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PMID: 6268845 Published · ppublish English Journal Article

Wild mouse ecotropic murine leukemia virus infection of inbred mice: dual-tropic virus expression precedes the onset of paralysis and lymphoma.

Journal of virology ·Vol. 39 ·No. 2 ·1981-08-00 ·Pages 597-602

Hoffman PM, Davidson WF, Ruscetti SK, Chused TM, Morse HC

Abstract

NFS/N mice inoculated at birth with an ecotropic murine leukemia virus (Cas-Br-MuLV) obtained from wild mice developed hind limb paralysis beginning at 7 weeks of age and nonthymic lymphomas beginning at more than 20 weeks of age. Studies of 1- to 7-week-old Cas-Br-M MuLV-infected mice showed the following: (i) a marked increase in nonecotropic MuLV-related antigens on spleen cells but not thymocytes beginning at 2 weeks; (ii) the appearance of dual-tropic mink cell focus-forming (MCF) MuLV-related gp70 in spleen but not thymus or brain cells at 4 weeks; and (iii) the isolation of infectious MCF MuLV from spleen cells of 7-week-old mice. A role for MCF MuLV in Cas-Br-M MuLV-induced nonthymic lymphomas is indicated by these studies, and a role for recombinant MuLV in neurological disease is considered.

MeSH Terms
Animals Antigens, Surface Antigens, Viral Glycoproteins/biosynthesis Leukemia Virus, Murine/growth & development,immunology Leukemia, Experimental/microbiology Lymphocytes/microbiology Lymphoma/etiology Mice Mice, Inbred Strains Paralysis/etiology Viral Proteins/biosynthesis
Chemicals
Antigens, Surface Antigens, Viral Glycoproteins Viral Proteins
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Hoffman P M
Davidson W F
Ruscetti S K
Chused T M
Morse H C
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20 references, click to expand
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Article Info
Journal
Journal of virology
Abbr.
J Virol
ISSN
0022-538X
DOI
10.1128/JVI.39.2.597-602.1981
Published
1981-08-00
Pages
597-602
Language
English
Region
United States
NLM ID
0113724
PMCID
PMC171369
Subset
IM
External Links
PubMed source DOI: 10.1128/JVI.39.2.597-602.1981 PMC Full Text View journal details
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