MeSH Terms

Adaptor Proteins, Signal Transducing/metabolism Animals COS Cells Cells, Cultured Chlorocebus aethiops Dishevelled Proteins Hydrogen Peroxide/pharmacology Mice NIH 3T3 Cells Nuclear Proteins/metabolism Oxidation-Reduction Oxidoreductases/metabolism Phosphoproteins/metabolism Phosphorylation Protein Binding Signal Transduction Thioredoxins/metabolism Wnt Proteins/antagonists & inhibitors Xenopus beta Catenin/antagonists & inhibitors

Chemicals

Adaptor Proteins, Signal Transducing Dishevelled Proteins Nuclear Proteins Phosphoproteins Wnt Proteins beta Catenin Thioredoxins Hydrogen Peroxide Oxidoreductases nucleoredoxin

Authors & Affiliations

1 authors, click to expand affiliations / ORCID

Korswagen Hendrik C

Hubrecht Laboratory, Netherlands Institute for Developmental Biology, Uppsalalaan 8, 3584 CT Utrecht, The Netherlands.

Article Info

Journal

Developmental cell

Abbr.

Dev Cell

ISSN

1534-5807

DOI

10.1016/j.devcel.2006.05.007

Published

2006-06-00

Pages

687-8

Language

English

Region

United States

NLM ID

101120028

Subset

Corrections

CommentOn

PMID: 16604061

External Links

PubMed source DOI: 10.1016/j.devcel.2006.05.007 View journal details

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Regulation of the Wnt/beta-catenin pathway by redox signaling.

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