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PMID: 20303878 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

Immunity, inflammation, and cancer.

Cell ·Vol. 140 ·No. 6 ·2010-03-19 ·Pages 883-99

Grivennikov SI, Greten FR, Karin M

Abstract

Inflammatory responses play decisive roles at different stages of tumor development, including initiation, promotion, malignant conversion, invasion, and metastasis. Inflammation also affects immune surveillance and responses to therapy. Immune cells that infiltrate tumors engage in an extensive and dynamic crosstalk with cancer cells, and some of the molecular events that mediate this dialog have been revealed. This review outlines the principal mechanisms that govern the effects of inflammation and immunity on tumor development and discusses attractive new targets for cancer therapy and prevention.

MeSH Terms
Animals Cell Transformation, Neoplastic/immunology Humans Immune System/cytology Inflammation/immunology,physiopathology Neoplasms/immunology
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Grivennikov Sergei I
Departments of Pharmacology and Pathology, University of California, San Diego, La Jolla, 92093, USA.
Greten Florian R
Karin Michael
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Article Info
Journal
Cell
Abbr.
Cell
ISSN
1097-4172
DOI
10.1016/j.cell.2010.01.025
Published
2010-03-19
Pages
883-99
Language
English
Region
United States
NLM ID
0413066
PMCID
PMC2866629
Subset
IM
Grants
NCI NIH HHS · R01 CA127923-04 · United States
NCI NIH HHS · R01 CA132586-02 · United States
NCI NIH HHS · R01 CA118165 · United States
NIAID NIH HHS · R01 AI043477 · United States
NCI NIH HHS · R01 CA132586 · United States
NIAID NIH HHS · R01 AI043477-13 · United States
NCI NIH HHS · R01 CA118165-04 · United States
NCI NIH HHS · R01 CA127923 · United States
External Links
PubMed source DOI: 10.1016/j.cell.2010.01.025 PMC Full Text View journal details
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