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PMID: 15724180 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Equisetin biosynthesis in Fusarium heterosporum.

Chemical communications (Cambridge, England) ·No. 2 ·2005-01-14 ·Pages 186-8

Sims JW, Fillmore JP, Warner DD, Schmidt EW

Abstract

An iterative polyketide synthase-peptide synthetase hybrid assembles the HIV-1 integrase inhibitory tetramic acid, equisetin, in the filamentous fungus Fusarium heterosporum.

MeSH Terms
Fusarium/classification,genetics,metabolism Gene Deletion Genes, Fungal Molecular Structure Multigene Family Pyrrolidinones/chemistry,metabolism Tetrahydronaphthalenes/chemistry,metabolism
Chemicals
Pyrrolidinones Tetrahydronaphthalenes equisetin
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Sims James W
Department of Medicinal Chemistry, University of Utah, 30 South 2000 East Rm 201, Salt Lake City, UT 84112, USA.
Fillmore John P
Warner Douglas D
Schmidt Eric W
Article Info
Journal
Chemical communications (Cambridge, England)
Abbr.
Chem Commun (Camb)
ISSN
1359-7345
DOI
10.1039/b413523g
Published
2005-01-14
Epub
2004-00-22
Pages
186-8
Language
English
Region
England
NLM ID
9610838
Subset
IM
External Links
PubMed source DOI: 10.1039/b413523g View journal details
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