Abstract
The cloned cDNA encoding the rat cognate of the human A4 amyloid precursor protein was isolated from a rat brain library. The predicted primary structure of the 695-amino acid-long protein displays 97% identity to its human homologue shown previously to resemble an integral membrane protein. The protein was detected in rodent brain and muscle by Western blot analysis. Using in situ hybridization and immunocytochemistry on rat brain sections, we discovered that rat amyloidogenic glycoprotein (rAG) and its mRNA are ubiquitously and abundantly expressed in neurons indicating a neuronal original for the amyloid deposits observed in humans with Alzheimer's disease (AD). The protein appears in patches on or near the plasma membranes of neurons suggesting a role for this protein in cell contact. Highest expression was seen in rat brain regions where amyloid is deposited in AD but also in areas which do not contain deposits in AD. Since amyloid deposits are rarely observed in rat brain, we conclude that high expression of AG is not the sole cause of amyloidosis.
MeSH Terms
Alzheimer Disease/genetics,metabolism
Amino Acid Sequence
Amyloid/genetics,metabolism
Amyloid beta-Protein Precursor
Animals
Base Sequence
Brain/cytology,metabolism
Cell Communication
Cell Membrane/metabolism
DNA/genetics
Molecular Sequence Data
Protein Precursors/genetics,metabolism
Rats
Tissue Distribution
Chemicals
Amyloid
Amyloid beta-Protein Precursor
Protein Precursors
DNA
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
Shivers B D
Zentrum für Molekulare Biologie, Universität Heidelberg, FRG.
Hilbich C
Multhaup G
Salbaum M
Beyreuther K
Seeburg P H
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