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PMID: 20192751 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Review

Guard cell signal transduction network: advances in understanding abscisic acid, CO2, and Ca2+ signaling.

Annual review of plant biology ·Vol. 61 ·2010-00-00 ·Pages 561-91

Kim TH, Böhmer M, Hu H, Nishimura N, Schroeder JI

Abstract

Stomatal pores are formed by pairs of specialized epidermal guard cells and serve as major gateways for both CO(2) influx into plants from the atmosphere and transpirational water loss of plants. Because they regulate stomatal pore apertures via integration of both endogenous hormonal stimuli and environmental signals, guard cells have been highly developed as a model system to dissect the dynamics and mechanisms of plant-cell signaling. The stress hormone ABA and elevated levels of CO(2) activate complex signaling pathways in guard cells that are mediated by kinases/phosphatases, secondary messengers, and ion channel regulation. Recent research in guard cells has led to a new hypothesis for how plants achieve specificity in intracellular calcium signaling: CO(2) and ABA enhance (prime) the calcium sensitivity of downstream calcium-signaling mechanisms. Recent progress in identification of early stomatal signaling components are reviewed here, including ABA receptors and CO(2)-binding response proteins, as well as systems approaches that advance our understanding of guard cell-signaling mechanisms.

MeSH Terms
Abscisic Acid/metabolism Calcium/metabolism Calcium Signaling Carbon Dioxide/metabolism Plant Stomata/cytology,metabolism Plants/metabolism Signal Transduction
Chemicals
Carbon Dioxide Abscisic Acid Calcium
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Kim Tae-Houn
University of California, San Diego, Division of Biological Sciences, La Jolla, California 92093-0116, USA. thkim@ucsd.edu
Böhmer Maik
Hu Honghong
Nishimura Noriyuki
Schroeder Julian I
References (204)
204 references, click to expand
  1. Convergence of calcium signaling pathways of pathogenic elicitors and abscisic acid in Arabidopsis guard cells.
    Plant Physiol. 2002 Dec;130(4):2152-63 PMID: 12481099
  2. Type 2C protein phosphatases directly regulate abscisic acid-activated protein kinases in Arabidopsis.
    Proc Natl Acad Sci U S A. 2009 Oct 13;106(41):17588-93 PMID: 19805022
  3. Protein phosphorylation activates the guard cell Ca2+ channel and is a prerequisite for gating by abscisic acid.
    Plant J. 2002 Oct;32(2):185-94 PMID: 12383084
  4. Abscisic acid inhibits type 2C protein phosphatases via the PYR/PYL family of START proteins.
    Science. 2009 May 22;324(5930):1068-71 PMID: 19407142
  5. The Arabidopsis NFYA5 transcription factor is regulated transcriptionally and posttranscriptionally to promote drought resistance.
    Plant Cell. 2008 Aug;20(8):2238-51 PMID: 18682547
  6. Guard-cell signalling for hydrogen peroxide and abscisic acid.
    New Phytol. 2008;178(4):703-718 PMID: 18373649
  7. AREB1 is a transcription activator of novel ABRE-dependent ABA signaling that enhances drought stress tolerance in Arabidopsis.
    Plant Cell. 2005 Dec;17(12):3470-88 PMID: 16284313
  8. Two calcium-dependent protein kinases, CPK4 and CPK11, regulate abscisic acid signal transduction in Arabidopsis.
    Plant Cell. 2007 Oct;19(10):3019-36 PMID: 17921317
  9. Abscisic acid activation of plasma membrane Ca(2+) channels in guard cells requires cytosolic NAD(P)H and is differentially disrupted upstream and downstream of reactive oxygen species production in abi1-1 and abi2-1 protein phosphatase 2C mutants.
    Plant Cell. 2001 Nov;13(11):2513-23 PMID: 11701885
  10. Cytosolic abscisic acid activates guard cell anion channels without preceding Ca2+ signals.
    Proc Natl Acad Sci U S A. 2005 Mar 15;102(11):4203-8 PMID: 15753314
  11. Arabidopsis transcriptome analysis under drought, cold, high-salinity and ABA treatment conditions using a tiling array.
    Plant Cell Physiol. 2008 Aug;49(8):1135-49 PMID: 18625610
  12. Functional proteomics of Arabidopsis thaliana guard cells uncovers new stomatal signaling pathways.
    Plant Cell. 2008 Dec;20(12):3210-26 PMID: 19114538
  13. Regulation of abscisic acid-induced stomatal closure and anion channels by guard cell AAPK kinase.
    Science. 2000 Jan 14;287(5451):300-3 PMID: 10634783
  14. Roles of ion channels and transporters in guard cell signal transduction.
    FEBS Lett. 2007 May 25;581(12):2325-36 PMID: 17462636
  15. The role of the mesophyll in stomatal responses to light and CO2.
    Plant Cell Environ. 2008 Sep;31(9):1299-306 PMID: 18541006
  16. Stress-induced changes in the Arabidopsis thaliana transcriptome analyzed using whole-genome tiling arrays.
    Plant J. 2009 Jun;58(6):1068-82 PMID: 19222804
  17. The AIP2 E3 ligase acts as a novel negative regulator of ABA signaling by promoting ABI3 degradation.
    Genes Dev. 2005 Jul 1;19(13):1532-43 PMID: 15998807
  18. Perception and transduction of abscisic acid signals: keys to the function of the versatile plant hormone ABA.
    Trends Plant Sci. 2007 Aug;12(8):343-51 PMID: 17629540
  19. Nitric oxide and abscisic acid cross talk in guard cells.
    Plant Physiol. 2002 Mar;128(3):790-2 PMID: 11891235
  20. CBL1, a calcium sensor that differentially regulates salt, drought, and cold responses in Arabidopsis.
    Plant Cell. 2003 Aug;15(8):1833-45 PMID: 12897256
  21. Calcium-Activated K+ Channels and Calcium-Induced Calcium Release by Slow Vacuolar Ion Channels in Guard Cell Vacuoles Implicated in the Control of Stomatal Closure.
    Plant Cell. 1994 May;6(5):669-683 PMID: 12244253
  22. Ca2+ signalling in plants and green algae--changing channels.
    Trends Plant Sci. 2008 Sep;13(9):506-14 PMID: 18703378
  23. Long-distance signalling of abscisic acid (ABA): the factors regulating the intensity of the ABA signal.
    J Exp Bot. 2008;59(1):37-43 PMID: 17595196
  24. The slow and the quick anion conductance in whole guard cells: their voltage-dependent alternation, and the modulation of their activities by abscisic acid and CO2.
    Planta. 2003 Aug;217(4):639-50 PMID: 12712336
  25. Gain-of-function and loss-of-function phenotypes of the protein phosphatase 2C HAB1 reveal its role as a negative regulator of abscisic acid signalling.
    Plant J. 2004 Feb;37(3):354-69 PMID: 14731256
  26. In vitro reconstitution of an abscisic acid signalling pathway.
    Nature. 2009 Dec 3;462(7273):660-4 PMID: 19924127
  27. High humidity induces abscisic acid 8'-hydroxylase in stomata and vasculature to regulate local and systemic abscisic acid responses in Arabidopsis.
    Plant Physiol. 2009 Feb;149(2):825-34 PMID: 19036833
  28. The nitrate/proton antiporter AtCLCa mediates nitrate accumulation in plant vacuoles.
    Nature. 2006 Aug 24;442(7105):939-42 PMID: 16878138
  29. Signal transduction and ion channels in guard cells.
    Philos Trans R Soc Lond B Biol Sci. 1998 Sep 29;353(1374):1475-88 PMID: 9800209
  30. Plant nuclear factor Y (NF-Y) B subunits confer drought tolerance and lead to improved corn yields on water-limited acres.
    Proc Natl Acad Sci U S A. 2007 Oct 16;104(42):16450-5 PMID: 17923671
  31. Overexpression of AtMYB44 enhances stomatal closure to confer abiotic stress tolerance in transgenic Arabidopsis.
    Plant Physiol. 2008 Feb;146(2):623-35 PMID: 18162593
  32. Stomatal development.
    Annu Rev Plant Biol. 2007;58:163-81 PMID: 17201685
  33. The regulator of G-protein signaling proteins involved in sugar and abscisic acid signaling in Arabidopsis seed germination.
    Plant Physiol. 2006 Jan;140(1):302-10 PMID: 16361523
  34. Role of Calcium in Signal Transduction of Commelina Guard Cells.
    Plant Cell. 1991 Apr;3(4):333-344 PMID: 12324599
  35. Stomatal movements and ion fluxes within epidermis of Commelina communis L.
    Nature. 1974 Nov 8;252(5479):126-7 PMID: 4417954
  36. The taste of carbonation.
    Science. 2009 Oct 16;326(5951):443-5 PMID: 19833970
  37. Detection of near-atmospheric concentrations of CO2 by an olfactory subsystem in the mouse.
    Science. 2007 Aug 17;317(5840):953-7 PMID: 17702944
  38. Molecular characterization of the Arabidopsis 9-cis epoxycarotenoid dioxygenase gene family.
    Plant J. 2003 Jul;35(1):44-56 PMID: 12834401
  39. Activation of glucosidase via stress-induced polymerization rapidly increases active pools of abscisic acid.
    Cell. 2006 Sep 22;126(6):1109-20 PMID: 16990135
  40. Abscisic acid-dependent multisite phosphorylation regulates the activity of a transcription activator AREB1.
    Proc Natl Acad Sci U S A. 2006 Feb 7;103(6):1988-93 PMID: 16446457
  41. ABA induction of miR159 controls transcript levels of two MYB factors during Arabidopsis seed germination.
    Plant J. 2007 Feb;49(4):592-606 PMID: 17217461
  42. Phosphorylation of the Arabidopsis AtrbohF NADPH oxidase by OST1 protein kinase.
    FEBS Lett. 2009 Sep 17;583(18):2982-6 PMID: 19716822
  43. The plant multidrug resistance ABC transporter AtMRP5 is involved in guard cell hormonal signalling and water use.
    Plant J. 2003 Jan;33(1):119-29 PMID: 12943546
  44. K+ channel activity in plants: genes, regulations and functions.
    FEBS Lett. 2007 May 25;581(12):2357-66 PMID: 17418142
  45. Unitary exocytotic and endocytotic events in guard-cell protoplasts during osmotically driven volume changes.
    FEBS Lett. 1999 Nov 5;460(3):495-9 PMID: 10556524
  46. Alteration of anion channel kinetics in wild-type and abi1-1 transgenic Nicotiana benthamiana guard cells by abscisic acid.
    Plant J. 1997 Jul;12(1):203-13 PMID: 9263461
  47. A nuclear factor regulates abscisic acid responses in Arabidopsis.
    Plant Physiol. 2009 Nov;151(3):1433-45 PMID: 19759343
  48. A Ca(2)+ signaling pathway regulates a K(+) channel for low-K response in Arabidopsis.
    Proc Natl Acad Sci U S A. 2006 Aug 15;103(33):12625-30 PMID: 16895985
  49. Repetitive increases in cytosolic Ca2+ of guard cells by abscisic acid activation of nonselective Ca2+ permeable channels.
    Proc Natl Acad Sci U S A. 1990 Dec;87(23):9305-9 PMID: 2174559
  50. Two calcineurin B-like calcium sensors, interacting with protein kinase CIPK23, regulate leaf transpiration and root potassium uptake in Arabidopsis.
    Plant J. 2007 Oct;52(2):223-39 PMID: 17922773
  51. Voltage dependence of K channels in guard-cell protoplasts.
    Proc Natl Acad Sci U S A. 1987 Jun;84(12):4108-12 PMID: 16593851
  52. Transcriptional regulatory networks in cellular responses and tolerance to dehydration and cold stresses.
    Annu Rev Plant Biol. 2006;57:781-803 PMID: 16669782
  53. CDPKs CPK6 and CPK3 function in ABA regulation of guard cell S-type anion- and Ca(2+)-permeable channels and stomatal closure.
    PLoS Biol. 2006 Oct;4(10):e327 PMID: 17032064
  54. The Arabidopsis thaliana ABC transporter AtMRP5 controls root development and stomata movement.
    EMBO J. 2001 Apr 17;20(8):1875-87 PMID: 11296221
  55. Malate-induced feedback regulation of plasma membrane anion channels could provide a CO2 sensor to guard cells.
    EMBO J. 1993 Mar;12(3):897-901 PMID: 7681395
  56. Differential abscisic acid regulation of guard cell slow anion channels in Arabidopsis wild-type and abi1 and abi2 mutants.
    Plant Cell. 1997 Mar;9(3):409-23 PMID: 9090884
  57. Involvement of Arabidopsis HOS15 in histone deacetylation and cold tolerance.
    Proc Natl Acad Sci U S A. 2008 Mar 25;105(12):4945-50 PMID: 18356294
  58. Nitric oxide regulates K+ and Cl- channels in guard cells through a subset of abscisic acid-evoked signaling pathways.
    Proc Natl Acad Sci U S A. 2003 Sep 16;100(19):11116-21 PMID: 12949257
  59. The Arabidopsis outward K+ channel GORK is involved in regulation of stomatal movements and plant transpiration.
    Proc Natl Acad Sci U S A. 2003 Apr 29;100(9):5549-54 PMID: 12671068
  60. G-protein complex mutants are hypersensitive to abscisic acid regulation of germination and postgermination development.
    Plant Physiol. 2006 May;141(1):243-56 PMID: 16581874
  61. CO2 regulator SLAC1 and its homologues are essential for anion homeostasis in plant cells.
    Nature. 2008 Mar 27;452(7186):483-6 PMID: 18305482
  62. Long-distance CO(2) signalling in plants.
    J Exp Bot. 2002 Feb;53(367):183-93 PMID: 11807121
  63. HAB1-SWI3B interaction reveals a link between abscisic acid signaling and putative SWI/SNF chromatin-remodeling complexes in Arabidopsis.
    Plant Cell. 2008 Nov;20(11):2972-88 PMID: 19033529
  64. Abscisic acid induces oscillations in guard-cell cytosolic free calcium that involve phosphoinositide-specific phospholipase C.
    Proc Natl Acad Sci U S A. 1999 Feb 16;96(4):1779-84 PMID: 9990101
  65. Epigenetic regulation of stress responses in plants.
    Curr Opin Plant Biol. 2009 Apr;12(2):133-9 PMID: 19179104
  66. TPK1 is a vacuolar ion channel different from the slow-vacuolar cation channel.
    Plant Physiol. 2005 Sep;139(1):417-24 PMID: 16113216
  67. Modulation of abscisic acid signal transduction and biosynthesis by an Sm-like protein in Arabidopsis.
    Dev Cell. 2001 Dec;1(6):771-81 PMID: 11740939
  68. Dependence of the Extent and Direction of Average Stomatal Response in Zea mays L. and Phaseolus vulgaris L. on the Frequency of Fluctuations in Environmental Stimuli.
    Plant Physiol. 1994 Jul;105(3):1007-1013 PMID: 12232261
  69. Calcium channels activated by hydrogen peroxide mediate abscisic acid signalling in guard cells.
    Nature. 2000 Aug 17;406(6797):731-4 PMID: 10963598
  70. Genetic characterization reveals no role for the reported ABA receptor, GCR2, in ABA control of seed germination and early seedling development in Arabidopsis.
    Plant J. 2007 Dec;52(6):1001-13 PMID: 17894782
  71. The chloroplast as a regulator of Ca2+ signalling.
    New Phytol. 2008;179(3):568-570 PMID: 18715320
  72. The coronatine-insensitive 1 mutation reveals the hormonal signaling interaction between abscisic acid and methyl jasmonate in Arabidopsis guard cells. Specific impairment of ion channel activation and second messenger production.
    Plant Physiol. 2007 Mar;143(3):1398-407 PMID: 17220365
  73. Cytoplasmic alkalization precedes reactive oxygen species production during methyl jasmonate- and abscisic acid-induced stomatal closure.
    Plant Physiol. 2004 Apr;134(4):1536-45 PMID: 15064385
  74. Hypersensitivity of abscisic acid-induced cytosolic calcium increases in the Arabidopsis farnesyltransferase mutant era1-2.
    Plant Cell. 2002 Jul;14(7):1649-62 PMID: 12119381
  75. Guard cell ABA and CO2 signaling network updates and Ca2+ sensor priming hypothesis.
    Curr Opin Plant Biol. 2006 Dec;9(6):654-63 PMID: 17010657
  76. Chromatin immunoprecipitation (ChIP) on chip experiments uncover a widespread distribution of NF-Y binding CCAAT sites outside of core promoters.
    J Biol Chem. 2005 Apr 8;280(14):13606-15 PMID: 15647281
  77. Disruption of AtMRP4, a guard cell plasma membrane ABCC-type ABC transporter, leads to deregulation of stomatal opening and increased drought susceptibility.
    Plant J. 2004 Jul;39(2):219-36 PMID: 15225287
  78. Calcium signaling through protein kinases. The Arabidopsis calcium-dependent protein kinase gene family.
    Plant Physiol. 2002 Jun;129(2):469-85 PMID: 12068094
  79. Monitoring the expression pattern of around 7,000 Arabidopsis genes under ABA treatments using a full-length cDNA microarray.
    Funct Integr Genomics. 2002 Nov;2(6):282-91 PMID: 12444421
  80. CIPK3, a calcium sensor-associated protein kinase that regulates abscisic acid and cold signal transduction in Arabidopsis.
    Plant Cell. 2003 Feb;15(2):411-23 PMID: 12566581
  81. The ATP binding cassette transporter AtMRP5 modulates anion and calcium channel activities in Arabidopsis guard cells.
    J Biol Chem. 2007 Jan 19;282(3):1916-24 PMID: 17098742
  82. GUARD CELL SIGNAL TRANSDUCTION.
    Annu Rev Plant Physiol Plant Mol Biol. 2001 Jun;52:627-658 PMID: 11337411
  83. A cell surface receptor mediates extracellular Ca(2+) sensing in guard cells.
    Nature. 2003 Sep 11;425(6954):196-200 PMID: 12968184
  84. Three Arabidopsis SnRK2 protein kinases, SRK2D/SnRK2.2, SRK2E/SnRK2.6/OST1 and SRK2I/SnRK2.3, involved in ABA signaling are essential for the control of seed development and dormancy.
    Plant Cell Physiol. 2009 Jul;50(7):1345-63 PMID: 19541597
  85. SDIR1 is a RING finger E3 ligase that positively regulates stress-responsive abscisic acid signaling in Arabidopsis.
    Plant Cell. 2007 Jun;19(6):1912-29 PMID: 17573536
  86. An mRNA cap binding protein, ABH1, modulates early abscisic acid signal transduction in Arabidopsis.
    Cell. 2001 Aug 24;106(4):477-87 PMID: 11525733
  87. The magnesium-chelatase H subunit binds abscisic acid and functions in abscisic acid signaling: new evidence in Arabidopsis.
    Plant Physiol. 2009 Aug;150(4):1940-54 PMID: 19535472
  88. Structural basis of abscisic acid signalling.
    Nature. 2009 Dec 3;462(7273):609-14 PMID: 19855379
  89. Membrane transport in stomatal guard cells: the importance of voltage control.
    J Membr Biol. 1992 Feb;126(1):1-18 PMID: 1534380
  90. Calcium Effects on Stomatal Movement in Commelina communis L. : Use of EGTA to Modulate Stomatal Response to Light, KCl and CO(2).
    Plant Physiol. 1988 Jul;87(3):583-7 PMID: 16666189
  91. Analysis of the Arabidopsis histidine kinase ATHK1 reveals a connection between vegetative osmotic stress sensing and seed maturation.
    Plant Cell. 2008 Apr;20(4):1101-17 PMID: 18441212
  92. The guard cell as a single-cell model towards understanding drought tolerance and abscisic acid action.
    J Exp Bot. 2009;60(5):1439-63 PMID: 19181866
  93. Constitutive activation of a plasma membrane H(+)-ATPase prevents abscisic acid-mediated stomatal closure.
    EMBO J. 2007 Jul 11;26(13):3216-26 PMID: 17557075
  94. Hormone interactions in stomatal function.
    Plant Mol Biol. 2009 Mar;69(4):451-62 PMID: 19031047
  95. Arabidopsis mutant deficient in 3 abscisic acid-activated protein kinases reveals critical roles in growth, reproduction, and stress.
    Proc Natl Acad Sci U S A. 2009 May 19;106(20):8380-5 PMID: 19420218
  96. Cytosolic Concentration of Ca2+ Regulates the Plasma Membrane H+-ATPase in Guard Cells of Fava Bean.
    Plant Cell. 1995 Aug;7(8):1333-1342 PMID: 12242406
  97. Drought induction of Arabidopsis 9-cis-epoxycarotenoid dioxygenase occurs in vascular parenchyma cells.
    Plant Physiol. 2008 Aug;147(4):1984-93 PMID: 18550687
  98. Selective mobility and sensitivity to SNAREs is exhibited by the Arabidopsis KAT1 K+ channel at the plasma membrane.
    Plant Cell. 2006 Apr;18(4):935-54 PMID: 16531497
  99. De-regulated expression of the plant glutamate receptor homolog AtGLR3.1 impairs long-term Ca2+-programmed stomatal closure.
    Plant J. 2009 May;58(3):437-49 PMID: 19143998
  100. Metabolomic and proteomic changes in the xylem sap of maize under drought.
    Plant Cell Environ. 2008 Mar;31(3):325-40 PMID: 18088330
  101. CO2 provides an intermediate link in the red light response of guard cells.
    Plant J. 2002 Oct;32(1):65-75 PMID: 12366801
  102. Historical warnings of future food insecurity with unprecedented seasonal heat.
    Science. 2009 Jan 9;323(5911):240-4 PMID: 19131626
  103. Two types of anion channel currents in guard cells with distinct voltage regulation.
    Proc Natl Acad Sci U S A. 1992 Jun 1;89(11):5025-9 PMID: 1375754
  104. A defined range of guard cell calcium oscillation parameters encodes stomatal movements.
    Nature. 2001 Jun 28;411(6841):1053-7 PMID: 11429606
  105. Modulation of drought resistance by the abscisic acid receptor PYL5 through inhibition of clade A PP2Cs.
    Plant J. 2009 Nov;60(4):575-88 PMID: 19624469
  106. CO(2)-triggered chloride release from guard cells in intact fava bean leaves. Kinetics of the onset of stomatal closure.
    Plant Physiol. 2002 Oct;130(2):940-50 PMID: 12376658
  107. Arabidopsis abi1-1 and abi2-1 phosphatase mutations reduce abscisic acid-induced cytoplasmic calcium rises in guard cells.
    Plant Cell. 1999 Sep;11(9):1785-98 PMID: 10488243
  108. Myrosinases, TGG1 and TGG2, redundantly function in ABA and MeJA signaling in Arabidopsis guard cells.
    Plant Cell Physiol. 2009 Jun;50(6):1171-5 PMID: 19433491
  109. Microarray expression analyses of Arabidopsis guard cells and isolation of a recessive abscisic acid hypersensitive protein phosphatase 2C mutant.
    Plant Cell. 2004 Mar;16(3):596-615 PMID: 14973164
  110. Carbonic anhydrases are upstream regulators of CO2-controlled stomatal movements in guard cells.
    Nat Cell Biol. 2010 Jan;12(1):87-93; sup pp 1-18 PMID: 20010812
  111. The multifaceted role of ABA in disease resistance.
    Trends Plant Sci. 2009 Jun;14(6):310-7 PMID: 19443266
  112. A novel chloride channel in Vicia faba guard cell vacuoles activated by the serine/threonine kinase, CDPK.
    EMBO J. 1996 Dec 2;15(23):6564-74 PMID: 8978683
  113. Identification of a novel E3 ubiquitin ligase that is required for suppression of premature senescence in Arabidopsis.
    Plant J. 2009 Jul;59(1):39-51 PMID: 19309463
  114. Signalling of abscisic acid to regulate plant growth.
    Philos Trans R Soc Lond B Biol Sci. 1998 Sep 29;353(1374):1439-44 PMID: 9800207
  115. Ca2+ channels at the plasma membrane of stomatal guard cells are activated by hyperpolarization and abscisic acid.
    Proc Natl Acad Sci U S A. 2000 Apr 25;97(9):4967-72 PMID: 10781106
  116. Characterization of the ABA-regulated global responses to dehydration in Arabidopsis by metabolomics.
    Plant J. 2009 Mar;57(6):1065-78 PMID: 19036030
  117. Structural mechanism of abscisic acid binding and signaling by dimeric PYR1.
    Science. 2009 Dec 4;326(5958):1373-9 PMID: 19933100
  118. Light regulation of stomatal movement.
    Annu Rev Plant Biol. 2007;58:219-47 PMID: 17209798
  119. KEEP ON GOING, a RING E3 ligase essential for Arabidopsis growth and development, is involved in abscisic acid signaling.
    Plant Cell. 2006 Dec;18(12):3415-28 PMID: 17194765
  120. A gate-latch-lock mechanism for hormone signalling by abscisic acid receptors.
    Nature. 2009 Dec 3;462(7273):602-8 PMID: 19898420
  121. G protein regulation of ion channels and abscisic acid signaling in Arabidopsis guard cells.
    Science. 2001 Jun 15;292(5524):2070-2 PMID: 11408655
  122. Nitric oxide, stomatal closure, and abiotic stress.
    J Exp Bot. 2008;59(2):165-76 PMID: 18332225
  123. The generation of Ca(2+) signals in plants.
    Annu Rev Plant Biol. 2004;55:401-27 PMID: 15377226
  124. Arabidopsis HT1 kinase controls stomatal movements in response to CO2.
    Nat Cell Biol. 2006 Apr;8(4):391-7 PMID: 16518390
  125. Hydrogen peroxide is a regulator of ABI1, a protein phosphatase 2C from Arabidopsis.
    FEBS Lett. 2001 Nov 23;508(3):443-6 PMID: 11728469
  126. Breaking the silence: three bHLH proteins direct cell-fate decisions during stomatal development.
    Bioessays. 2007 Sep;29(9):861-70 PMID: 17691100
  127. Ca2+ and nucleotide dependent regulation of voltage dependent anion channels in the plasma membrane of guard cells.
    EMBO J. 1990 Dec;9(12):3889-92 PMID: 1701140
  128. The role of calcium in ABA-induced gene expression and stomatal movements.
    Plant J. 2001 May;26(3):351-62 PMID: 11439123
  129. Role of stomata in plant innate immunity and foliar bacterial diseases.
    Annu Rev Phytopathol. 2008;46:101-22 PMID: 18422426
  130. Calcium elevation-dependent and attenuated resting calcium-dependent abscisic acid induction of stomatal closure and abscisic acid-induced enhancement of calcium sensitivities of S-type anion and inward-rectifying K channels in Arabidopsis guard cells.
    Plant J. 2009 Jul;59(2):207-20 PMID: 19302418
  131. Function of Nicotiana tabacum aquaporins as chloroplast gas pores challenges the concept of membrane CO2 permeability.
    Plant Cell. 2008 Mar;20(3):648-57 PMID: 18349152
  132. Activity of guard cell anion channel SLAC1 is controlled by drought-stress signaling kinase-phosphatase pair.
    Proc Natl Acad Sci U S A. 2009 Dec 15;106(50):21425-30 PMID: 19955405
  133. Calcineurin-B-like protein CBL9 interacts with target kinase CIPK3 in the regulation of ABA response in seed germination.
    Mol Plant. 2008 Mar;1(2):238-48 PMID: 19825536
  134. A plastid protein crucial for Ca2+-regulated stomatal responses.
    New Phytol. 2008;179(3):675-686 PMID: 18507772
  135. Vacuolar malate uptake is mediated by an anion-selective inward rectifier.
    Plant J. 2003 Jul;35(1):116-28 PMID: 12834407
  136. Plant hormones are versatile chemical regulators of plant growth.
    Nat Chem Biol. 2009 May;5(5):301-7 PMID: 19377456
  137. The calcium sensor calcineurin B-like 9 modulates abscisic acid sensitivity and biosynthesis in Arabidopsis.
    Plant Cell. 2004 Jul;16(7):1912-24 PMID: 15208400
  138. Tobacco aquaporin NtAQP1 is involved in mesophyll conductance to CO2 in vivo.
    Plant J. 2006 Nov;48(3):427-39 PMID: 17010114
  139. An Arabidopsis glutathione peroxidase functions as both a redox transducer and a scavenger in abscisic acid and drought stress responses.
    Plant Cell. 2006 Oct;18(10):2749-66 PMID: 16998070
  140. Reevaluation of abscisic acid-binding assays shows that G-Protein-Coupled Receptor2 does not bind abscisic Acid.
    Plant Physiol. 2009 May;150(1):6-11 PMID: 19286934
  141. Dominant negative guard cell K+ channel mutants reduce inward-rectifying K+ currents and light-induced stomatal opening in arabidopsis.
    Plant Physiol. 2001 Oct;127(2):473-85 PMID: 11598222
  142. PYR/PYL/RCAR family members are major in-vivo ABI1 protein phosphatase 2C-interacting proteins in Arabidopsis.
    Plant J. 2010 Jan;61(2):290-9 PMID: 19874541
  143. SLAC1 is required for plant guard cell S-type anion channel function in stomatal signalling.
    Nature. 2008 Mar 27;452(7186):487-91 PMID: 18305484
  144. Structural insights into the mechanism of abscisic acid signaling by PYL proteins.
    Nat Struct Mol Biol. 2009 Dec;16(12):1230-6 PMID: 19893533
  145. Two Transduction Pathways Mediate Rapid Effects of Abscisic Acid in Commelina Guard Cells.
    Plant Cell. 1994 Sep;6(9):1319-1328 PMID: 12244274
  146. The number of K(+) channels in the plasma membrane of guard cell protoplasts changes in parallel with the surface area.
    Proc Natl Acad Sci U S A. 2002 Jul 23;99(15):10215-20 PMID: 12096192
  147. Regulators of PP2C phosphatase activity function as abscisic acid sensors.
    Science. 2009 May 22;324(5930):1064-8 PMID: 19407143
  148. The regulatory domain of SRK2E/OST1/SnRK2.6 interacts with ABI1 and integrates abscisic acid (ABA) and osmotic stress signals controlling stomatal closure in Arabidopsis.
    J Biol Chem. 2006 Feb 24;281(8):5310-8 PMID: 16365038
  149. Decoding Ca(2+) signals through plant protein kinases.
    Annu Rev Plant Biol. 2004;55:263-88 PMID: 15377221
  150. ABA-activated SnRK2 protein kinase is required for dehydration stress signaling in Arabidopsis.
    Plant Cell Physiol. 2002 Dec;43(12):1473-83 PMID: 12514244
  151. Two chemosensory receptors together mediate carbon dioxide detection in Drosophila.
    Nature. 2007 Jan 4;445(7123):86-90 PMID: 17167414
  152. Guard cells in albino leaf patches do not respond to photosynthetically active radiation, but are sensitive to blue light, CO2 and abscisic acid.
    Plant Cell Environ. 2006 Aug;29(8):1595-605 PMID: 16898020
  153. A hydraulic signal in root-to-shoot signalling of water shortage.
    Plant J. 2007 Oct;52(1):167-74 PMID: 17711416
  154. A hypermorphic mutation in the protein phosphatase 2C HAB1 strongly affects ABA signaling in Arabidopsis.
    FEBS Lett. 2006 Aug 21;580(19):4691-6 PMID: 16876791
  155. Changes in cytosolic pH and calcium of guard cells precede stomatal movements.
    Proc Natl Acad Sci U S A. 1992 Mar 1;89(5):1790-4 PMID: 11607281
  156. Phot1 and phot2 mediate blue light-induced transient increases in cytosolic Ca2+ differently in Arabidopsis leaves.
    Proc Natl Acad Sci U S A. 2003 Jul 8;100(14):8583-8 PMID: 12821778
  157. Predicting essential components of signal transduction networks: a dynamic model of guard cell abscisic acid signaling.
    PLoS Biol. 2006 Oct;4(10):e312 PMID: 16968132
  158. The tobacco aquaporin NtAQP1 is a membrane CO2 pore with physiological functions.
    Nature. 2003 Oct 16;425(6959):734-7 PMID: 14520414
  159. Plant adaptation to fluctuating environment and biomass production are strongly dependent on guard cell potassium channels.
    Proc Natl Acad Sci U S A. 2008 Apr 1;105(13):5271-6 PMID: 18367672
  160. Role of an Arabidopsis AP2/EREBP-type transcriptional repressor in abscisic acid and drought stress responses.
    Plant Cell. 2005 Aug;17(8):2384-96 PMID: 15994908
  161. The two-pore channel TPK1 gene encodes the vacuolar K+ conductance and plays a role in K+ homeostasis.
    Proc Natl Acad Sci U S A. 2007 Jun 19;104(25):10726-31 PMID: 17563365
  162. Abscisic acid regulation of guard-cell K+ and anion channels in Gbeta- and RGS-deficient Arabidopsis lines.
    Proc Natl Acad Sci U S A. 2008 Jun 17;105(24):8476-81 PMID: 18541915
  163. A G protein-coupled receptor is a plasma membrane receptor for the plant hormone abscisic acid.
    Science. 2007 Mar 23;315(5819):1712-6 PMID: 17347412
  164. The Arabidopsis vacuolar malate channel is a member of the ALMT family.
    Plant J. 2007 Dec;52(6):1169-80 PMID: 18005230
  165. Arabidopsis calcium-dependent protein kinase AtCPK32 interacts with ABF4, a transcriptional regulator of abscisic acid-responsive gene expression, and modulates its activity.
    Plant Physiol. 2005 Dec;139(4):1750-61 PMID: 16299177
  166. Guard cell metabolism and CO2 sensing.
    New Phytol. 2005 Mar;165(3):665-82 PMID: 15720679
  167. A slow anion channel in guard cells, activating at large hyperpolarization, may be principal for stomatal closing.
    FEBS Lett. 1992 Nov 16;313(1):27-30 PMID: 1385219
  168. The Arabidopsis cytochrome P450 CYP707A encodes ABA 8'-hydroxylases: key enzymes in ABA catabolism.
    EMBO J. 2004 Apr 7;23(7):1647-56 PMID: 15044947
  169. A protein kinase-phosphatase pair interacts with an ion channel to regulate ABA signaling in plant guard cells.
    Proc Natl Acad Sci U S A. 2009 Dec 15;106(50):21419-24 PMID: 19955427
  170. Upregulation of an Arabidopsis RING-H2 gene, XERICO, confers drought tolerance through increased abscisic acid biosynthesis.
    Plant J. 2006 Aug;47(3):343-55 PMID: 16792696
  171. Alternative complex formation of the Ca-regulated protein kinase CIPK1 controls abscisic acid-dependent and independent stress responses in Arabidopsis.
    Plant J. 2006 Dec;48(6):857-72 PMID: 17092313
  172. A protein kinase, interacting with two calcineurin B-like proteins, regulates K+ transporter AKT1 in Arabidopsis.
    Cell. 2006 Jun 30;125(7):1347-60 PMID: 16814720
  173. Triple loss of function of protein phosphatases type 2C leads to partial constitutive response to endogenous abscisic acid.
    Plant Physiol. 2009 Jul;150(3):1345-55 PMID: 19458118
  174. Protein phosphatases 2C regulate the activation of the Snf1-related kinase OST1 by abscisic acid in Arabidopsis.
    Plant Cell. 2009 Oct;21(10):3170-84 PMID: 19855047
  175. The ABC transporter AtABCB14 is a malate importer and modulates stomatal response to CO2.
    Nat Cell Biol. 2008 Oct;10(10):1217-23 PMID: 18776898
  176. Cameleon calcium indicator reports cytoplasmic calcium dynamics in Arabidopsis guard cells.
    Plant J. 1999 Sep;19(6):735-47 PMID: 10571859
  177. The barley magnesium chelatase 150-kd subunit is not an abscisic acid receptor.
    Plant Physiol. 2009 May;150(1):157-66 PMID: 19176716
  178. CO(2) signaling in guard cells: calcium sensitivity response modulation, a Ca(2+)-independent phase, and CO(2) insensitivity of the gca2 mutant.
    Proc Natl Acad Sci U S A. 2006 May 9;103(19):7506-11 PMID: 16651523
  179. Membrane voltage initiates Ca2+ waves and potentiates Ca2+ increases with abscisic acid in stomatal guard cells.
    Proc Natl Acad Sci U S A. 1998 Apr 14;95(8):4778-83 PMID: 9539815
  180. The abscisic acid receptor PYR1 in complex with abscisic acid.
    Nature. 2009 Dec 3;462(7273):665-8 PMID: 19898494
  181. Alternation of the slow with the quick anion conductance in whole guard cells effected by external malate.
    Planta. 2003 Aug;217(4):651-7 PMID: 12712337
  182. Arabidopsis OST1 protein kinase mediates the regulation of stomatal aperture by abscisic acid and acts upstream of reactive oxygen species production.
    Plant Cell. 2002 Dec;14(12):3089-99 PMID: 12468729
  183. ABA-induced NO generation and stomatal closure in Arabidopsis are dependent on H2O2 synthesis.
    Plant J. 2006 Jan;45(1):113-22 PMID: 16367958
  184. Water-stress-induced changes in the abscisic acid content of guard cells and other cells of Vicia faba L. leaves as determined by enzyme-amplified immunoassay.
    Proc Natl Acad Sci U S A. 1988 Apr;85(8):2584-8 PMID: 16593922
  185. The HIC signalling pathway links CO2 perception to stomatal development.
    Nature. 2000 Dec 7;408(6813):713-6 PMID: 11130071
  186. The ubiquitin-26S proteasome system at the nexus of plant biology.
    Nat Rev Mol Cell Biol. 2009 Jun;10(6):385-97 PMID: 19424292
  187. Sumoylation of ABI5 by the Arabidopsis SUMO E3 ligase SIZ1 negatively regulates abscisic acid signaling.
    Proc Natl Acad Sci U S A. 2009 Mar 31;106(13):5418-23 PMID: 19276109
  188. Strong regulation of slow anion channels and abscisic acid signaling in guard cells by phosphorylation and dephosphorylation events.
    Proc Natl Acad Sci U S A. 1995 Oct 10;92(21):9535-9 PMID: 11607582
  189. The protein phosphatase AtPP2CA negatively regulates abscisic acid signal transduction in Arabidopsis, and effects of abh1 on AtPP2CA mRNA.
    Plant Physiol. 2006 Jan;140(1):127-39 PMID: 16361522
  190. Isolation of a strong Arabidopsis guard cell promoter and its potential as a research tool.
    Plant Methods. 2008 Feb 19;4:6 PMID: 18284694
  191. Two novel GPCR-type G proteins are abscisic acid receptors in Arabidopsis.
    Cell. 2009 Jan 9;136(1):136-48 PMID: 19135895
  192. A guard-cell-specific MYB transcription factor regulates stomatal movements and plant drought tolerance.
    Curr Biol. 2005 Jul 12;15(13):1196-200 PMID: 16005291
  193. Use of the glucosyltransferase UGT71B6 to disturb abscisic acid homeostasis in Arabidopsis thaliana.
    Plant J. 2006 May;46(3):492-502 PMID: 16623908
  194. Abscisic acid biosynthesis and catabolism.
    Annu Rev Plant Biol. 2005;56:165-85 PMID: 15862093
  195. NADPH oxidase AtrbohD and AtrbohF genes function in ROS-dependent ABA signaling in Arabidopsis.
    EMBO J. 2003 Jun 2;22(11):2623-33 PMID: 12773379
  196. The calcium sensor CBL1 integrates plant responses to abiotic stresses.
    Plant J. 2003 Nov;36(4):457-70 PMID: 14617077
  197. MAP kinases MPK9 and MPK12 are preferentially expressed in guard cells and positively regulate ROS-mediated ABA signaling.
    Proc Natl Acad Sci U S A. 2009 Dec 1;106(48):20520-5 PMID: 19910530
  198. Changes in apoplastic pH and membrane potential in leaves in relation to stomatal responses to CO2, malate, abscisic acid or interruption of water supply.
    Planta. 2001 Aug;213(4):594-601 PMID: 11556792
  199. The Arabidopsis E3 SUMO ligase SIZ1 regulates plant growth and drought responses.
    Plant Cell. 2007 Sep;19(9):2952-66 PMID: 17905899
  200. Abscisic acid triggers the endocytosis of the arabidopsis KAT1 K+ channel and its recycling to the plasma membrane.
    Curr Biol. 2007 Aug 21;17(16):1396-402 PMID: 17683934
  201. Release of Malate from Epidermal Strips during Stomatal Closure.
    Plant Physiol. 1978 Mar;61(3):474-5 PMID: 16660318
  202. Role of calcium in the modulation of Vicia guard cell potassium channels by abscisic acid: a patch-clamp study.
    J Membr Biol. 1994 Jan;137(2):99-107 PMID: 8006956
  203. The Mg-chelatase H subunit is an abscisic acid receptor.
    Nature. 2006 Oct 19;443(7113):823-6 PMID: 17051210
  204. AtMYB61, an R2R3-MYB transcription factor controlling stomatal aperture in Arabidopsis thaliana.
    Curr Biol. 2005 Jul 12;15(13):1201-6 PMID: 16005292
Article Info
Journal
Annual review of plant biology
Abbr.
Annu Rev Plant Biol
ISSN
1545-2123
DOI
10.1146/annurev-arplant-042809-112226
Email
thkim@ucsd.edu
Published
2010-00-00
Pages
561-91
Language
English
Region
United States
NLM ID
101140127
PMCID
PMC3056615
Subset
IM
Grants
NIGMS NIH HHS · R01 GM060396 · United States
NIGMS NIH HHS · GM060396 · United States
NIEHS NIH HHS · P42 ES010337 · United States
NIGMS NIH HHS · R01 GM060396-10 · United States
NIEHS NIH HHS · ES010337 · United States
External Links
PubMed source DOI: 10.1146/annurev-arplant-042809-112226 PMC Full Text View journal details
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