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PMID: 17955391 Published · ppublish English Journal Article Review

Stem cells and cancer: an overview.

Stem cell reviews ·Vol. 3 ·No. 4 ·2007-12-00 ·Pages 249-55

Sales KM, Winslet MC, Seifalian AM

Abstract

Definite evidence of the importance of cancer stem cells in the progression of cancer has now come to light. Key markers of these cells have been identified in many solid tumours as well as leukaemias. Specific studies modelling the tumour induction of specific cells isolated by surface antigens such as CD44 have demonstrated that these cells are not only present in tumours but that they are the key units in their tumourgenecity. These findings provide useful insight for disease progression, treatment and metastasis. The wide variety of proposed markers, and their similarity to endothelial progenitor cells found in angiogenesis, complicates these studies. Definite proof falls only in the induction of tumours in vivo. Here we review the developments in cancer stem cells and the markers that have been found for these cells.

MeSH Terms
Adult Stem Cells/transplantation Animals Biomarkers, Tumor/metabolism Female Genetic Therapy/methods Humans Hyaluronan Receptors/metabolism Male Neoplasms/etiology,pathology,physiopathology,therapy Neoplastic Stem Cells/pathology,physiology
Chemicals
Biomarkers, Tumor Hyaluronan Receptors
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Sales Kevin M
Biomaterials & Tissue Engineering Centre, Academic Division of Surgical and Interventional Sciences, University College London, London, UK.
Winslet Marc C
Seifalian Alexander M
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Article Info
Journal
Stem cell reviews
Abbr.
Stem Cell Rev
ISSN
1550-8943
DOI
10.1007/s12015-007-9002-0
Published
2007-12-00
Pages
249-55
Language
English
Region
United States
NLM ID
101255952
Subset
IM
External Links
PubMed source DOI: 10.1007/s12015-007-9002-0 View journal details
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