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PMID: 2997667 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S.

Glutamic acid decarboxylase-like immunoreactive neurites in senile plaques.

Neuroscience letters ·Vol. 59 ·No. 2 ·1985-08-30 ·Pages 165-9

Walker LC, Kitt CA, Struble RG, Schmechel DE, Oertel WH, Cork LC, Price DL

Abstract

In the neocortex of an aged (26-year-old) rhesus monkey, a small percentage of abnormal neurites within some senile plaques (defined by the presence of amyloid) were immunoreactive for glutamic acid decarboxylase. This suggests that gamma-aminobutyric acid-synthesizing neurons may contribute to plaque formation in the aged brain.

MeSH Terms

Aging Amyloid/metabolism Animals Cerebral Cortex/enzymology,physiology Glutamate Decarboxylase/metabolism Immunoenzyme Techniques Macaca mulatta Synaptic Transmission gamma-Aminobutyric Acid/physiology

Chemicals

Amyloid gamma-Aminobutyric Acid Glutamate Decarboxylase

Authors & Affiliations

7 authors, click to expand affiliations / ORCID

Walker L C

Kitt C A

Struble R G

Schmechel D E

Oertel W H

Cork L C

Price D L

Article Info

Journal

Neuroscience letters

Abbr.

Neurosci Lett

ISSN

0304-3940

DOI

10.1016/0304-3940(85)90194-6

Published

1985-08-30

Pages

165-9

Language

English

Region

Ireland

NLM ID

7600130

Subset

Grants

NIA NIH HHS · AG 03359 · United States

NINDS NIH HHS · NS 07179 · United States

NINDS NIH HHS · NS 10580 · United States

External Links

PubMed source DOI: 10.1016/0304-3940(85)90194-6 View journal details

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Glutamic acid decarboxylase-like immunoreactive neurites in senile plaques.

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