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PMID: 12714063 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S. Review

Polyketide biosynthesis beyond the type I, II and III polyketide synthase paradigms.

Current opinion in chemical biology ·Vol. 7 ·No. 2 ·2003-04-00 ·Pages 285-95

Shen B

Abstract

Recent literature on polyketide biosynthesis suggests that polyketide synthases have much greater diversity in both mechanism and structure than the current type I, II and III paradigms. These examples serve as an inspiration for searching novel polyketide synthases to give new insights into polyketide biosynthesis and to provide new opportunities for combinatorial biosynthesis.

MeSH Terms

Biological Factors/chemical synthesis Combinatorial Chemistry Techniques Multienzyme Complexes/metabolism

Chemicals

Biological Factors Multienzyme Complexes

Authors & Affiliations

1 authors, click to expand affiliations / ORCID

Shen Ben

Division of Pharmaceutical Sciences and Department of Chemistry, University of Wisconsin, Madison, WI 53705, USA. bshen@pharmacy.wisc.edu

Article Info

Journal

Current opinion in chemical biology

Abbr.

Curr Opin Chem Biol

ISSN

1367-5931

DOI

10.1016/s1367-5931(03)00020-6

bshen@pharmacy.wisc.edu

Published

2003-04-00

Pages

285-95

Language

English

Region

England

NLM ID

9811312

Subset

Grants

NIAID NIH HHS · AI51689 · United States

NCI NIH HHS · CA78747 · United States

External Links

PubMed source DOI: 10.1016/s1367-5931(03)00020-6 View journal details

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Polyketide biosynthesis beyond the type I, II and III polyketide synthase paradigms.

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