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PMID: 3277189 Published · ppublish English Comparative Study Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Differential regulation of amyloid-beta-protein mRNA expression within hippocampal neuronal subpopulations in Alzheimer disease.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 85 ·No. 4 ·1988-02-00 ·Pages 1297-301

Higgins GA, Lewis DA, Bahmanyar S, Goldgaber D, Gajdusek DC, Young WG, Morrison JH, Wilson MC

Abstract

We have mapped the neuroanatomical distribution of amyloid-beta-protein mRNA within neuronal subpopulations of the hippocampal formation in the cynomolgus monkey (Macaca fascicularis), normal aged human, and patients with Alzheimer disease. Amyloid-beta-protein mRNA appears to be expressed in all hippocampal neurons, but at different levels of abundance. In the central nervous system of monkey and normal aged human, image analysis shows that neurons of the dentate gyrus and cornu Ammonis fields contain a 2.5-times-greater hybridization signal than is present in neurons of the subiculum and entorhinal cortex. In contrast, in the Alzheimer disease hippocampal formation, the levels of amyloid-beta-protein mRNA in the cornu Ammonis field 3 and parasubiculum are equivalent. These findings suggest that within certain neuronal subpopulations cell type-specific regulation of amyloid-beta-protein gene expression may be altered in Alzheimer disease.

MeSH Terms
Aged Aged, 80 and over Amyloid/biosynthesis Amyloid beta-Peptides Animals DNA/genetics Gene Expression Regulation Hippocampus/metabolism Humans Macaca fascicularis Male Neurons/classification,metabolism Nucleic Acid Hybridization RNA, Messenger/biosynthesis
Chemicals
Amyloid Amyloid beta-Peptides RNA, Messenger DNA
Authors & Affiliations
8 authors, click to expand affiliations / ORCID
Higgins G A
Department of Molecular Biology, Research Institute of Scripps Clinic, La Jolla, CA 92037.
Lewis D A
Bahmanyar S
Goldgaber D
Gajdusek D C
Young W G
Morrison J H
Wilson M C
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.85.4.1297
Published
1988-02-00
Pages
1297-301
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC279754
Subset
IM
Grants
NIA NIH HHS · AG 05131 · United States
NIMH NIH HHS · MH 00519 · United States
NINDS NIH HHS · NS 22347 · United States
External Links
PubMed source DOI: 10.1073/pnas.85.4.1297 PMC Full Text View journal details
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