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PMID: 1899927 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Amyloid precursor protein in aged nonhuman primates.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 88 ·No. 4 ·1991-02-15 ·Pages 1461-5

Martin LJ, Sisodia SS, Koo EH, Cork LC, Dellovade TL, Weidemann A, Beyreuther K, Masters C, Price DL

Abstract

In individuals with Alzheimer disease and in aged nonhuman primates, deposits of amyloid occur in senile plaques in brain parenchyma and in the walls of some meningeal and cortical vessels. Amyloid is primarily composed of beta/A4, a 4-kDa peptide derived from the transmembrane form of an amyloid precursor protein (APP). We examined the distribution of beta/A4 and APP (outside the beta/A4 domain) in cerebral cortices of monkeys ranging in age from 4 to 41 years. In all animals, APP immunoreactivity was present in cell bodies, proximal dendrites, and axons of cortical neurons. In aged animals, all of which showed senile plaques, large APP-positive axons were conspicuous, and APP immunoreactivity was present in neurites around beta/A4-immunoreactive plaques. In some plaques, APP-immunoreactive elements were located in proximity to deposits of beta/A4. The presence of APP immunoreactivity in neuronal perikarya, dendrites, axons, and in neurites within beta/A4-containing plaques supports the hypothesis that neurons can serve as one source of amyloid deposited in brain parenchyma.

MeSH Terms
Aging Amyloid beta-Peptides/analysis Amyloid beta-Protein Precursor Animals Axons/pathology,ultrastructure Brain/cytology,growth & development Brain Chemistry Immunoblotting Immunohistochemistry Macaca/growth & development Macaca mulatta/growth & development Organ Specificity Protease Inhibitors/analysis Protein Precursors/analysis
Chemicals
Amyloid beta-Peptides Amyloid beta-Protein Precursor Protease Inhibitors Protein Precursors
Authors & Affiliations
9 authors, click to expand affiliations / ORCID
Martin L J
Department of Pathology, University of Heidelberg, Federal Republic of Germany.
Sisodia S S
Koo E H
Cork L C
Dellovade T L
Weidemann A
Beyreuther K
Masters C
Price D L
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.88.4.1461
Published
1991-02-15
Pages
1461-5
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC51038
Subset
IM
Grants
NIA NIH HHS · AG 03359 · United States
NINDS NIH HHS · NS 07179 · United States
NINDS NIH HHS · NS 20471 · United States
External Links
PubMed source DOI: 10.1073/pnas.88.4.1461 PMC Full Text View journal details
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