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PMID: 16300650 Published · ppublish English Journal Article Review

Prostate epithelial stem cells.

Cell proliferation ·Vol. 38 ·No. 6 ·2005-12-00 ·Pages 363-74

Rizzo S, Attard G, Hudson DL

Abstract

The prostate gland is the site of the most commonly diagnosed cancer in men in USA and UK, accounting for one in five of new cases of male cancer. Common with many other cancer types, prostate cancer is believed to arise from a stem cell that shares characteristics with the normal stem cell. Normal prostate epithelial stem cells were recently identified and found to have a basal cell phenotype together with expression of CD133. Preliminary data have now emerged for a prostate cancer stem cell that also expresses cell surface CD133 but lacks expression of the androgen receptor. Here we examine the evidence supporting the existence of prostate cancer stem cells and discuss possible mechanisms of stem cell maintenance.

MeSH Terms
Animals Epithelial Cells/pathology Humans Male Prostate/cytology,pathology Prostatic Neoplasms/pathology Stem Cells/pathology
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Rizzo S
The Bob Champion Prostate Stem Cell Laboratory, Institute of Cancer Research, 15 Cotswold Road, Sutton, Surrey, UK, SM2 5NG.
Attard G
Hudson D L
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Article Info
Journal
Cell proliferation
Abbr.
Cell Prolif
ISSN
0960-7722
DOI
10.1111/j.1365-2184.2005.00356.x
Published
2005-12-00
Pages
363-74
Language
English
Region
England
NLM ID
9105195
PMCID
PMC6496238
Subset
IM
External Links
PubMed source DOI: 10.1111/j.1365-2184.2005.00356.x PMC Full Text View journal details
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