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PMID: 3399412 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Statistical distributions of nucleosomes: nonrandom locations by a stochastic mechanism.

Nucleic acids research ·Vol. 16 ·No. 14A ·1988-07-25 ·Pages 6677-90

Kornberg RD, Stryer L

Abstract

Expressions are derived for distributions of nucleosomes in chromatin. Nucleosomes are placed on DNA at the densities found in bulk chromatin, and their locations are allowed to vary at random. No further assumptions are required to simulate the periodic patterns of digestion obtained with various nucleases. The introduction of a boundary constraint, due for example to sequence-specific protein binding, results in an array of regularly spaced nucleosomes at nonrandom locations, similar to the arrays reported for some genes and other chromosomal regions.

MeSH Terms
Animals Chromatin/ultrastructure DNA Models, Theoretical Nucleosomes/physiology Stochastic Processes
Chemicals
Chromatin Nucleosomes DNA
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Kornberg R D
Department of Cell Biology, Stanford University School of Medicine, CA 94305.
Stryer L
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Article Info
Journal
Nucleic acids research
Abbr.
Nucleic Acids Res
ISSN
0305-1048
DOI
10.1093/nar/16.14.6677
Published
1988-07-25
Pages
6677-90
Language
English
Region
England
NLM ID
0411011
PMCID
PMC338322
Subset
IM
Grants
NIGMS NIH HHS · GM-30387 · United States
External Links
PubMed source DOI: 10.1093/nar/16.14.6677 PMC Full Text View journal details
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