Home LiteratureArticle Details
PMID: 19251475 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Review

New developments in microbial interspecies signaling.

Current opinion in microbiology ·Vol. 12 ·No. 2 ·2009-04-00 ·Pages 205-14

Shank EA, Kolter R

Abstract

There is a growing appreciation that in addition to well-documented intraspecies quorum sensing systems, small molecules act as signals between microbes of different species. This review will focus on how bacterial small molecules modulate these interspecies interactions. We will particularly emphasize complex relationships such as those between microbes and insects, interactions resulting in non-antagonistic outcomes (i.e. developmental and morphological processes), how co-culture can lead to the discovery of new small molecules, and the use of known compounds to evoke unexpected responses and mediate crosstalk between microbes.

MeSH Terms
Animals Bacterial Physiological Phenomena Fungi/physiology Homoserine/analogs & derivatives,metabolism Host-Pathogen Interactions/physiology Insecta/physiology Lactones/metabolism Peptidoglycan/metabolism Quorum Sensing/physiology Signal Transduction/physiology Symbiosis/physiology
Chemicals
Lactones N-octanoylhomoserine lactone Peptidoglycan Homoserine
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Shank Elizabeth Anne
Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, MA 02115, USA. roberto_kolter@hms.harvard.edu
Kolter Roberto
References (62)
62 references, click to expand
  1. A singular enzymatic megacomplex from Bacillus subtilis.
    Proc Natl Acad Sci U S A. 2007 Jan 2;104(1):305-10 PMID: 17190806
  2. Feast or famine: the global regulator DasR links nutrient stress to antibiotic production by Streptomyces.
    EMBO Rep. 2008 Jul;9(7):670-5 PMID: 18511939
  3. Quorum sensing and virulence regulation in Xanthomonas campestris.
    FEMS Microbiol Rev. 2008 Aug;32(5):842-57 PMID: 18557946
  4. Role for glycine betaine transport in Vibrio cholerae osmoadaptation and biofilm formation within microbial communities.
    Appl Environ Microbiol. 2005 Jul;71(7):3840-7 PMID: 16000796
  5. A novel DSF-like signal from Burkholderia cenocepacia interferes with Candida albicans morphological transition.
    ISME J. 2008 Jan;2(1):27-36 PMID: 18049456
  6. Midgut bacteria required for Bacillus thuringiensis insecticidal activity.
    Proc Natl Acad Sci U S A. 2006 Oct 10;103(41):15196-9 PMID: 17005725
  7. Signal-mediated interactions between Pseudomonas aeruginosa and Candida albicans.
    J Med Microbiol. 2008 May;57(Pt 5):563-569 PMID: 18436588
  8. Mixed-species biofilm formation by lactic acid bacteria and rice wine yeasts.
    Appl Environ Microbiol. 2007 Jul;73(14):4673-6 PMID: 17526778
  9. A bacterial cell-cell communication signal with cross-kingdom structural analogues.
    Mol Microbiol. 2004 Feb;51(3):903-12 PMID: 14731288
  10. Antibiotics as intermicrobial signaling agents instead of weapons.
    Proc Natl Acad Sci U S A. 2006 Dec 19;103(51):19484-9 PMID: 17148599
  11. Subinhibitory concentrations of azithromycin decrease nontypeable Haemophilus influenzae biofilm formation and Diminish established biofilms.
    Antimicrob Agents Chemother. 2008 Jan;52(1):137-45 PMID: 17954687
  12. Effects of subinhibitory concentrations of antibiotics on SOS and DNA repair gene expression in Staphylococcus aureus.
    Antimicrob Agents Chemother. 2008 Sep;52(9):3394-7 PMID: 18591271
  13. A eukaryotic-like Ser/Thr kinase signals bacteria to exit dormancy in response to peptidoglycan fragments.
    Cell. 2008 Oct 31;135(3):486-96 PMID: 18984160
  14. Spatial and temporal population dynamics of a naturally occurring two-species microbial community inside the digestive tract of the medicinal leech.
    Appl Environ Microbiol. 2007 Mar;73(6):1984-91 PMID: 17277211
  15. Autoinducer 2: a concentration-dependent signal for mutualistic bacterial biofilm growth.
    Mol Microbiol. 2006 Jun;60(6):1446-56 PMID: 16796680
  16. Strategies to unravel the function of orphan biosynthesis pathways: recent examples and future prospects.
    Appl Microbiol Biotechnol. 2007 May;75(2):267-77 PMID: 17340107
  17. Antibiotics as signals that trigger specific bacterial responses.
    Curr Opin Microbiol. 2008 Apr;11(2):161-7 PMID: 18373943
  18. Isolating "uncultivable" microorganisms in pure culture in a simulated natural environment.
    Science. 2002 May 10;296(5570):1127-9 PMID: 12004133
  19. Living in two worlds: the plant and insect lifestyles of Xylella fastidiosa.
    Annu Rev Phytopathol. 2008;46:243-71 PMID: 18422428
  20. The identification of bacillaene, the product of the PksX megacomplex in Bacillus subtilis.
    Proc Natl Acad Sci U S A. 2007 Jan 30;104(5):1506-9 PMID: 17234808
  21. Volatile organic compounds: a potential direct long-distance mechanism for antagonistic action of Fusarium oxysporum strain MSA 35.
    Environ Microbiol. 2009 Apr;11(4):844-54 PMID: 19396945
  22. Breaching the great wall: peptidoglycan and microbial interactions.
    Nat Rev Microbiol. 2006 Sep;4(9):710-6 PMID: 16894338
  23. SO-LAAO, a novel L-amino acid oxidase that enables Streptococcus oligofermentans to outcompete Streptococcus mutans by generating H2O2 from peptone.
    J Bacteriol. 2008 Jul;190(13):4716-21 PMID: 18469105
  24. Competition and coexistence between Streptococcus mutans and Streptococcus sanguinis in the dental biofilm.
    J Bacteriol. 2005 Nov;187(21):7193-203 PMID: 16237003
  25. Diffusible signal factor-dependent cell-cell signaling and virulence in the nosocomial pathogen Stenotrophomonas maltophilia.
    J Bacteriol. 2007 Jul;189(13):4964-8 PMID: 17468254
  26. Quorum sensing: cell-to-cell communication in bacteria.
    Annu Rev Cell Dev Biol. 2005;21:319-46 PMID: 16212498
  27. Peptidoglycan from Bacillus cereus mediates commensalism with rhizosphere bacteria from the Cytophaga-Flavobacterium group.
    Appl Environ Microbiol. 2006 Aug;72(8):5421-7 PMID: 16885294
  28. Bacterial ectosymbionts and virulence silencing in a Fusarium oxysporum strain.
    Environ Microbiol. 2008 Jul;10(7):1725-41 PMID: 18397306
  29. Control of the transcription of a short gene encoding a cyclic peptide in Streptococcus thermophilus: a new quorum-sensing system?
    J Bacteriol. 2007 Dec;189(24):8844-54 PMID: 17921293
  30. Redox-active antibiotics control gene expression and community behavior in divergent bacteria.
    Science. 2008 Aug 29;321(5893):1203-6 PMID: 18755976
  31. Biofilm interactions between distinct bacterial genera isolated from drinking water.
    Appl Environ Microbiol. 2007 Oct;73(19):6192-200 PMID: 17675433
  32. Selection for Staphylococcus aureus small-colony variants due to growth in the presence of Pseudomonas aeruginosa.
    Proc Natl Acad Sci U S A. 2006 Dec 26;103(52):19890-5 PMID: 17172450
  33. Effects of antibiotics on quorum sensing in Pseudomonas aeruginosa.
    Antimicrob Agents Chemother. 2008 Oct;52(10):3648-63 PMID: 18644954
  34. Interspecies signalling via the Stenotrophomonas maltophilia diffusible signal factor influences biofilm formation and polymyxin tolerance in Pseudomonas aeruginosa.
    Mol Microbiol. 2008 Apr;68(1):75-86 PMID: 18312265
  35. Incubation of environmental samples in a diffusion chamber increases the diversity of recovered isolates.
    Appl Environ Microbiol. 2007 Oct;73(20):6386-90 PMID: 17720826
  36. Controlled synthesis of the DSF cell-cell signal is required for biofilm formation and virulence in Xanthomonas campestris.
    Environ Microbiol. 2007 Aug;9(8):2101-9 PMID: 17635553
  37. Libertellenones A-D: induction of cytotoxic diterpenoid biosynthesis by marine microbial competition.
    Bioorg Med Chem. 2005 Sep 1;13(17):5267-73 PMID: 15993608
  38. NspS, a predicted polyamine sensor, mediates activation of Vibrio cholerae biofilm formation by norspermidine.
    J Bacteriol. 2005 Nov;187(21):7434-43 PMID: 16237027
  39. A community of ants, fungi, and bacteria: a multilateral approach to studying symbiosis.
    Annu Rev Microbiol. 2001;55:357-80 PMID: 11544360
  40. Induced production of emericellamides A and B from the marine-derived fungus Emericella sp. in competing co-culture.
    J Nat Prod. 2007 Apr;70(4):515-20 PMID: 17323993
  41. Streptococcus oligofermentans inhibits Streptococcus mutans through conversion of lactic acid into inhibitory H2O2: a possible counteroffensive strategy for interspecies competition.
    Mol Microbiol. 2007 Feb;63(3):872-80 PMID: 17302806
  42. Short peptide induces an "uncultivable" microorganism to grow in vitro.
    Appl Environ Microbiol. 2008 Aug;74(15):4889-97 PMID: 18515474
  43. A fatty acid messenger is responsible for inducing dispersion in microbial biofilms.
    J Bacteriol. 2009 Mar;191(5):1393-403 PMID: 19074399
  44. Involvement of nitric oxide in biofilm dispersal of Pseudomonas aeruginosa.
    J Bacteriol. 2006 Nov;188(21):7344-53 PMID: 17050922
  45. A new class of homoserine lactone quorum-sensing signals.
    Nature. 2008 Jul 31;454(7204):595-9 PMID: 18563084
  46. Stimulation of Fusobacterium nucleatum biofilm formation by Porphyromonas gingivalis.
    Oral Microbiol Immunol. 2008 Feb;23(1):1-6 PMID: 18173791
  47. Mucin-Pseudomonas aeruginosa interactions promote biofilm formation and antibiotic resistance.
    Mol Microbiol. 2006 Jan;59(1):142-51 PMID: 16359324
  48. Diversification of the function of cell-to-cell signaling in regulation of virulence within plant pathogenic xanthomonads.
    Sci Signal. 2008 May 27;1(21):pe23 PMID: 18506032
  49. Interactions between Streptomyces coelicolor and Bacillus subtilis: Role of surfactants in raising aerial structures.
    J Bacteriol. 2006 Jul;188(13):4918-25 PMID: 16788200
  50. Induction of coordinated movement of Myxococcus xanthus cells.
    J Bacteriol. 1982 Oct;152(1):451-61 PMID: 6811560
  51. Farnesol, a common sesquiterpene, inhibits PQS production in Pseudomonas aeruginosa.
    Mol Microbiol. 2007 Aug;65(4):896-906 PMID: 17640272
  52. Diffusible signals and interspecies communication in bacteria.
    Microbiology (Reading). 2008 Jul;154(Pt 7):1845-1858 PMID: 18599814
  53. A linear pentapeptide is a quorum-sensing factor required for mazEF-mediated cell death in Escherichia coli.
    Science. 2007 Oct 26;318(5850):652-5 PMID: 17962566
  54. Talking to themselves: autoregulation and quorum sensing in fungi.
    Eukaryot Cell. 2006 Apr;5(4):613-9 PMID: 16607008
  55. Bacterial peptidoglycan triggers Candida albicans hyphal growth by directly activating the adenylyl cyclase Cyr1p.
    Cell Host Microbe. 2008 Jul 17;4(1):28-39 PMID: 18621008
  56. Feedback control of morphogenesis in fungi by aromatic alcohols.
    Genes Dev. 2006 May 1;20(9):1150-61 PMID: 16618799
  57. Bacterial protection of beetle-fungus mutualism.
    Science. 2008 Oct 3;322(5898):63 PMID: 18832638
  58. Biofilm dispersal in Xanthomonas campestris is controlled by cell-cell signaling and is required for full virulence to plants.
    Proc Natl Acad Sci U S A. 2003 Sep 16;100(19):10995-1000 PMID: 12960398
  59. Rippling is a predatory behavior in Myxococcus xanthus.
    J Bacteriol. 2006 Aug;188(16):5888-95 PMID: 16885457
  60. Rhodostreptomycins, antibiotics biosynthesized following horizontal gene transfer from Streptomyces padanus to Rhodococcus fascians.
    J Am Chem Soc. 2008 Jan 30;130(4):1126-7 PMID: 18179219
  61. Multicellular development in Myxococcus xanthus is stimulated by predator-prey interactions.
    J Bacteriol. 2007 Aug;189(15):5675-82 PMID: 17513469
  62. Ancient host-pathogen associations maintained by specificity of chemotaxis and antibiosis.
    PLoS Biol. 2006 Jul;4(8):e235 PMID: 16805647
Article Info
Journal
Current opinion in microbiology
Abbr.
Curr Opin Microbiol
ISSN
1879-0364
DOI
10.1016/j.mib.2009.01.003
Email
roberto_kolter@hms.harvard.edu
Published
2009-04-00
Epub
2009-00-27
Pages
205-14
Language
English
Region
England
NLM ID
9815056
PMCID
PMC2709175
Subset
IM
Grants
NIGMS NIH HHS · R01 GM082137 · United States
NIGMS NIH HHS · R01 GM082137-01 · United States
NIGMS NIH HHS · GM82137 · United States
External Links
PubMed source DOI: 10.1016/j.mib.2009.01.003 PMC Full Text View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: product@genelibs.com

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2