Hypoxia and oxidative stress in breast cancer. Oxidative stress: its effects on the growth, metastatic potential and response to therapy of breast cancer.

Breast cancer research : BCR ·Vol. 3 ·No. 5 ·2001-00-00 ·Pages 323-7

Brown NS, Bicknell R

Abstract

Reactive oxygen species (ROS) damage DNA, but the role of ROS in breast carcinoma may not be limited to the mutagenic activity that drives carcinoma initiation and progression. Carcinoma cells in vitro and in vivo are frequently under persistent oxidative stress. In the present review, we outline potential causes of oxygen radical generation within carcinoma cells and explore the possible impact of oxidative stress on the clinical outcome of breast carcinoma.

MeSH Terms

Breast/blood supply Breast Neoplasms/drug therapy,metabolism,pathology Female Humans Neoplasm Metastasis Neovascularization, Pathologic Oxidative Stress Reactive Oxygen Species/metabolism

Chemicals

Reactive Oxygen Species

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Brown N S

Molecular Angiogenesis Laboratory, Imperial Cancer Research Fund, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford, UK.

Bicknell R

References (32)

32 references, click to expand

Thymidine phosphorylase induces carcinoma cell oxidative stress and promotes secretion of angiogenic factors.
Cancer Res. 2000 Nov 15;60(22):6298-302 PMID: 11103787
Oxidative stress and AP-1 activity in tamoxifen-resistant breast tumors in vivo.
J Natl Cancer Inst. 2000 Dec 6;92(23):1926-34 PMID: 11106684
The actin cytoskeleton reorganization induced by Rac1 requires the production of superoxide.
Antioxid Redox Signal. 1999 Spring;1(1):29-43 PMID: 11225730
Metalloproteinases: role in breast carcinogenesis, invasion and metastasis.
Breast Cancer Res. 2000;2(4):252-7 PMID: 11250717
Resistance of human tumor cells in vitro to oxidative cytolysis.
J Clin Invest. 1985 Jul;76(1):80-6 PMID: 2991343
Methionine sulfoxide and the oxidative regulation of plasma proteinase inhibitors.
J Leukoc Biol. 1988 Apr;43(4):365-79 PMID: 2450941
Production of large amounts of hydrogen peroxide by human tumor cells.
Cancer Res. 1991 Feb 1;51(3):794-8 PMID: 1846317
The role of macrophage-derived TNFa in the induction of sublethal tumor cell DNA damage.
Carcinogenesis. 1992 Jan;13(1):77-81 PMID: 1733575
Increased manganese superoxide dismutase expression suppresses the malignant phenotype of human melanoma cells.
Proc Natl Acad Sci U S A. 1993 Apr 1;90(7):3113-7 PMID: 8464931
The metabolism of 17 beta-estradiol by lactoperoxidase: a possible source of oxidative stress in breast cancer.
Carcinogenesis. 1994 Nov;15(11):2637-43 PMID: 7955118
Sublethal oxidative stress inhibits tumor cell adhesion and enhances experimental metastasis of murine mammary carcinoma.
Clin Exp Metastasis. 1995 Jan;13(1):16-22 PMID: 7820952
Persistent oxidative stress in cancer.
FEBS Lett. 1995 Jan 16;358(1):1-3 PMID: 7821417
Superoxide and hydrogen peroxide in relation to mammalian cell proliferation.
Free Radic Biol Med. 1995 Apr;18(4):775-94 PMID: 7750801
Cellular levels of thioredoxin associated with drug sensitivity to cisplatin, mitomycin C, doxorubicin, and etoposide.
Cancer Res. 1995 Oct 1;55(19):4293-6 PMID: 7671238
Damage to DNA by reactive oxygen and nitrogen species: role in inflammatory disease and progression to cancer.
Biochem J. 1996 Jan 1;313 ( Pt 1):17-29 PMID: 8546679
Augmentation of cytokine-induced nitric oxide synthesis by hydrogen peroxide.
Am J Physiol. 1996 Jul;271(1 Pt 1):L114-20 PMID: 8760140
Regulation of reactive-oxygen-species generation in fibroblasts by Rac1.
Biochem J. 1996 Sep 1;318 ( Pt 2):379-82 PMID: 8809022
Glucose deprivation-induced oxidative stress in human tumor cells. A fundamental defect in metabolism?
Ann N Y Acad Sci. 2000;899:349-62 PMID: 10863552
Heat shock protein 27 plays two distinct roles in controlling human breast cancer cell migration on laminin-5.
Mol Cell Biol Res Commun. 1999 Jun;1(3):196-202 PMID: 10425226
Coenzyme Q10 concentrations and antioxidant status in tissues of breast cancer patients.
Clin Biochem. 2000 Jun;33(4):279-84 PMID: 10936586
Reactive oxygen species generated at mitochondrial complex III stabilize hypoxia-inducible factor-1alpha during hypoxia: a mechanism of O2 sensing.
J Biol Chem. 2000 Aug 18;275(33):25130-8 PMID: 10833514
Nonhypoxic pathway mediates the induction of hypoxia-inducible factor 1alpha in vascular smooth muscle cells.
J Biol Chem. 2000 Sep 1;275(35):26765-71 PMID: 10837481
Reactive oxygen species produced by macrophage-derived foam cells regulate the activity of vascular matrix metalloproteinases in vitro. Implications for atherosclerotic plaque stability.
J Clin Invest. 1996 Dec 1;98(11):2572-9 PMID: 8958220
Oxidative stress-induced actin reorganization mediated by the p38 mitogen-activated protein kinase/heat shock protein 27 pathway in vascular endothelial cells.
Circ Res. 1997 Mar;80(3):383-92 PMID: 9048659
Mitogenic signaling mediated by oxidants in Ras-transformed fibroblasts.
Science. 1997 Mar 14;275(5306):1649-52 PMID: 9054359
Glucose deprivation-induced cytotoxicity and alterations in mitogen-activated protein kinase activation are mediated by oxidative stress in multidrug-resistant human breast carcinoma cells.
J Biol Chem. 1998 Feb 27;273(9):5294-9 PMID: 9478987
The cellular response to oxidative stress: influences of mitogen-activated protein kinase signalling pathways on cell survival.
Biochem J. 1998 Jul 15;333 ( Pt 2):291-300 PMID: 9657968
The protein thiol metallothionein as an antioxidant and protectant against antineoplastic drugs.
Chem Biol Interact. 1998 Apr 24;111-112:255-62 PMID: 9679559
The activation of protein kinase B by H2O2 or heat shock is mediated by phosphoinositide 3-kinase and not by mitogen-activated protein kinase-activated protein kinase-2.
Biochem J. 1998 Nov 15;336 ( Pt 1):241-6 PMID: 9806907
Tamoxifen induces oxidative stress and apoptosis in oestrogen receptor-negative human cancer cell lines.
Br J Cancer. 1999 Jan;79(2):257-63 PMID: 9888466
Differential regulation of p21 by p53 and Rb in cellular response to oxidative stress.
Mol Carcinog. 1999 Jan;24(1):15-24 PMID: 10029406
Reactive oxygen species participate in mdr1b mRNA and P-glycoprotein overexpression in primary rat hepatocyte cultures.
Carcinogenesis. 1999 Mar;20(3):407-14 PMID: 10190554

Article Info

Journal

Breast cancer research : BCR

Abbr.

Breast Cancer Res

ISSN

1465-5411

DOI

10.1186/bcr315

Published

2001-00-00

Epub

2001-00-23

Pages

323-7

Language

English

Region

England

NLM ID

100927353

PMCID

PMC138696

Subset

External Links

PubMed source DOI: 10.1186/bcr315 PMC Full Text View journal details

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Hypoxia and oxidative stress in breast cancer. Oxidative stress: its effects on the growth, metastatic potential and response to therapy of breast cancer.

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