Lower limb paralysis induced in mice by a temperature-sensitive mutant of Moloney leukemia virus.

Journal of the National Cancer Institute ·Vol. 59 ·No. 1 ·1977-07-00 ·Pages 179-83

McCarter JA, Ball JK, Frei JV

Abstract

A temperature-sensitive mutant of Moloney murine leukemia virus defective in an early function and injected into newborn mice produced lower limb paralysis. Susceptible mice were inbred strains CFW/D, CBA/H, C3H/Bi/Ka, and outbred NIH Swiss stock. Inbred W/Fu rats and C57BL/Ka mice did not develop the paralysis, though the latter were infected with virus; the sera from these mice produced paralysis in susceptible CFW mice.

MeSH Terms

Animals Animals, Newborn Defective Viruses/isolation & purification Extremities Mice Mice, Inbred C3H Mice, Inbred C57BL Mice, Inbred CBA Mice, Inbred Strains Moloney murine leukemia virus/isolation & purification,pathogenicity Mutation Paralysis/etiology,microbiology,pathology Rats Rats, Inbred WF Spinal Cord/ultrastructure Temperature Tumor Virus Infections/pathology

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

McCarter J A

Ball J K

Frei J V

Article Info

Journal

Journal of the National Cancer Institute

Abbr.

J Natl Cancer Inst

ISSN

0027-8874

DOI

10.1093/jnci/59.1.179

Published

1977-07-00

Pages

179-83

Language

English

Region

United States

NLM ID

7503089

Subset

External Links

PubMed source DOI: 10.1093/jnci/59.1.179 View journal details

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Lower limb paralysis induced in mice by a temperature-sensitive mutant of Moloney leukemia virus.

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