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PMID: 19527704 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

Nucleosome positioning: how is it established, and why does it matter?

Developmental biology ·Vol. 339 ·No. 2 ·2010-03-15 ·Pages 258-66

Radman-Livaja M, Rando OJ

Abstract

Packaging of eukaryotic genomes into chromatin affects every process that occurs on DNA. The positioning of nucleosomes on underlying DNA plays a key role in the regulation of these processes, as the nucleosome occludes underlying DNA sequences. Here, we review the literature on mapping nucleosome positions in various organisms, and discuss how nucleosome positions are established, what effect nucleosome positioning has on control of gene expression, and touch on the correlations between chromatin packaging, sequence evolution, and the evolution of gene expression programs.

MeSH Terms
Base Sequence Chromatin/metabolism Chromatin Assembly and Disassembly Epigenesis, Genetic Evolution, Molecular Gene Expression Regulation Genetic Variation Genomics Nuclear Proteins/genetics,metabolism Nucleosomes/metabolism Transcription, Genetic
Chemicals
Chromatin Nuclear Proteins Nucleosomes
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Radman-Livaja Marta
Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA 01605, USA.
Rando Oliver J
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Article Info
Journal
Developmental biology
Abbr.
Dev Biol
ISSN
1095-564X
DOI
10.1016/j.ydbio.2009.06.012
Published
2010-03-15
Epub
2009-00-13
Pages
258-66
Language
English
Region
United States
NLM ID
0372762
PMCID
PMC2830277
Subset
IM
Grants
NIGMS NIH HHS · R01 GM079205 · United States
NIGMS NIH HHS · R01 GM079205-01A2 · United States
NIGMS NIH HHS · R01 GM079205-02 · United States
External Links
PubMed source DOI: 10.1016/j.ydbio.2009.06.012 PMC Full Text View journal details
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