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PMID: 1845910 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Identification of a common viral integration region in Cas-Br-E murine leukemia virus-induced non-T-, non-B-cell lymphomas.

Journal of virology ·Vol. 65 ·No. 1 ·1991-01-00 ·Pages 7-15

Bergeron D, Poliquin L, Kozak CA, Rassart E

Abstract

The Cas-Br-E murine leukemia virus is a nondefective retrovirus that induces non-T-, non-B-cell lymphomas in susceptible NIH/Swiss mice. By using a DNA probe derived from Cas-Br-E provirus-flanking sequences, we identified a DNA region, originally called Sic-1, rearranged in 16 of 24 tumors analyzed (67%). All proviruses were integrated in a DNA segment smaller than 100 bp and were in the same 5'-to-3' orientation. Ecotropic as well as mink cell focus-forming virus types were found integrated in that specific DNA region. On the basis of Southern blot analysis of somatic cell hybrids and progeny of an interspecies backcross, the Sic-1 region was localized on mouse chromosome 9 near the previously described proto-oncogenes or common viral integration sites: Ets-1, Cbl-2, Tpl-1, and Fli-1. Restriction map analysis shows that this region is identical to the Fli-1 locus identified in Friend murine leukemia virus-induced erythroleukemia cell lines and thus may contain sequences also responsible for the development of mouse non-T-, non-B-cell lymphomas.

MeSH Terms
Animals Animals, Newborn Blotting, Southern Cloning, Molecular DNA Probes DNA, Neoplasm/genetics,isolation & purification DNA, Viral/genetics,isolation & purification Gene Rearrangement Immunoglobulin Heavy Chains/genetics Leukemia Virus, Murine/genetics,pathogenicity Lymphoma/genetics,microbiology Mice Mice, Inbred Strains Receptors, Antigen, T-Cell/genetics Restriction Mapping
Chemicals
DNA Probes DNA, Neoplasm DNA, Viral Immunoglobulin Heavy Chains Receptors, Antigen, T-Cell
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Bergeron D
Département des Sciences Biologiques, Université du Québec à Montréal, Canada.
Poliquin L
Kozak C A
Rassart E
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Article Info
Journal
Journal of virology
Abbr.
J Virol
ISSN
0022-538X
DOI
10.1128/JVI.65.1.7-15.1991
Published
1991-01-00
Pages
7-15
Language
English
Region
United States
NLM ID
0113724
PMCID
PMC240483
Subset
IM
External Links
PubMed source DOI: 10.1128/JVI.65.1.7-15.1991 PMC Full Text View journal details
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