Home LiteratureArticle Details
PMID: 18978338 Published · ppublish English Journal Article Research Support, N.I.H., Intramural Review

Base excision repair of oxidative DNA damage and association with cancer and aging.

Carcinogenesis ·Vol. 30 ·No. 1 ·2009-01-00 ·Pages 2-10

Maynard S, Schurman SH, Harboe C, de Souza-Pinto NC, Bohr VA

Abstract

Aging has been associated with damage accumulation in the genome and with increased cancer incidence. Reactive oxygen species (ROS) are produced from endogenous sources, most notably the oxidative metabolism in the mitochondria, and from exogenous sources, such as ionizing radiation. ROS attack DNA readily, generating a variety of DNA lesions, such as oxidized bases and strand breaks. If not properly removed, DNA damage can be potentially devastating to normal cell physiology, leading to mutagenesis and/or cell death, especially in the case of cytotoxic lesions that block the progression of DNA/RNA polymerases. Damage-induced mutagenesis has been linked to various malignancies. The major mechanism that cells use to repair oxidative damage lesions, such as 8-hydroxyguanine, formamidopyrimidines, and 5-hydroxyuracil, is base excision repair (BER). The BER pathway in the nucleus is well elucidated. More recently, BER was shown to also exist in the mitochondria. Here, we review the association of BER of oxidative DNA damage with aging, cancer and other diseases.

MeSH Terms
Aging/genetics Animals Base Pairing DNA Damage DNA Repair Humans Neoplasms/genetics Oxidative Stress Reactive Oxygen Species/metabolism Subcellular Fractions/metabolism
Chemicals
Reactive Oxygen Species
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Maynard Scott
Laboratory of Molecular Gerontology, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA.
Schurman Shepherd H
Harboe Charlotte
de Souza-Pinto Nadja C
Bohr Vilhelm A
References (185)
185 references, click to expand
  1. Mitochondrial DNA damage is more extensive and persists longer than nuclear DNA damage in human cells following oxidative stress.
    Proc Natl Acad Sci U S A. 1997 Jan 21;94(2):514-9 PMID: 9012815
  2. Nuclear and mitochondrial uracil-DNA glycosylases are generated by alternative splicing and transcription from different positions in the UNG gene.
    Nucleic Acids Res. 1997 Feb 15;25(4):750-5 PMID: 9016624
  3. Mitochondrial DNA mutations, oxidative stress, and apoptosis in mammalian aging.
    Science. 2005 Jul 15;309(5733):481-4 PMID: 16020738
  4. XRCC1 polymorphisms and cancer risk: a meta-analysis of 38 case-control studies.
    Cancer Epidemiol Biomarkers Prev. 2005 Jul;14(7):1810-8 PMID: 16030121
  5. Nuclear and mitochondrial DNA repair: similar pathways?
    Mitochondrion. 2005 Apr;5(2):89-108 PMID: 16050976
  6. NEIL1 excises 3' end proximal oxidative DNA lesions resistant to cleavage by NTH1 and OGG1.
    Nucleic Acids Res. 2005;33(15):4849-56 PMID: 16129732
  7. Genome-wide responses to DNA-damaging agents.
    Annu Rev Microbiol. 2005;59:357-77 PMID: 16153173
  8. Genetic polymorphisms in the base excision repair pathway and cancer risk: a HuGE review.
    Am J Epidemiol. 2005 Nov 15;162(10):925-42 PMID: 16221808
  9. Molecular and biological roles of Ape1 protein in mammalian base excision repair.
    DNA Repair (Amst). 2005 Dec 8;4(12):1442-9 PMID: 16199212
  10. Base-excision repair of oxidative DNA damage by DNA glycosylases.
    Mutat Res. 2005 Dec 11;591(1-2):45-59 PMID: 16054172
  11. Mechanisms of eukaryotic DNA double strand break repair.
    Front Biosci. 2006;11:1958-76 PMID: 16368571
  12. Genomic instability and aging-like phenotype in the absence of mammalian SIRT6.
    Cell. 2006 Jan 27;124(2):315-29 PMID: 16439206
  13. DNA polymerase gamma in mitochondrial DNA replication and repair.
    Chem Rev. 2006 Feb;106(2):383-405 PMID: 16464011
  14. The metabolic syndrome resulting from a knockout of the NEIL1 DNA glycosylase.
    Proc Natl Acad Sci U S A. 2006 Feb 7;103(6):1864-9 PMID: 16446448
  15. Genetic polymorphisms in base-excision repair pathway genes and risk of breast cancer.
    Cancer Epidemiol Biomarkers Prev. 2006 Feb;15(2):353-8 PMID: 16492928
  16. Genotype profiles of loci encoding DNA repair enzymes in newborn and elderly populations: no evidence of association with longevity.
    Biogerontology. 2006 Feb;7(1):35-41 PMID: 16518718
  17. Evidence for attenuated cellular 8-oxo-7,8-dihydro-2'-deoxyguanosine removal in cancer patients.
    Biol Chem. 2006 Apr;387(4):393-400 PMID: 16606337
  18. Mechanisms of formation, genotoxicity, and mutation of guanine oxidation products.
    Chem Res Toxicol. 2006 Apr;19(4):491-505 PMID: 16608160
  19. Identification and characterization of mitochondrial abasic (AP)-endonuclease in mammalian cells.
    Nucleic Acids Res. 2006;34(7):2067-76 PMID: 16617147
  20. Mitochondrial metabolic states regulate nitric oxide and hydrogen peroxide diffusion to the cytosol.
    Biochim Biophys Acta. 2006 May-Jun;1757(5-6):535-42 PMID: 16615992
  21. A concise review of DNA damage checkpoints and repair in mammalian cells.
    Cardiovasc Revasc Med. 2006 Jul-Sep;7(3):165-72 PMID: 16945824
  22. Mechanisms in eukaryotic mismatch repair.
    J Biol Chem. 2006 Oct 13;281(41):30305-9 PMID: 16905530
  23. Nucleotide excision repair and cancer.
    J Mol Histol. 2006 Sep;37(5-7):225-38 PMID: 16855787
  24. Association of genetic polymorphisms in the base excision repair pathway with lung cancer risk: a meta-analysis.
    Lung Cancer. 2006 Dec;54(3):267-83 PMID: 16982113
  25. DNA repair in neurons: so if they don't divide what's to repair?
    Mutat Res. 2007 Jan 3;614(1-2):24-36 PMID: 16879837
  26. An integrated view of oxidative stress in aging: basic mechanisms, functional effects, and pathological considerations.
    Am J Physiol Regul Integr Comp Physiol. 2007 Jan;292(1):R18-36 PMID: 16917020
  27. The role of oxidative stress in the pathogenesis of Alzheimer's disease.
    Bratisl Lek Listy. 2006;107(9-10):384-94 PMID: 17262991
  28. Reactive oxygen species and antioxidant mechanisms in human tissues and their relation to malignancies.
    APMIS. 2007 Feb;115(2):81-103 PMID: 17295675
  29. Mitochondria and human cancer.
    Curr Mol Med. 2007 Feb;7(1):121-31 PMID: 17311537
  30. Repair of alkylated DNA: recent advances.
    DNA Repair (Amst). 2007 Apr 1;6(4):429-42 PMID: 17112791
  31. The mechanics of base excision repair, and its relationship to aging and disease.
    DNA Repair (Amst). 2007 Apr 1;6(4):544-59 PMID: 17112792
  32. Mammalian single-strand break repair: mechanisms and links with chromatin.
    DNA Repair (Amst). 2007 Apr 1;6(4):443-53 PMID: 17118715
  33. Oxidative modification of proteins: age-related changes.
    Gerontology. 2007;53(3):128-39 PMID: 17164550
  34. Base excision repair and the central nervous system.
    Neuroscience. 2007 Apr 14;145(4):1187-200 PMID: 16934943
  35. DNA repair pathways and hereditary cancer susceptibility syndromes.
    Front Biosci. 2007;12:4191-207 PMID: 17485367
  36. DNA double-strand break repair: from mechanistic understanding to cancer treatment.
    DNA Repair (Amst). 2007 Jul 1;6(7):923-35 PMID: 17363343
  37. Defective DNA base excision repair in brain from individuals with Alzheimer's disease and amnestic mild cognitive impairment.
    Nucleic Acids Res. 2007;35(16):5545-55 PMID: 17704129
  38. Declining cellular fitness with age promotes cancer initiation by selecting for adaptive oncogenic mutations.
    Biochim Biophys Acta. 2008 Jan;1785(1):1-11 PMID: 17980163
  39. Two distinct pathways of cell death triggered by oxidative damage to nuclear and mitochondrial DNAs.
    EMBO J. 2008 Jan 23;27(2):421-32 PMID: 18188152
  40. DNA damage and repair: from molecular mechanisms to health implications.
    Antioxid Redox Signal. 2008 May;10(5):891-937 PMID: 18205545
  41. Mitochondrial base excision repair of uracil and AP sites takes place by single-nucleotide insertion and long-patch DNA synthesis.
    DNA Repair (Amst). 2008 Apr 2;7(4):605-16 PMID: 18295553
  42. ROS-generating mitochondrial DNA mutations can regulate tumor cell metastasis.
    Science. 2008 May 2;320(5876):661-4 PMID: 18388260
  43. Cytotoxicity and mutagenicity of endogenous DNA base lesions as potential cause of human aging.
    Mech Ageing Dev. 2008 Jul-Aug;129(7-8):353-65 PMID: 18355895
  44. Removal of oxidative DNA damage via FEN1-dependent long-patch base excision repair in human cell mitochondria.
    Mol Cell Biol. 2008 Aug;28(16):4975-87 PMID: 18541666
  45. Long patch base excision repair in mammalian mitochondrial genomes.
    J Biol Chem. 2008 Sep 26;283(39):26349-56 PMID: 18635552
  46. Mitochondrial targeting of human DNA glycosylases for repair of oxidative DNA damage.
    Nucleic Acids Res. 1998 Jun 15;26(12):2917-22 PMID: 9611236
  47. Oxidative damage to proteins, lipids, and DNA in cortical brain regions from patients with dementia with Lewy bodies.
    J Neurochem. 1998 Jul;71(1):302-12 PMID: 9648879
  48. DNA mismatch repair: molecular mechanisms and biological function.
    Annu Rev Microbiol. 2003;57:579-608 PMID: 14527292
  49. [Study of 8-OH-dG and its correlation with several cancer related gene in lung cancer tissues].
    Wei Sheng Yan Jiu. 2003 Jul;32(4):304-7 PMID: 14535088
  50. Mitochondrial formation of reactive oxygen species.
    J Physiol. 2003 Oct 15;552(Pt 2):335-44 PMID: 14561818
  51. The eukaryotic nucleotide excision repair pathway.
    Biochimie. 2003 Nov;85(11):1083-99 PMID: 14726015
  52. The role of oxidative stress in carcinogenesis.
    Annu Rev Pharmacol Toxicol. 2004;44:239-67 PMID: 14744246
  53. Retinoids and TRAIL: two cooperating actors to fight against cancer.
    Vitam Horm. 2004;67:319-45 PMID: 15110184
  54. Deficiencies in mouse Myh and Ogg1 result in tumor predisposition and G to T mutations in codon 12 of the K-ras oncogene in lung tumors.
    Cancer Res. 2004 May 1;64(9):3096-102 PMID: 15126346
  55. Apoptosis as a novel target for cancer chemoprevention.
    J Natl Cancer Inst. 2004 May 5;96(9):662-72 PMID: 15126603
  56. Stable down-regulation of human polynucleotide kinase enhances spontaneous mutation frequency and sensitizes cells to genotoxic agents.
    Proc Natl Acad Sci U S A. 2004 May 4;101(18):6905-10 PMID: 15100409
  57. The absence of a pyrimidine dimer repair mechanism in mammalian mitochondria.
    Proc Natl Acad Sci U S A. 1974 Jul;71(7):2777-81 PMID: 4212385
  58. Hydroperoxide metabolism in mammalian organs.
    Physiol Rev. 1979 Jul;59(3):527-605 PMID: 37532
  59. Mitochondrial DNA sequences of primates: tempo and mode of evolution.
    J Mol Evol. 1982;18(4):225-39 PMID: 6284948
  60. Roles of lipid turnover in transmembrane signal transduction.
    Am J Med Sci. 1991 Nov;302(5):304-12 PMID: 1661067
  61. Mutations in the DNA ligase I gene of an individual with immunodeficiencies and cellular hypersensitivity to DNA-damaging agents.
    Cell. 1992 May 1;69(3):495-503 PMID: 1581963
  62. Negative regulation of catalase gene expression in hepatoma cells.
    Mol Cell Biol. 1992 Jun;12(6):2525-33 PMID: 1588955
  63. Growth retardation and immunodeficiency in a patient with mutations in the DNA ligase I gene.
    Lancet. 1992 Jun 20;339(8808):1508-9 PMID: 1351188
  64. Reactive oxygen species and the central nervous system.
    J Neurochem. 1992 Nov;59(5):1609-23 PMID: 1402908
  65. Repair of mitochondrial DNA after various types of DNA damage in Chinese hamster ovary cells.
    Carcinogenesis. 1992 Nov;13(11):1967-73 PMID: 1423864
  66. DNA repair and Alzheimer's disease.
    J Gerontol. 1992 Nov;47(6):B177-84 PMID: 1430845
  67. Free radical theory of aging: history.
    EXS. 1992;62:1-10 PMID: 1450577
  68. Modification of DNA bases in chromatin of intact target human cells by activated human polymorphonuclear leukocytes.
    Cancer Res. 1993 Mar 15;53(6):1269-72 PMID: 8383005
  69. Instability and decay of the primary structure of DNA.
    Nature. 1993 Apr 22;362(6422):709-15 PMID: 8469282
  70. Mitochondrial DNA deletions in human brain: regional variability and increase with advanced age.
    Nat Genet. 1992 Dec;2(4):324-9 PMID: 1303288
  71. The reaction of no with superoxide.
    Free Radic Res Commun. 1993;18(4):195-9 PMID: 8396550
  72. Mutagenesis by 8-oxoguanine: an enemy within.
    Trends Genet. 1993 Jul;9(7):246-9 PMID: 8379000
  73. Oxidative damage to mitochondrial DNA shows marked age-dependent increases in human brain.
    Ann Neurol. 1993 Oct;34(4):609-16 PMID: 8215249
  74. DNA base damage generated in vivo in hepatic chromatin of mice upon whole body gamma-irradiation.
    Int J Radiat Biol. 1993 Dec;64(6):645-50 PMID: 7903331
  75. Regulation of biosynthesis of nitric oxide.
    J Biol Chem. 1994 May 13;269(19):13725-8 PMID: 7514592
  76. Formation of 8-hydroxy-2'-deoxyguanosine and 4-hydroxy-2-nonenal-modified proteins in human renal-cell carcinoma.
    Int J Cancer. 1994 Sep 15;58(6):825-9 PMID: 7523311
  77. Persistent oxidative stress in cancer.
    FEBS Lett. 1995 Jan 16;358(1):1-3 PMID: 7821417
  78. The base excision repair pathway.
    Trends Biochem Sci. 1995 Oct;20(10):391-7 PMID: 8533150
  79. Dilated cardiomyopathy and neonatal lethality in mutant mice lacking manganese superoxide dismutase.
    Nat Genet. 1995 Dec;11(4):376-81 PMID: 7493016
  80. High levels of mitochondrial DNA deletions in skeletal muscle of old rhesus monkeys.
    Mech Ageing Dev. 1995 Sep 7;83(2):91-101 PMID: 8569289
  81. Requirement of mammalian DNA polymerase-beta in base-excision repair.
    Nature. 1996 Jan 11;379(6561):183-6 PMID: 8538772
  82. Mammalian base excision repair and DNA polymerase beta.
    Mutat Res. 1998 Jun;407(3):203-15 PMID: 9653447
  83. Genetic polymorphisms and alternative splicing of the hOGG1 gene, that is involved in the repair of 8-hydroxyguanine in damaged DNA.
    Oncogene. 1998 Jun 25;16(25):3219-25 PMID: 9681819
  84. Identification of 5'-deoxyribose phosphate lyase activity in human DNA polymerase gamma and its role in mitochondrial base excision repair in vitro.
    Proc Natl Acad Sci U S A. 1998 Oct 13;95(21):12244-8 PMID: 9770471
  85. Somatic mutations of the mitochondrial genome in human colorectal tumours.
    Nat Genet. 1998 Nov;20(3):291-3 PMID: 9806551
  86. Peroxynitrite-induced alterations in synaptosomal membrane proteins: insight into oxidative stress in Alzheimer's disease.
    J Neurochem. 1999 Jan;72(1):310-7 PMID: 9886083
  87. Down-regulation of human FEN-1 gene expression during differentiation of promyelocytic leukemia cells.
    Exp Mol Med. 1998 Dec 31;30(4):252-6 PMID: 9894157
  88. Oxidative alterations in Alzheimer's disease.
    Brain Pathol. 1999 Jan;9(1):133-46 PMID: 9989456
  89. Requirement for the Xrcc1 DNA base excision repair gene during early mouse development.
    Dev Biol. 1999 Apr 15;208(2):513-29 PMID: 10191063
  90. Mitochondrial DNA 4977 bp deletion and OH8dG levels correlate in the brain of aged subjects but not Alzheimer's disease patients.
    FASEB J. 1999 Jun;13(9):1083-8 PMID: 10336891
  91. DNA repair mechanisms for the recognition and removal of damaged DNA bases.
    Annu Rev Biophys Biomol Struct. 1999;28:101-28 PMID: 10410797
  92. Poly(ADP-ribosyl)ation reactions in the regulation of nuclear functions.
    Biochem J. 1999 Sep 1;342 ( Pt 2):249-68 PMID: 10455009
  93. Splicing DNA-damage responses to tumour cell death.
    Biochim Biophys Acta. 2004 Dec 10;1705(1):3-15 PMID: 15585169
  94. Messenger RNA turnover in eukaryotes: pathways and enzymes.
    Crit Rev Biochem Mol Biol. 2004 Jul-Aug;39(4):197-216 PMID: 15596551
  95. Chemical biology of nitric oxide: regulation and protective and toxic mechanisms.
    Curr Top Cell Regul. 1996;34:159-87 PMID: 8646847
  96. Role of oxygen free radicals in cancer development.
    Eur J Cancer. 1996 Jan;32A(1):30-8 PMID: 8695238
  97. Prevention of mammary tumorigenesis in acatalasemic mice by vitamin E supplementation.
    Jpn J Cancer Res. 1996 Jul;87(7):680-4 PMID: 8698615
  98. DNA ligase I is required for fetal liver erythropoiesis but is not essential for mammalian cell viability.
    Nat Genet. 1996 Aug;13(4):489-91 PMID: 8696349
  99. Potassium deprivation-induced apoptosis of cerebellar granule neurons: a sequential requirement for new mRNA and protein synthesis, ICE-like protease activity, and reactive oxygen species.
    J Neurosci. 1996 Aug 1;16(15):4696-706 PMID: 8764657
  100. The redox/DNA repair protein, Ref-1, is essential for early embryonic development in mice.
    Proc Natl Acad Sci U S A. 1996 Aug 20;93(17):8919-23 PMID: 8799128
  101. Gene-specific nuclear and mitochondrial repair of formamidopyrimidine DNA glycosylase-sensitive sites in Chinese hamster ovary cells.
    Mutat Res. 1996 Dec 2;364(3):183-92 PMID: 8960130
  102. Mechanisms of anti-cancer agents: emphasis on oxidative stress and electron transfer.
    Curr Pharm Des. 2000 Feb;6(3):277-309 PMID: 10637380
  103. Identification of human MutY homolog (hMYH) as a repair enzyme for 2-hydroxyadenine in DNA and detection of multiple forms of hMYH located in nuclei and mitochondria.
    Nucleic Acids Res. 2000 Mar 15;28(6):1355-64 PMID: 10684930
  104. Nucleotide excision repair and human syndromes.
    Carcinogenesis. 2000 Mar;21(3):453-60 PMID: 10688865
  105. Facile detection of mitochondrial DNA mutations in tumors and bodily fluids.
    Science. 2000 Mar 17;287(5460):2017-9 PMID: 10720328
  106. Initiation of base excision repair: glycosylase mechanisms and structures.
    Annu Rev Biochem. 1999;68:255-85 PMID: 10872450
  107. The frequency of point mutations in mitochondrial DNA is elevated in the Alzheimer's brain.
    Biochem Biophys Res Commun. 2000 Jun 24;273(1):203-8 PMID: 10873587
  108. Linking DNA damage and neurodegeneration.
    Trends Neurosci. 2000 Sep;23(9):417-24 PMID: 10941191
  109. Oxidative damage to mitochondrial DNA and activity of mitochondrial enzymes in chronic active lesions of multiple sclerosis.
    J Neurol Sci. 2000 Aug 15;177(2):95-103 PMID: 10980305
  110. Deficient DNA end joining activity in extracts from fanconi anemia fibroblasts.
    J Biol Chem. 2001 Mar 23;276(12):9543-9 PMID: 11124945
  111. Oxidative DNA base damage and its repair in kidneys and livers of nickel(II)-treated male F344 rats.
    Carcinogenesis. 1997 Feb;18(2):271-7 PMID: 9054618
  112. Dependence of H2O2 formation by rat heart mitochondria on substrate availability and donor age.
    J Bioenerg Biomembr. 1997 Feb;29(1):89-95 PMID: 9067806
  113. Oxidative stress: oxidants and antioxidants.
    Exp Physiol. 1997 Mar;82(2):291-5 PMID: 9129943
  114. Evidence of reduced DNA repair in amyotrophic lateral sclerosis brain tissue.
    Neuroreport. 1997 Apr 14;8(6):1337-40 PMID: 9172131
  115. DNA glycosylases in the base excision repair of DNA.
    Biochem J. 1997 Jul 1;325 ( Pt 1):1-16 PMID: 9224623
  116. Interaction of human apurinic endonuclease and DNA polymerase beta in the base excision repair pathway.
    Proc Natl Acad Sci U S A. 1997 Jul 8;94(14):7166-9 PMID: 9207062
  117. Mitochondrial DNA maintenance in vertebrates.
    Annu Rev Biochem. 1997;66:409-35 PMID: 9242913
  118. Repair of oxidative damage to nuclear and mitochondrial DNA in mammalian cells.
    J Biol Chem. 1997 Oct 10;272(41):25409-12 PMID: 9325246
  119. Cisplatin is a DNA-damaging antitumour compound triggering multifactorial biochemical responses in cancer cells: importance of apoptotic pathways.
    Curr Med Chem Anticancer Agents. 2005 May;5(3):251-65 PMID: 15992353
  120. Localization of mitochondrial DNA base excision repair to an inner membrane-associated particulate fraction.
    Nucleic Acids Res. 2005;33(12):3722-32 PMID: 16006620
  121. Repair of alkali-labile sites within the mitochondrial DNA of RINr 38 cells after exposure to the nitrosourea streptozotocin.
    J Biol Chem. 1991 Feb 15;266(5):3113-7 PMID: 1825207
  122. Nitric oxide: physiology, pathophysiology, and pharmacology.
    Pharmacol Rev. 1991 Jun;43(2):109-42 PMID: 1852778
  123. Chemical determination of free radical-induced damage to DNA.
    Free Radic Biol Med. 1991;10(3-4):225-42 PMID: 1650738
  124. Efficient repair of abasic sites in DNA by mitochondrial enzymes.
    Mol Cell Biol. 1998 Mar;18(3):1257-65 PMID: 9488440
  125. Mutant AP endonuclease in patients with amyotrophic lateral sclerosis.
    Neuroreport. 1998 Jan 26;9(2):239-42 PMID: 9507962
  126. Oxidative stress and antioxidants in intestinal disease.
    Dig Dis. 1998 May-Jun;16(3):152-8 PMID: 9618134
  127. CuZnSOD deficiency leads to persistent and widespread oxidative damage and hepatocarcinogenesis later in life.
    Oncogene. 2005 Jan 13;24(3):367-80 PMID: 15531919
  128. The intracellular localization of APE1/Ref-1: more than a passive phenomenon?
    Antioxid Redox Signal. 2005 Mar-Apr;7(3-4):367-84 PMID: 15706084
  129. Interindividual variability in response to sodium dichromate-induced oxidative DNA damage: role of the Ser326Cys polymorphism in the DNA-repair protein of 8-oxo-7,8-dihydro-2'-deoxyguanosine DNA glycosylase 1.
    Cancer Epidemiol Biomarkers Prev. 2005 Feb;14(2):497-505 PMID: 15734978
  130. Mitochondria, oxidants, and aging.
    Cell. 2005 Feb 25;120(4):483-95 PMID: 15734681
  131. DNA repair, genome stability, and aging.
    Cell. 2005 Feb 25;120(4):497-512 PMID: 15734682
  132. Protein-protein interactions and posttranslational modifications in mammalian base excision repair.
    Free Radic Biol Med. 2005 May 1;38(9):1121-38 PMID: 15808410
  133. Expression of 8-oxoguanine DNA glycosylase (OGG1) in Parkinson's disease and related neurodegenerative disorders.
    Acta Neuropathol. 2005 Mar;109(3):256-62 PMID: 15841414
  134. XRCC1 is required for DNA single-strand break repair in human cells.
    Nucleic Acids Res. 2005;33(8):2512-20 PMID: 15867196
  135. DNA mismatch repair.
    Annu Rev Biochem. 2005;74:681-710 PMID: 15952900
  136. Cellular responses to DNA damage.
    Annu Rev Pharmacol Toxicol. 2001;41:367-401 PMID: 11264462
  137. Genome maintenance mechanisms for preventing cancer.
    Nature. 2001 May 17;411(6835):366-74 PMID: 11357144
  138. XRCC1, XRCC3, XPD gene polymorphisms, smoking and (32)P-DNA adducts in a sample of healthy subjects.
    Carcinogenesis. 2001 Sep;22(9):1437-45 PMID: 11532866
  139. Oxidative stress induces neuronal death by recruiting a protease and phosphatase-gated mechanism.
    J Biol Chem. 2001 Sep 14;276(37):35049-59 PMID: 11443132
  140. Regulation of intracellular localization of human MTH1, OGG1, and MYH proteins for repair of oxidative DNA damage.
    Prog Nucleic Acid Res Mol Biol. 2001;68:75-94 PMID: 11554314
  141. Completion of base excision repair by mammalian DNA ligases.
    Prog Nucleic Acid Res Mol Biol. 2001;68:151-64 PMID: 11554294
  142. Multiple DNA glycosylases for repair of 8-oxoguanine and their potential in vivo functions.
    Prog Nucleic Acid Res Mol Biol. 2001;68:193-205 PMID: 11554297
  143. The major human abasic endonuclease: formation, consequences and repair of abasic lesions in DNA.
    Mutat Res. 2001 May 10;485(4):283-307 PMID: 11585362
  144. Hypoxia and oxidative stress in breast cancer. Oxidative stress: its effects on the growth, metastatic potential and response to therapy of breast cancer.
    Breast Cancer Res. 2001;3(5):323-7 PMID: 11597322
  145. Inherited variants of MYH associated with somatic G:C-->T:A mutations in colorectal tumors.
    Nat Genet. 2002 Feb;30(2):227-32 PMID: 11818965
  146. Defective repair of 8-hydroxyguanine in mitochondria of MCF-7 and MDA-MB-468 human breast cancer cell lines.
    Cancer Res. 2002 Mar 1;62(5):1349-55 PMID: 11888904
  147. Toxic metals and oxidative stress part I: mechanisms involved in metal-induced oxidative damage.
    Curr Top Med Chem. 2001 Dec;1(6):529-39 PMID: 11895129
  148. Repair of oxidative DNA damage in nuclear and mitochondrial DNA, and some changes with aging in mammalian cells.
    Free Radic Biol Med. 2002 May 1;32(9):804-12 PMID: 11978482
  149. Protein turnover by the proteasome in aging and disease.
    Free Radic Biol Med. 2002 Jun 1;32(11):1084-9 PMID: 12031893
  150. Free radical-induced damage to DNA: mechanisms and measurement.
    Free Radic Biol Med. 2002 Jun 1;32(11):1102-15 PMID: 12031895
  151. DNA base-excision repair enzyme apurinic/apyrimidinic endonuclease/redox factor-1 is increased and competent in the brain and spinal cord of individuals with amyotrophic lateral sclerosis.
    Neuromolecular Med. 2002;2(1):47-60 PMID: 12230304
  152. Human DNA glycosylases of the bacterial Fpg/MutM superfamily: an alternative pathway for the repair of 8-oxoguanine and other oxidation products in DNA.
    Nucleic Acids Res. 2002 Nov 15;30(22):4926-36 PMID: 12433996
  153. Uracil in DNA--occurrence, consequences and repair.
    Oncogene. 2002 Dec 16;21(58):8935-48 PMID: 12483510
  154. Progress in the analysis of urinary oxidative DNA damage.
    Free Radic Biol Med. 2002 Dec 15;33(12):1601-14 PMID: 12488129
  155. Expression of antioxidant enzymes in diseases of the human pancreas: another link between chronic pancreatitis and pancreatic cancer.
    Pancreas. 2003 Jan;26(1):23-7 PMID: 12499913
  156. Accumulation of point mutations in mitochondrial DNA of aging mice.
    Mutat Res. 2003 May 15;526(1-2):1-7 PMID: 12714177
  157. DNA polymerase gamma in mitochondrial DNA replication and repair.
    ScientificWorldJournal. 2003 Mar 17;3:34-44 PMID: 12806118
  158. Oxidative DNA damage: mechanisms, mutation, and disease.
    FASEB J. 2003 Jul;17(10):1195-214 PMID: 12832285
  159. Proliferation failure and gamma radiation sensitivity of Fen1 null mutant mice at the blastocyst stage.
    Mol Cell Biol. 2003 Aug;23(15):5346-53 PMID: 12861020
  160. Base excision repair activities required for yeast to attain a full chronological life span.
    Aging Cell. 2003 Apr;2(2):93-104 PMID: 12882322
  161. From genotype to phenotype: correlating XRCC1 polymorphisms with mutagen sensitivity.
    DNA Repair (Amst). 2003 Aug 12;2(8):901-8 PMID: 12893086
  162. Gene-targeted mice lacking the Ung uracil-DNA glycosylase develop B-cell lymphomas.
    Oncogene. 2003 Aug 21;22(35):5381-6 PMID: 12934097
  163. Oxidants, antioxidants and carcinogenesis.
    Indian J Exp Biol. 2002 Nov;40(11):1213-32 PMID: 13677623
  164. Human uracil-DNA glycosylase deficiency associated with profoundly impaired immunoglobulin class-switch recombination.
    Nat Immunol. 2003 Oct;4(10):1023-8 PMID: 12958596
  165. Base excision repair deficiency caused by polymerase beta haploinsufficiency: accelerated DNA damage and increased mutational response to carcinogens.
    Cancer Res. 2003 Sep 15;63(18):5799-807 PMID: 14522902
  166. Oxidative damage is increased in human liver tissue adjacent to hepatocellular carcinoma.
    Hepatology. 2004 Jun;39(6):1663-72 PMID: 15185308
  167. Molecular mechanisms of mammalian DNA repair and the DNA damage checkpoints.
    Annu Rev Biochem. 2004;73:39-85 PMID: 15189136
  168. DNA polymerase gamma, the mitochondrial replicase.
    Annu Rev Biochem. 2004;73:293-320 PMID: 15189144
  169. AP endonuclease-independent DNA base excision repair in human cells.
    Mol Cell. 2004 Jul 23;15(2):209-20 PMID: 15260972
  170. Cellular repair of oxidatively induced DNA base lesions is defective in prostate cancer cell lines, PC-3 and DU-145.
    Carcinogenesis. 2004 Aug;25(8):1359-70 PMID: 15044326
  171. Oxidative DNA damage and disease: induction, repair and significance.
    Mutat Res. 2004 Sep;567(1):1-61 PMID: 15341901
  172. Neurodegenerative diseases: a decade of discoveries paves the way for therapeutic breakthroughs.
    Nat Med. 2004 Oct;10(10):1055-63 PMID: 15459709
  173. Is there a link between DNA polymerase beta and cancer?
    Cell Cycle. 2004 Aug;3(8):998-1001 PMID: 15280658
  174. The C-terminal alphaO helix of human Ogg1 is essential for 8-oxoguanine DNA glycosylase activity: the mitochondrial beta-Ogg1 lacks this domain and does not have glycosylase activity.
    Nucleic Acids Res. 2004;32(18):5596-608 PMID: 15494448
  175. Rate of depurination of native deoxyribonucleic acid.
    Biochemistry. 1972 Sep 12;11(19):3610-8 PMID: 4626532
  176. Novel effects of nitric oxide.
    Annu Rev Pharmacol Toxicol. 2001;41:203-36 PMID: 11264456
  177. Active oxygen acts as a promoter of transformation in mouse embryo C3H/10T1/2/C18 fibroblasts.
    Proc Natl Acad Sci U S A. 1984 Apr;81(7):2085-7 PMID: 6425826
  178. Apurinic sites as mutagenic intermediates.
    Cell. 1985 Mar;40(3):483-4 PMID: 2982494
  179. Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor.
    Nature. 1987 Jun 11-17;327(6122):524-6 PMID: 3495737
  180. Sequence analysis of cDNAs for the human and bovine ATP synthase beta subunit: mitochondrial DNA genes sustain seventeen times more mutations.
    Curr Genet. 1987;12(2):81-90 PMID: 2896550
  181. Free radicals in aging.
    Mol Cell Biochem. 1988 Dec;84(2):155-61 PMID: 3068521
  182. Repair of intrinsic DNA lesions.
    Mutat Res. 1990 May;238(3):305-11 PMID: 1692969
  183. Free radicals, antioxidant enzymes, and carcinogenesis.
    Free Radic Biol Med. 1990;8(6):583-99 PMID: 2193855
  184. Oxidants stress induces the proto-oncogenes, C-fos and C-myc in mouse epidermal cells.
    Bull Cancer. 1990;77(5):501-2 PMID: 2400824
  185. Production of large amounts of hydrogen peroxide by human tumor cells.
    Cancer Res. 1991 Feb 1;51(3):794-8 PMID: 1846317
Article Info
Journal
Carcinogenesis
Abbr.
Carcinogenesis
ISSN
1460-2180
DOI
10.1093/carcin/bgn250
Published
2009-01-00
Epub
2008-00-31
Pages
2-10
Language
English
Region
England
NLM ID
8008055
PMCID
PMC2639036
Subset
IM
Grants
Intramural NIH HHS · United States
External Links
PubMed source DOI: 10.1093/carcin/bgn250 PMC Full Text View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: product@genelibs.com

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2