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PMID: 15166317 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Control of stochasticity in eukaryotic gene expression.

Science (New York, N.Y.) ·Vol. 304 ·No. 5678 ·2004-06-18 ·Pages 1811-4

Raser JM, O'Shea EK

Abstract

Noise, or random fluctuations, in gene expression may produce variability in cellular behavior. To measure the noise intrinsic to eukaryotic gene expression, we quantified the differences in expression of two alleles in a diploid cell. We found that such noise is gene-specific and not dependent on the regulatory pathway or absolute rate of expression. We propose a model in which the balance between promoter activation and transcription influences the variability in messenger RNA levels. To confirm the predictions of our model, we identified both cis- and trans-acting mutations that alter the noise of gene expression. These mutations suggest that noise is an evolvable trait that can be optimized to balance fidelity and diversity in eukaryotic gene expression.

MeSH Terms
Acid Phosphatase Alleles Bacterial Proteins/biosynthesis Carrier Proteins/genetics Cell Cycle Chromatin/metabolism Flow Cytometry Fluorescence Gene Expression Genes, Fungal Green Fluorescent Proteins Luminescent Proteins/biosynthesis Models, Genetic Mutation Promoter Regions, Genetic Proton-Phosphate Symporters/genetics RNA, Messenger/metabolism Saccharomyces cerevisiae/genetics,physiology Saccharomyces cerevisiae Proteins/genetics Stochastic Processes TATA Box Transcription, Genetic Transcriptional Activation
Chemicals
Bacterial Proteins Carrier Proteins Chromatin Luminescent Proteins PHO84 protein, S cerevisiae Proton-Phosphate Symporters RNA, Messenger Saccharomyces cerevisiae Proteins thiamine-binding protein yellow fluorescent protein, Bacteria Green Fluorescent Proteins Acid Phosphatase PHO3 protein, S cerevisiae PHO5 protein, S cerevisiae
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Raser Jonathan M
Department of Biochemistry and Biophysics, Howard Hughes Medical Institute, University of California-San Francisco (UCSF), 600 16th Street, Room S472D, San Francisco, CA 94143-2240, USA.
O'Shea Erin K
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Article Info
Journal
Science (New York, N.Y.)
Abbr.
Science
ISSN
1095-9203
Published
2004-06-18
Epub
2004-00-27
Pages
1811-4
Language
English
Region
United States
NLM ID
0404511
PMCID
PMC1410811
Subset
IM
Grants
NIGMS NIH HHS · R01 GM051377 · United States
NIGMS NIH HHS · GM51377 · United States
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