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PMID: 2549410 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Effect of combinations of antioxidants on phagocyte-induced sister-chromatid exchanges.

Mutation research ·Vol. 224 ·No. 1 ·1989-09-00 ·Pages 1-4

Weitberg AB

Abstract

Combinations of oxygen radical scavengers and antioxidants significantly reduced the number of sister-chromatid exchanges in Chinese hamster ovary cells exposed to human phagocytes stimulated to generate oxygen radicals. When vitamin E was combined with these antioxidants, no increase in sister-chromatid exchanges was observed compared to controls.

MeSH Terms

Animals Antioxidants/pharmacology Catalase/metabolism Cell Line Cricetinae Cricetulus Cytochrome c Group/analysis Free Radicals Humans Oxygen/metabolism Phagocytes/metabolism Sister Chromatid Exchange/drug effects Superoxide Dismutase/metabolism Tetradecanoylphorbol Acetate/toxicity Vitamin E/pharmacology

Chemicals

Antioxidants Cytochrome c Group Free Radicals Vitamin E Catalase Superoxide Dismutase Tetradecanoylphorbol Acetate Oxygen

Authors & Affiliations

1 authors, click to expand affiliations / ORCID

Weitberg A B

Division of Hematology/Oncology, Roger Williams Cancer Center, Providence, RI 02908.

Article Info

Journal

Mutation research

Abbr.

Mutat Res

ISSN

0027-5107

DOI

10.1016/0165-1218(89)90002-5

Published

1989-09-00

Pages

1-4

Language

English

Region

Netherlands

NLM ID

0400763

Subset

Grants

NCI NIH HHS · CA-00962 · United States

External Links

PubMed source DOI: 10.1016/0165-1218(89)90002-5 View journal details

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Effect of combinations of antioxidants on phagocyte-induced sister-chromatid exchanges.

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