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PMID: 20121095 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Natural products version 2.0: connecting genes to molecules.

Journal of the American Chemical Society ·Vol. 132 ·No. 8 ·2010-03-03 ·Pages 2469-93

Walsh CT, Fischbach MA

Abstract

Natural products have played a prominent role in the history of organic chemistry, and they continue to be important as drugs, biological probes, and targets of study for synthetic and analytical chemists. In this Perspective, we explore how connecting Nature's small molecules to the genes that encode them has sparked a renaissance in natural product research, focusing primarily on the biosynthesis of polyketides and non-ribosomal peptides. We survey monomer biogenesis, coupling chemistries from templated and non-templated pathways, and the broad set of tailoring reactions and hybrid pathways that give rise to the diverse scaffolds and functionalization patterns of natural products. We conclude by considering two questions: What would it take to find all natural product scaffolds? What kind of scientists will be studying natural products in the future?

MeSH Terms
Biological Products/genetics,metabolism Genes Genes, Bacterial Macrolides/chemistry,metabolism Peptide Biosynthesis Peptides/chemistry,genetics,metabolism
Chemicals
Biological Products Macrolides Peptides
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Walsh Christopher T
Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, 240 Longwood Avenue, Boston, Massachusetts 02115, USA. christopher_walsh@hms.harvard.edu
Fischbach Michael A
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Article Info
Journal
Journal of the American Chemical Society
Abbr.
J Am Chem Soc
ISSN
1520-5126
DOI
10.1021/ja909118a
Email
christopher_walsh@hms.harvard.edu
Published
2010-03-03
Pages
2469-93
Language
English
Region
United States
NLM ID
7503056
PMCID
PMC2828520
Subset
IM
Grants
NIGMS NIH HHS · F32 GM020011 · United States
NIGMS NIH HHS · R01 GM049338 · United States
NIGMS NIH HHS · GM49338 · United States
NIAID NIH HHS · U54 AI057159 · United States
NIAID NIH HHS · U54 AI057159-03 · United States
NIGMS NIH HHS · R01 GM049338-17 · United States
NIAID NIH HHS · AI42738 · United States
NIAID NIH HHS · R01 AI042738 · United States
NIAID NIH HHS · AI057159 · United States
NIGMS NIH HHS · R01 GM020011-39 · United States
NIGMS NIH HHS · GM20011 · United States
NIGMS NIH HHS · R01 GM049338-16 · United States
NIAID NIH HHS · R01 AI042738-12 · United States
NIGMS NIH HHS · R01 GM020011 · United States
External Links
PubMed source DOI: 10.1021/ja909118a PMC Full Text View journal details
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