Home LiteratureArticle Details
PMID: 17547749 Published · epublish English Journal Article

Role of stem cells in cancer therapy and cancer stem cells: a review.

Cancer cell international ·Vol. 7 ·2007-06-04 ·Pages 9

Sagar J, Chaib B, Sales K, Winslet M, Seifalian A

Abstract

For over 30 years, stem cells have been used in the replenishment of blood and immune systems damaged by the cancer cells or during treatment of cancer by chemotherapy or radiotherapy. Apart from their use in the immuno-reconstitution, the stem cells have been reported to contribute in the tissue regeneration and as delivery vehicles in the cancer treatments. The recent concept of 'cancer stem cells' has directed scientific communities towards a different wide new area of research field and possible potential future treatment modalities for the cancer. Aim of this review is primarily focus on the recent developments in the use of the stem cells in the cancer treatments, then to discuss the cancer stem cells, now considered as backbone in the development of the cancer; and their role in carcinogenesis and their implications in the development of possible new cancer treatment options in future.

Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Sagar Jayesh
Academic Department of Surgery, Royal Free Hospital, London, UK. jsagar_2001@yahoo.com
Chaib Boussad
Sales Kevin
Winslet Marc
Seifalian Alexander
References (127)
127 references, click to expand
  1. Ex vivo expanded peripheral blood progenitor cells provide rapid neutrophil recovery after high-dose chemotherapy in patients with breast cancer.
    Blood. 2000 Nov 1;96(9):3001-7 PMID: 11049977
  2. Immune reconstitution after allogeneic marrow transplantation compared with blood stem cell transplantation.
    Blood. 2001 Jun 1;97(11):3380-9 PMID: 11369627
  3. Preferential induction of apoptosis by interferon (IFN)-beta compared with IFN-alpha2: correlation with TRAIL/Apo2L induction in melanoma cell lines.
    Clin Cancer Res. 2001 Jun;7(6):1821-31 PMID: 11410525
  4. Purging of autologous peripheral-blood stem cells using CD34 selection does not improve overall or progression-free survival after high-dose chemotherapy for multiple myeloma: results of a multicenter randomized controlled trial.
    J Clin Oncol. 2001 Sep 1;19(17):3771-9 PMID: 11533101
  5. Stem cells, cancer, and cancer stem cells.
    Nature. 2001 Nov 1;414(6859):105-11 PMID: 11689955
  6. Negative regulation of neural stem/progenitor cell proliferation by the Pten tumor suppressor gene in vivo.
    Science. 2001 Dec 7;294(5549):2186-9 PMID: 11691952
  7. A genetic determinant that specifically regulates the frequency of hematopoietic stem cells.
    J Immunol. 2002 Jan 15;168(2):635-42 PMID: 11777956
  8. Residual tumor cell contamination in peripheral blood stem cells collections of 117 breast cancer patients evaluated by immunocytochemical technique.
    J Hematother Stem Cell Res. 2001 Dec;10(6):855-62 PMID: 11798511
  9. Collection of Philadelphia-negative stem cells using recombinant human granulocyte colony-stimulating factor in chronic myeloid leukemia patients treated with alpha-interferon.
    Haematologica. 2002 Jan;87(1):17-22 PMID: 11801461
  10. Negative selection of peripheral blood stem cells to support a tandem autologous transplantation programme in multiple myeloma.
    Br J Haematol. 2002 Jan;116(1):202-10 PMID: 11841418
  11. Ex vivo expansion of megakaryocyte progenitor cells from normal bone marrow and peripheral blood and from patients with haematological malignancies.
    Br J Haematol. 2002 Mar;116(4):912-9 PMID: 11886401
  12. Stem cell characteristics of human trabecular bone-derived cells.
    Bone. 2002 May;30(5):699-704 PMID: 11996907
  13. Telomerase expression extends the proliferative life-span and maintains the osteogenic potential of human bone marrow stromal cells.
    Nat Biotechnol. 2002 Jun;20(6):592-6 PMID: 12042863
  14. Pluripotency of mesenchymal stem cells derived from adult marrow.
    Nature. 2002 Jul 4;418(6893):41-9 PMID: 12077603
  15. Bone marrow-derived mesenchymal stem cells as vehicles for interferon-beta delivery into tumors.
    Cancer Res. 2002 Jul 1;62(13):3603-8 PMID: 12097260
  16. CD34+-enriched-CD19+-depleted autologous peripheral blood stem cell transplantation for chronic lymphoproliferative disorders: high purging efficiency but increased risk of severe infections.
    Exp Hematol. 2002 Jul;30(7):824-30 PMID: 12135682
  17. Oral melphalan at diagnosis hampers adequate collection of peripheral blood progenitor cells in multiple myeloma.
    Haematologica. 2002 Aug;87(8):846-50 PMID: 12161361
  18. A randomized multicenter comparison of bone marrow and peripheral blood in recipients of matched sibling allogeneic transplants for myeloid malignancies.
    Blood. 2002 Sep 1;100(5):1525-31 PMID: 12176866
  19. Cell-intrinsic differences between stem cells from different regions of the peripheral nervous system regulate the generation of neural diversity.
    Neuron. 2002 Aug 15;35(4):643-56 PMID: 12194865
  20. Medulloblastoma growth inhibition by hedgehog pathway blockade.
    Science. 2002 Aug 30;297(5586):1559-61 PMID: 12202832
  21. Preferential induction of apoptosis for primary human leukemic stem cells.
    Proc Natl Acad Sci U S A. 2002 Dec 10;99(25):16220-5 PMID: 12451177
  22. Granulocyte colony-stimulating factor administration upregulates telomerase activity in CD34+ haematopoietic cells and may prevent telomere attrition after chemotherapy.
    Br J Haematol. 2003 Jan;120(2):329-36 PMID: 12542495
  23. Mobilization of peripheral blood progenitor cells with a combination of cyclophosphamide, r-metHuSCF and filgrastim in patients with breast cancer previously treated with chemotherapy.
    Leukemia. 2003 Feb;17(2):437-41 PMID: 12592344
  24. Prospective identification of tumorigenic breast cancer cells.
    Proc Natl Acad Sci U S A. 2003 Apr 1;100(7):3983-8 PMID: 12629218
  25. Imatinib compared with interferon and low-dose cytarabine for newly diagnosed chronic-phase chronic myeloid leukemia.
    N Engl J Med. 2003 Mar 13;348(11):994-1004 PMID: 12637609
  26. Breast cancer stem cells revealed.
    Proc Natl Acad Sci U S A. 2003 Apr 1;100(7):3547-9 PMID: 12657737
  27. Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells.
    Nature. 2003 May 15;423(6937):302-5 PMID: 12714971
  28. SHED: stem cells from human exfoliated deciduous teeth.
    Proc Natl Acad Sci U S A. 2003 May 13;100(10):5807-12 PMID: 12716973
  29. Differences in heat sensitivity between normal and acute myeloid leukemic stem cells: feasibility of hyperthermic purging of leukemic cells from autologous stem cell grafts.
    Exp Hematol. 2003 May;31(5):421-7 PMID: 12763141
  30. Recovery of stromal stem cells in bone sarcoma patients after chemotherapy: implication for cell-based therapy in bone defect reconstruction.
    Oncol Rep. 2003 Jul-Aug;10(4):891-6 PMID: 12792741
  31. Comparison of multi-lineage cells from human adipose tissue and bone marrow.
    Cells Tissues Organs. 2003;174(3):101-9 PMID: 12835573
  32. Fewer relapses and increased chronic GVHD in patients transplanted with blood stem cells: a 5-year follow-up in a single centre study.
    Bone Marrow Transplant. 2003 Aug;32(3):257-64 PMID: 12858196
  33. Tissue-engineered cartilage and bone using stem cells from human infrapatellar fat pads.
    J Bone Joint Surg Br. 2003 Jul;85(5):740-7 PMID: 12892203
  34. Relationships of immunology to cancer: a review.
    Cancer Res. 1960 Apr;20:271-91 PMID: 13833075
  35. Isolation of multipotent mesenchymal stem cells from umbilical cord blood.
    Blood. 2004 Mar 1;103(5):1669-75 PMID: 14576065
  36. Immunotherapy of murine leukemia following non-myeloablative conditioning with naïve or G-CSF mobilized blood or bone marrow stem cells.
    Cancer Immunol Immunother. 2004 Apr;53(4):358-62 PMID: 14605765
  37. Cancerous stem cells can arise from pediatric brain tumors.
    Proc Natl Acad Sci U S A. 2003 Dec 9;100(25):15178-83 PMID: 14645703
  38. Exploitation of stem cell plasticity.
    Transfus Med. 2003 Dec;13(6):325-49 PMID: 14651740
  39. Single versus double autologous stem-cell transplantation for multiple myeloma.
    N Engl J Med. 2003 Dec 25;349(26):2495-502 PMID: 14695409
  40. Maintenance of differentiation potential of human bone marrow mesenchymal stem cells immortalized by human telomerase reverse transcriptase gene despite [corrected] extensive proliferation.
    Biochem Biophys Res Commun. 2005 Jan 21;326(3):527-38 PMID: 15596132
  41. Autologous bone marrow transplantation as consolidation therapy in the treatment of adult patients under 60 years with acute myeloid leukaemia in first complete remission: a prospective randomized Dutch-Belgian Haemato-Oncology Co-operative Group (HOVON) and Swiss Group for Clinical Cancer Research (SAKK) trial.
    Br J Haematol. 2005 Jan;128(1):59-65 PMID: 15606550
  42. Telomerase extends a helping hand to progenitor cells.
    Trends Biotechnol. 2005 Jan;23(1):1-3 PMID: 15629847
  43. Up-front tandem high-dose chemotherapy compared with standard chemotherapy with doxorubicin and paclitaxel in metastatic breast cancer: results of a randomized trial.
    J Clin Oncol. 2005 Jan 20;23(3):432-40 PMID: 15659490
  44. Randomized trial of allogeneic related bone marrow transplantation versus peripheral blood stem cell transplantation for chronic myeloid leukemia.
    Biol Blood Marrow Transplant. 2005 Feb;11(2):85-92 PMID: 15682068
  45. Prospective, randomized comparison of high-dose chemotherapy with stem-cell support versus intermediate-dose chemotherapy after surgery and adjuvant chemotherapy in women with high-risk primary breast cancer: a report of CALGB 9082, SWOG 9114, and NCIC MA-13.
    J Clin Oncol. 2005 Apr 1;23(10):2191-200 PMID: 15767638
  46. Mesenchymal stem cells (MSC) as therapeutic cytoreagents for gene therapy.
    Cancer Sci. 2005 Mar;96(3):149-56 PMID: 15771617
  47. Human bone marrow-derived mesenchymal stem cells in the treatment of gliomas.
    Cancer Res. 2005 Apr 15;65(8):3307-18 PMID: 15833864
  48. The Sca-1 cell surface marker enriches for a prostate-regenerating cell subpopulation that can initiate prostate tumorigenesis.
    Proc Natl Acad Sci U S A. 2005 May 10;102(19):6942-7 PMID: 15860580
  49. Autologous bone marrow stem cell mobilization induced by granulocyte colony-stimulating factor after subacute ST-segment elevation myocardial infarction undergoing late revascularization: final results from the G-CSF-STEMI (Granulocyte Colony-Stimulating Factor ST-Segment Elevation Myocardial Infarction) trial.
    J Am Coll Cardiol. 2006 Oct 17;48(8):1712-21 PMID: 17045910
  50. Intramyocardial implantation of CD133+ stem cells improved cardiac function without bypass surgery.
    Heart Surg Forum. 2007;10(1):E66-9 PMID: 17162408
  51. Intracoronary infusion of the mobilized peripheral blood stem cell by G-CSF is better than mobilization alone by G-CSF for improvement of cardiac function and remodeling: 2-year follow-up results of the Myocardial Regeneration and Angiogenesis in Myocardial Infarction with G-CSF and Intra-Coronary Stem Cell Infusion (MAGIC Cell) 1 trial.
    Am Heart J. 2007 Feb;153(2):237.e1-8 PMID: 17239682
  52. Heredity and cancer in man.
    Prog Med Genet. 1973;9:113-58 PMID: 4351406
  53. Mouse myeloma tumor stem cells: a primary cell culture assay.
    J Natl Cancer Inst. 1971 Feb;46(2):411-22 PMID: 5115909
  54. The essential cells of the hemopoietic microenvironment.
    Exp Hematol. 1984 Aug;12(7):517-21 PMID: 6745328
  55. Peripheral blood stem cell transplants for multiple myeloma: identification of favorable variables for rapid engraftment in 225 patients.
    Blood. 1995 Jan 15;85(2):588-96 PMID: 7529066
  56. Matrix molecule interactions with hematopoietic stem cells.
    Exp Hematol. 1995 Aug;23(9):961-7 PMID: 7635183
  57. New strategies in marrow purging for breast cancer patients receiving high-dose chemotherapy with autologous bone marrow transplantation.
    Breast Cancer Res Treat. 1993;26 Suppl:S19-23 PMID: 7691269
  58. Mechanism of interferon beta-induced squamous differentiation and programmed cell death in human non-small-cell lung cancer cell lines.
    J Natl Cancer Inst. 1995 Feb 1;87(3):206-12 PMID: 7707408
  59. Detection and viability of tumor cells in peripheral blood stem cell collections from breast cancer patients using immunocytochemical and clonogenic assay techniques.
    Blood. 1993 Nov 1;82(9):2605-10 PMID: 8219214
  60. Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr-Abl positive cells.
    Nat Med. 1996 May;2(5):561-6 PMID: 8616716
  61. Prospective, randomized trial of 5-fluorouracil, leucovorin, doxorubicin, and cyclophosphamide chemotherapy in combination with the interleukin-3/granulocyte-macrophage colony-stimulating factor (GM-CSF) fusion protein (PIXY321) versus GM-CSF in patients with advanced breast cancer.
    Blood. 1996 Mar 15;87(6):2205-11 PMID: 8630380
  62. Use of amifostine in bone marrow purging.
    Semin Oncol. 1996 Aug;23(4 Suppl 8):44-8 PMID: 8783666
  63. Similar breast cancer cell contamination of single-day peripheral-blood progenitor-cell collections obtained after priming with hematopoietic growth factor alone or after cyclophosphamide followed by growth factor.
    J Clin Oncol. 1996 Sep;14(9):2569-75 PMID: 8823337
  64. Rapid immunologic reconstitution following transplantation with mobilized peripheral blood stem cells as compared to bone marrow.
    Bone Marrow Transplant. 1997 Jan;19(2):161-72 PMID: 9116614
  65. Induction of multiple programmed cell death pathways by IFN-beta in human non-small-cell lung cancer cell lines.
    Exp Cell Res. 1999 Feb 25;247(1):133-41 PMID: 10047455
  66. Multicenter phase III trial to evaluate CD34(+) selected versus unselected autologous peripheral blood progenitor cell transplantation in multiple myeloma.
    Blood. 1999 Mar 15;93(6):1858-68 PMID: 10068658
  67. A single apheresis to achieve a high number of peripheral blood CD34+ cells in a lithium-treated patient with acute myeloid leukaemia.
    Bone Marrow Transplant. 1999 Feb;23(3):305 PMID: 10084266
  68. Multilineage potential of adult human mesenchymal stem cells.
    Science. 1999 Apr 2;284(5411):143-7 PMID: 10102814
  69. Recombinant human thrombopoietin in combination with granulocyte colony-stimulating factor enhances mobilization of peripheral blood progenitor cells, increases peripheral blood platelet concentration, and accelerates hematopoietic recovery following high-dose chemotherapy.
    Blood. 1999 May 1;93(9):2798-806 PMID: 10216073
  70. Tumour cell detection in G-CSF mobilised stem cell harvests of patients with breast cancer.
    Med Oncol. 1999 Apr;16(1):17-22 PMID: 10382938
  71. Peripheral blood vs bone marrow as a source for allogeneic hematopoietic stem cell transplantation.
    Bone Marrow Transplant. 1999 Aug;24(4):355-8 PMID: 10467322
  72. Ex vivo pharmacological purging of leukapheresis collections with nitrogen mustard: amifostine pretreatment improves both early and late peripheral blood progenitor cell recovery.
    Exp Hematol. 1999 Oct;27(10):1548-56 PMID: 10517497
  73. Monitoring chronic myeloid leukaemia therapy by real-time quantitative PCR in blood is a reliable alternative to bone marrow cytogenetics.
    Br J Haematol. 1999 Dec;107(3):587-99 PMID: 10583264
  74. Cell cycle status and apoptosis of hematopoietic progenitor cells released into the peripheral blood after taxanes and granulocyte colony-stimulating factor in breast cancer patients.
    Oncol Rep. 2000 May-Jun;7(3):585-9 PMID: 10767372
  75. Allogeneic blood and bone-marrow stem-cell transplantation in haematological malignant diseases: a randomised trial.
    Lancet. 2000 Apr 8;355(9211):1231-7 PMID: 10770306
  76. The removal of human breast cancer cells from hematopoietic CD34+ stem cells by dielectrophoretic field-flow-fractionation.
    J Hematother Stem Cell Res. 1999 Oct;8(5):481-90 PMID: 10791899
  77. Systematic reviews of chemotherapy and endocrine therapy in metastatic breast cancer.
    Cancer Treat Rev. 2000 Jun;26(3):151-68 PMID: 10814559
  78. Similar MLL-associated leukemias arising from self-renewing stem cells and short-lived myeloid progenitors.
    Genes Dev. 2003 Dec 15;17(24):3029-35 PMID: 14701873
  79. Stem cells: review and update.
    Arch Surg. 2004 Jan;139(1):93-9 PMID: 14718284
  80. Human acute myeloid leukemia stem cells.
    Arch Med Res. 2003 Nov-Dec;34(6):507-14 PMID: 14734090
  81. Biology of the hemopoietic microenvironment.
    Eur J Haematol. 1992 Nov;49(5):225-33 PMID: 1473584
  82. Chondrogenic potential of multipotential cells from human adipose tissue.
    Plast Reconstr Surg. 2004 Feb;113(2):585-94 PMID: 14758221
  83. Chondrogenic differentiation of adipose-derived adult stem cells in agarose, alginate, and gelatin scaffolds.
    Biomaterials. 2004 Jul;25(16):3211-22 PMID: 14980416
  84. Infectious complications in patients randomized to receive allogeneic bone marrow or peripheral blood transplantation.
    Transpl Infect Dis. 2003 Dec;5(4):167-73 PMID: 14987200
  85. Telomerase immortalization of neuronally restricted progenitor cells derived from the human fetal spinal cord.
    Nat Biotechnol. 2004 Mar;22(3):297-305 PMID: 14990951
  86. Immortalization without neoplastic transformation of human mesenchymal stem cells by transduction with HPV16 E6/E7 genes.
    Int J Cancer. 2004 Jun 20;110(3):313-9 PMID: 15095294
  87. Adult human mesenchymal stem cell as a target for neoplastic transformation.
    Oncogene. 2004 Jun 24;23(29):5095-8 PMID: 15107831
  88. Therapeutic implications of cancer stem cells.
    Curr Opin Genet Dev. 2004 Feb;14(1):43-7 PMID: 15108804
  89. Induction of apoptosis and effect on CD20+ using rituximab on autologous peripheral blood stem cell harvests from patients with B cell lymphomas.
    Stem Cells Dev. 2004 Apr;13(2):193-6 PMID: 15186735
  90. Stem cell origin of cancer and differentiation therapy.
    Crit Rev Oncol Hematol. 2004 Jul;51(1):1-28 PMID: 15207251
  91. Flowing cells through pulsed electric fields efficiently purges stem cell preparations of contaminating myeloma cells while preserving stem cell function.
    Blood. 2005 Mar 1;105(5):2235-8 PMID: 15292069
  92. Granulocyte-macrophage progenitors as candidate leukemic stem cells in blast-crisis CML.
    N Engl J Med. 2004 Aug 12;351(7):657-67 PMID: 15306667
  93. Noninvasive MR imaging of magnetically labeled stem cells to directly identify neovasculature in a glioma model.
    Blood. 2005 Jan 1;105(1):420-5 PMID: 15331444
  94. Isolation and characterization of tumorigenic, stem-like neural precursors from human glioblastoma.
    Cancer Res. 2004 Oct 1;64(19):7011-21 PMID: 15466194
  95. Mesenchymal stem cells: potential precursors for tumor stroma and targeted-delivery vehicles for anticancer agents.
    J Natl Cancer Inst. 2004 Nov 3;96(21):1593-603 PMID: 15523088
  96. Tissue repair and stem cell renewal in carcinogenesis.
    Nature. 2004 Nov 18;432(7015):324-31 PMID: 15549094
  97. Primitive acute myeloid leukemia cells with long-term proliferative ability in vitro and in vivo lack surface expression of c-kit (CD117).
    Exp Hematol. 2000 Jun;28(6):660-71 PMID: 10880752
  98. Human acute myeloid leukemia CD34+/CD38- progenitor cells have decreased sensitivity to chemotherapy and Fas-induced apoptosis, reduced immunogenicity, and impaired dendritic cell transformation capacities.
    Cancer Res. 2000 Aug 15;60(16):4403-11 PMID: 10969785
  99. Osteogenic progenitor cell potency after high-dose chemotherapy (COSS-96).
    Anticancer Res. 2005 Mar-Apr;25(2A):947-54 PMID: 15868932
  100. A randomised trial of high-dose chemotherapy in the salvage treatment of patients failing first-line platinum chemotherapy for advanced germ cell tumours.
    Ann Oncol. 2005 Jul;16(7):1152-9 PMID: 15928070
  101. Stem cell division is regulated by the microRNA pathway.
    Nature. 2005 Jun 16;435(7044):974-8 PMID: 15944714
  102. Identification of bronchioalveolar stem cells in normal lung and lung cancer.
    Cell. 2005 Jun 17;121(6):823-35 PMID: 15960971
  103. Cost effectiveness of day 5 G-CSF (Lenograstim) administration after PBSC transplantation: results of a SFGM-TC randomised trial.
    Bone Marrow Transplant. 2005 Sep;36(6):547-52 PMID: 16007101
  104. Normal and neoplastic stem cells.
    Novartis Found Symp. 2005;265:35-50; discussion 50-4, 92-7 PMID: 16050249
  105. Cancer stem cells: lessons from leukemia.
    Trends Cell Biol. 2005 Sep;15(9):494-501 PMID: 16084092
  106. Chemotherapy versus allogeneic transplantation for very-high-risk childhood acute lymphoblastic leukaemia in first complete remission: comparison by genetic randomisation in an international prospective study.
    Lancet. 2005 Aug 20-26;366(9486):635-42 PMID: 16112299
  107. Stem cells and brain cancer.
    Cell Death Differ. 2006 Jan;13(1):5-11 PMID: 16123777
  108. Myeloablative megatherapy with autologous stem-cell rescue versus oral maintenance chemotherapy as consolidation treatment in patients with high-risk neuroblastoma: a randomised controlled trial.
    Lancet Oncol. 2005 Sep;6(9):649-58 PMID: 16129365
  109. High-dose therapy and autologous blood stem-cell transplantation compared with conventional treatment in myeloma patients aged 55 to 65 years: long-term results of a randomized control trial from the Group Myelome-Autogreffe.
    J Clin Oncol. 2005 Dec 20;23(36):9227-33 PMID: 16275936
  110. Cancer stem cells.
    Neoplasma. 2005;52(6):435-40 PMID: 16284686
  111. Comparison of rapidly cycled tandem high-dose chemotherapy plus peripheral-blood stem-cell support versus dose-dense conventional chemotherapy for adjuvant treatment of high-risk breast cancer: results of a multicentre phase III trial.
    Lancet. 2005 Dec 3;366(9501):1935-44 PMID: 16325695
  112. Gene therapy: can neural stem cells deliver?
    Nat Rev Neurosci. 2006 Jan;7(1):75-84 PMID: 16371952
  113. Epidermal stem cells and cancer stem cells: insights into cancer and potential therapeutic strategies.
    Eur J Cancer. 2006 Jun;42(9):1283-92 PMID: 16679013
  114. Cancer stem cells.
    N Engl J Med. 2006 Sep 21;355(12):1253-61 PMID: 16990388
  115. Identification of human brain tumour initiating cells.
    Nature. 2004 Nov 18;432(7015):396-401 PMID: 15549107
  116. Isolation of cancer stem cells from adult glioblastoma multiforme.
    Oncogene. 2004 Dec 16;23(58):9392-400 PMID: 15558011
  117. Stem cells today: B1. Bone marrow stem cells.
    Reprod Biomed Online. 2004 Nov;9(5):541-83 PMID: 15588475
  118. Early consolidation by myeloablative radiochemotherapy followed by autologous stem cell transplantation in first remission significantly prolongs progression-free survival in mantle-cell lymphoma: results of a prospective randomized trial of the European MCL Network.
    Blood. 2005 Apr 1;105(7):2677-84 PMID: 15591112
  119. Lack of expression of Thy-1 (CD90) on acute myeloid leukemia cells with long-term proliferative ability in vitro and in vivo.
    Blood. 1997 May 1;89(9):3104-12 PMID: 9129012
  120. Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell.
    Nat Med. 1997 Jul;3(7):730-7 PMID: 9212098
  121. Role of tumor cells contaminating the graft in breast cancer recurrence after high-dose chemotherapy.
    Bone Marrow Transplant. 1997 Jul;20(2):167-9 PMID: 9244422
  122. Advances in the clinical use of granulocyte colony-stimulating factor and granulocyte-macrophage colony-stimulating factor to intensify cancer chemotherapy.
    Curr Opin Hematol. 1994 May;1(3):221-7 PMID: 9371286
  123. Extension of life-span by introduction of telomerase into normal human cells.
    Science. 1998 Jan 16;279(5349):349-52 PMID: 9454332
  124. [Immune reconstitution after autologous progenitor hemopoietic cell transplantation. A study comparing autologous bone marrow and autologous peripheral blood transplantation].
    Med Clin (Barc). 1998 Jun 6;110(20):768-73 PMID: 9666417
  125. Post-chemotherapy and cytokine pretreated marrow stromal cell layers suppress hematopoiesis from normal donor CD34+ cells.
    Bone Marrow Transplant. 1998 Sep;22(5):457-68 PMID: 9733269
  126. Embryonic stem cell lines derived from human blastocysts.
    Science. 1998 Nov 6;282(5391):1145-7 PMID: 9804556
  127. Occult tumor contamination of hematopoietic stem-cell products does not affect clinical outcome of autologous transplantation in patients with metastatic breast cancer.
    J Clin Oncol. 1998 Nov;16(11):3509-17 PMID: 9817268
Article Info
Journal
Cancer cell international
Abbr.
Cancer Cell Int
ISSN
1475-2867
DOI
10.1186/1475-2867-7-9
Email
jsagar_2001@yahoo.com
Published
2007-06-04
Epub
2007-00-04
Pages
9
Language
English
Region
England
NLM ID
101139795
PMCID
PMC1894783
External Links
PubMed source DOI: 10.1186/1475-2867-7-9 PMC Full Text View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: product@genelibs.com

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2