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PMID: 2784003 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

v-cbl, an oncogene from a dual-recombinant murine retrovirus that induces early B-lineage lymphomas.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 86 ·No. 4 ·1989-02-00 ·Pages 1168-72

Langdon WY, Hartley JW, Klinken SP, Ruscetti SK, Morse HC

Abstract

Cas NS-1 is an acutely transforming murine retrovirus that induces pre-B and pro-B cell lymphomas. Molecular cloning showed it was generated from the ecotropic Cas-Br-M virus by sequential recombinations with endogenous retroviral sequences and a cellular oncogene. The oncogene sequence shows no homology with known oncogenes but some similarity to the yeast transcriptional activator GCN4. A 100-kDa gag-cbl fusion protein, with no detectable kinase activity, is responsible for the cellular transformation. The cellular homologue of v-cbl, present in mouse and human DNA, is expressed in a range of hemopoietic lineages.

MeSH Terms
Amino Acid Sequence Animals B-Lymphocytes Base Sequence Cell Transformation, Neoplastic Cells, Cultured Cloning, Molecular Lymphoma/genetics Mice Molecular Sequence Data Oncogene Protein v-cbl Oncogenes Rats Restriction Mapping Retroviridae/genetics Retroviridae Proteins/genetics Retroviridae Proteins, Oncogenic
Chemicals
Oncogene Protein v-cbl Retroviridae Proteins Retroviridae Proteins, Oncogenic
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Langdon W Y
Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital, Parkville, Victoria, Australia.
Hartley J W
Klinken S P
Ruscetti S K
Morse H C
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.86.4.1168
Published
1989-02-00
Pages
1168-72
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC286647
Subset
IM
Grants
NCI NIH HHS · CA 12421 · United States
PHS HHS · N01-A1-22673 · United States
Databases
GENBANK
J04169
External Links
PubMed source DOI: 10.1073/pnas.86.4.1168 PMC Full Text View journal details
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