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PMID: 16643604 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

Cancer stem cells in human gastrointestinal cancers.

Human cell ·Vol. 19 ·No. 1 ·2006-02-00 ·Pages 24-9

Haraguchi N, Inoue H, Tanaka F, Mimori K, Utsunomiya T, Sasaki A, Mori M

Abstract

The concept of cancer stem cell has developed in leukemia. Recently, it has expanded to include solid tumors such as brain or breast tumors. However, the descriptions are not recognized in human gastrointestinal cancers. We used flow cytometry and the DNA-binding dye (Hoechst 33342) to isolate side population (SP) cells from various human gastrointestinal system cancer cell lines. The SP cell fraction is considered to contain abundant stem cells. Fifteen of 16 cancer cell lines from the gastrointestinal system contained 0.3-2.2% SP cells. We studied the characteristics of the SP cells in hepatic or colon cancer cell lines. The results demonstrated that cancers of the gastrointestinal system do contain SP cells that show some characters of so-called stem cells. In this paper, we report our study results with a review of the literature.

MeSH Terms

ATP-Binding Cassette Transporters Carcinoma, Hepatocellular/pathology Cell Differentiation Cell Division Cell Line, Tumor Cell Separation Colonic Neoplasms/pathology Drug Resistance, Neoplasm Flow Cytometry Gastrointestinal Neoplasms/pathology Humans Liver Neoplasms/pathology Neoplastic Stem Cells/cytology,drug effects

Chemicals

ATP-Binding Cassette Transporters

Authors & Affiliations

7 authors, click to expand affiliations / ORCID

Haraguchi Naotsugu

Department of Surgery, Medical Institute of Bioregulation, Kyushu University, Tsurumihara 4546, Beppu 874-0838, Japan.

Inoue Hiroshi

Tanaka Fumiaki

Mimori Koshi

Utsunomiya Tohru

Sasaki Atsushi

Mori Masaki

References (25)

25 references, click to expand

Regulation of embryonic stem cell self-renewal by phosphoinositide 3-kinase-dependent signaling.
J Biol Chem. 2004 Nov 12;279(46):48063-70 PMID: 15328362
GATA6 regulates HNF4 and is required for differentiation of visceral endoderm in the mouse embryo.
Genes Dev. 1998 Nov 15;12(22):3579-90 PMID: 9832509
Identification of bipotential progenitor cells in human liver development.
Hepatology. 1996 Mar;23(3):476-81 PMID: 8617427
Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell.
Nat Med. 1997 Jul;3(7):730-7 PMID: 9212098
Identification of human brain tumour initiating cells.
Nature. 2004 Nov 18;432(7015):396-401 PMID: 15549107
Isolation of cancer stem cells from adult glioblastoma multiforme.
Oncogene. 2004 Dec 16;23(58):9392-400 PMID: 15558011
CEACAM6 gene silencing impairs anoikis resistance and in vivo metastatic ability of pancreatic adenocarcinoma cells.
Oncogene. 2004 Jan 15;23(2):465-73 PMID: 14724575
A distinct "side population" of cells with high drug efflux capacity in human tumor cells.
Proc Natl Acad Sci U S A. 2004 Sep 28;101(39):14228-33 PMID: 15381773
Stem cells, cancer, and cancer stem cells.
Nature. 2001 Nov 1;414(6859):105-11 PMID: 11689955
Applying the principles of stem-cell biology to cancer.
Nat Rev Cancer. 2003 Dec;3(12):895-902 PMID: 14737120
Genomic expression analysis implicates Wnt signaling pathway and extracellular matrix alterations in hepatic specification and differentiation of murine hepatic stem cells.
Differentiation. 2001 Oct;68(4-5):254-69 PMID: 11776478
Tissue repair and stem cell renewal in carcinogenesis.
Nature. 2004 Nov 18;432(7015):324-31 PMID: 15549094
Tumour stem cells and drug resistance.
Nat Rev Cancer. 2005 Apr;5(4):275-84 PMID: 15803154
Dye efflux studies suggest that hematopoietic stem cells expressing low or undetectable levels of CD34 antigen exist in multiple species.
Nat Med. 1997 Dec;3(12):1337-45 PMID: 9396603
Transcriptional activation of BMP-4 and regulation of mammalian organogenesis by GATA-4 and -6.
Dev Biol. 2003 Feb 1;254(1):131-48 PMID: 12606287
Prospective identification of tumorigenic breast cancer cells.
Proc Natl Acad Sci U S A. 2003 Apr 1;100(7):3983-8 PMID: 12629218
Persistence of a small subpopulation of cancer stem-like cells in the C6 glioma cell line.
Proc Natl Acad Sci U S A. 2004 Jan 20;101(3):781-6 PMID: 14711994
A cell initiating human acute myeloid leukaemia after transplantation into SCID mice.
Nature. 1994 Feb 17;367(6464):645-8 PMID: 7509044
Association of Vimentin overexpression and hepatocellular carcinoma metastasis.
Oncogene. 2004 Jan 8;23(1):298-302 PMID: 14647434
GATA6 is essential for embryonic development of the liver but dispensable for early heart formation.
Mol Cell Biol. 2005 Apr;25(7):2622-31 PMID: 15767668
Cancerous stem cells can arise from pediatric brain tumors.
Proc Natl Acad Sci U S A. 2003 Dec 9;100(25):15178-83 PMID: 14645703
Prediction of sensitivity of advanced non-small cell lung cancers to gefitinib (Iressa, ZD1839).
Hum Mol Genet. 2004 Dec 15;13(24):3029-43 PMID: 15496427
A leukemic stem cell with intrinsic drug efflux capacity in acute myeloid leukemia.
Blood. 2001 Aug 15;98(4):1166-73 PMID: 11493466
A novel role for carcinoembryonic antigen-related cell adhesion molecule 6 as a determinant of gemcitabine chemoresistance in pancreatic adenocarcinoma cells.
Cancer Res. 2004 Jun 1;64(11):3987-93 PMID: 15173012
Origin and characterization of a human bipotent liver progenitor cell line.
Gastroenterology. 2004 Apr;126(4):1147-56 PMID: 15057753

Article Info

Journal

Human cell

Abbr.

Hum Cell

ISSN

0914-7470

DOI

10.1111/j.1749-0774.2005.00004.x

Published

2006-02-00

Pages

24-9

Language

English

Region

Japan

NLM ID

8912329

Subset

External Links

PubMed source DOI: 10.1111/j.1749-0774.2005.00004.x View journal details

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