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PMID: 19680248 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

Bacterial cell division: assembly, maintenance and disassembly of the Z ring.

Nature reviews. Microbiology ·Vol. 7 ·No. 9 ·2009-09-00 ·Pages 642-53

Adams DW, Errington J

Abstract

Bacterial cell division is orchestrated by a tubulin homologue, FtsZ, which polymerizes to form a ring-like structure that is both a scaffold for the assembly of the bacterial cytokinetic machinery and, at least in part, a source of the energy for constriction. FtsZ assembly is tightly regulated, and a diverse repertoire of accessory proteins contributes to the formation of a functional division machine that is responsive to cell cycle status and environmental stress. In this Review, we describe the interaction of these proteins with FtsZ and discuss recent advances in our understanding of Z ring assembly.

MeSH Terms
Bacterial Physiological Phenomena Bacterial Proteins/metabolism Cell Division Cytoskeletal Proteins/metabolism Models, Biological Models, Molecular Protein Binding Protein Multimerization
Chemicals
Bacterial Proteins Cytoskeletal Proteins FtsZ protein, Bacteria
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Adams David W
Centre for Bacterial Cell Biology, Institute for Cell and Molecular Biosciences, Newcastle University, Medical School, Framlington Place, Newcastle-upon-Tyne, NE2 4HH, UK.
Errington Jeff
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Article Info
Journal
Nature reviews. Microbiology
Abbr.
Nat Rev Microbiol
ISSN
1740-1534
DOI
10.1038/nrmicro2198
Published
2009-09-00
Pages
642-53
Language
English
Region
England
NLM ID
101190261
Subset
IM
Grants
Biotechnology and Biological Sciences Research Council · United Kingdom
External Links
PubMed source DOI: 10.1038/nrmicro2198 View journal details
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