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PMID: 17488587 Published · ppublish English Journal Article Review

Brain tumor stem cells.

Current neurology and neuroscience reports ·Vol. 7 ·No. 3 ·2007-05-00 ·Pages 215-20

Panagiotakos G, Tabar V

Abstract

The concept of brain tumor stem cells is gaining increased recognition in neuro-oncology. Until recently, the paradigm of a tumor-initiating stem cell was confined to hematopoietic malignancies where the hierarchical lineages of stem progenitor cells are well established. The demonstration of persistent stem cells and cycling progenitors in the adult brain, coupled with the expansion of the cancer stem cell concept to solid tumors, has led to the exploration of "stemness" within gliomas. Emerging data are highly suggestive of the subsistence of transformed multipotential cells within a glioma, with a subfraction of cells exhibiting increased efficiency at tumor initiation. However, data in support of true glioma stem cells are inconclusive to date, particularly with respect to functional characterization of these cells. Ongoing work aims at the identification of unique pathways governing self-renewal of these putative stem cells and at their validation as ultimate therapeutic targets.

MeSH Terms
Animals Brain Neoplasms/pathology Cell Differentiation Cell Transformation, Neoplastic Humans Neoplastic Stem Cells/cytology,physiology
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Panagiotakos Georgia
Division of Neurosurgery, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, C711, New York, NY 10021, USA.
Tabar Viviane
References (54)
54 references, click to expand
  1. Glial progenitors in adult white matter are driven to form malignant gliomas by platelet-derived growth factor-expressing retroviruses.
    J Neurosci. 2006 Jun 21;26(25):6781-90 PMID: 16793885
  2. Neurogenesis and plasticity in the CNS of adult birds.
    Exp Neurol. 1992 Jan;115(1):110-4 PMID: 1728556
  3. Human cortical glial tumors contain neural stem-like cells expressing astroglial and neuronal markers in vitro.
    Glia. 2002 Sep;39(3):193-206 PMID: 12203386
  4. The importance of implantation site in cerebral carcinogenesis in rats.
    Cancer Res. 1969 Nov;29(11):1927-31 PMID: 4311561
  5. Overexpression of c-MYC promotes an undifferentiated phenotype in cultured astrocytes and allows elevated Ras and Akt signaling to induce gliomas from GFAP-expressing cells in mice.
    Neuron Glia Biol. 2004 May;1(2):157-63 PMID: 17047730
  6. Brain tumors.
    N Engl J Med. 2001 Jan 11;344(2):114-23 PMID: 11150363
  7. PDGFR alpha-positive B cells are neural stem cells in the adult SVZ that form glioma-like growths in response to increased PDGF signaling.
    Neuron. 2006 Jul 20;51(2):187-99 PMID: 16846854
  8. The role of the subependymal plate in avian sarcoma virus brain tumor induction: comparison of incipient tumors in neonatal and adult rats.
    Acta Neuropathol. 1977 Apr 29;38(1):1-6 PMID: 193346
  9. Applying the principles of stem-cell biology to cancer.
    Nat Rev Cancer. 2003 Dec;3(12):895-902 PMID: 14737120
  10. Both oligodendrocytes and astrocytes develop from progenitors in the subventricular zone of postnatal rat forebrain.
    Neuron. 1993 Feb;10(2):201-12 PMID: 8439409
  11. Brain tumour stem cells.
    Nat Rev Cancer. 2006 Jun;6(6):425-36 PMID: 16723989
  12. Cellular composition and cytoarchitecture of the adult human subventricular zone: a niche of neural stem cells.
    J Comp Neurol. 2006 Jan 20;494(3):415-34 PMID: 16320258
  13. The long-term repopulating subset of hematopoietic stem cells is deterministic and isolatable by phenotype.
    Immunity. 1994 Nov;1(8):661-73 PMID: 7541305
  14. Subventricular zone astrocytes are neural stem cells in the adult mammalian brain.
    Cell. 1999 Jun 11;97(6):703-16 PMID: 10380923
  15. Neural stem cells display extensive tropism for pathology in adult brain: evidence from intracranial gliomas.
    Proc Natl Acad Sci U S A. 2000 Nov 7;97(23):12846-51 PMID: 11070094
  16. Combined activation of Ras and Akt in neural progenitors induces glioblastoma formation in mice.
    Nat Genet. 2000 May;25(1):55-7 PMID: 10802656
  17. Cancerous stem cells can arise from pediatric brain tumors.
    Proc Natl Acad Sci U S A. 2003 Dec 9;100(25):15178-83 PMID: 14645703
  18. Stem and progenitor cells: origins, phenotypes, lineage commitments, and transdifferentiations.
    Annu Rev Cell Dev Biol. 2001;17:387-403 PMID: 11687494
  19. Neurogenesis in the adult brain.
    J Neurosci. 2002 Feb 1;22(3):612-3 PMID: 11826087
  20. The role of the subependymal plate in glial tumorigenesis.
    Acta Neuropathol. 1977 Sep 26;40(1):63-71 PMID: 199034
  21. Generation of neurons and astrocytes from isolated cells of the adult mammalian central nervous system.
    Science. 1992 Mar 27;255(5052):1707-10 PMID: 1553558
  22. Stem cells: units of development, units of regeneration, and units in evolution.
    Cell. 2000 Jan 7;100(1):157-68 PMID: 10647940
  23. Notch signalling regulates stem cell numbers in vitro and in vivo.
    Nature. 2006 Aug 17;442(7104):823-6 PMID: 16799564
  24. Cellular composition and three-dimensional organization of the subventricular germinal zone in the adult mammalian brain.
    J Neurosci. 1997 Jul 1;17(13):5046-61 PMID: 9185542
  25. Medulloblastoma growth inhibition by hedgehog pathway blockade.
    Science. 2002 Aug 30;297(5586):1559-61 PMID: 12202832
  26. The developmental biology of brain tumors.
    Annu Rev Neurosci. 2001;24:385-428 PMID: 11283316
  27. Notch pathway inhibition depletes stem-like cells and blocks engraftment in embryonal brain tumors.
    Cancer Res. 2006 Aug 1;66(15):7445-52 PMID: 16885340
  28. Isolation of a candidate human hematopoietic stem-cell population.
    Proc Natl Acad Sci U S A. 1992 Apr 1;89(7):2804-8 PMID: 1372992
  29. Proliferating subventricular zone cells in the adult mammalian forebrain can differentiate into neurons and glia.
    Proc Natl Acad Sci U S A. 1993 Mar 1;90(5):2074-7 PMID: 8446631
  30. Notch signals control the fate of immature progenitor cells in the intestine.
    Nature. 2005 Jun 16;435(7044):964-8 PMID: 15959516
  31. Radial glia cells are candidate stem cells of ependymoma.
    Cancer Cell. 2005 Oct;8(4):323-35 PMID: 16226707
  32. Neural stem cells and the origin of gliomas.
    N Engl J Med. 2005 Aug 25;353(8):811-22 PMID: 16120861
  33. Identification of a cancer stem cell in human brain tumors.
    Cancer Res. 2003 Sep 15;63(18):5821-8 PMID: 14522905
  34. Identification of human brain tumour initiating cells.
    Nature. 2004 Nov 18;432(7015):396-401 PMID: 15549107
  35. Isolation and characterization of tumorigenic, stem-like neural precursors from human glioblastoma.
    Cancer Res. 2004 Oct 1;64(19):7011-21 PMID: 15466194
  36. Stem cell-like glioma cells promote tumor angiogenesis through vascular endothelial growth factor.
    Cancer Res. 2006 Aug 15;66(16):7843-8 PMID: 16912155
  37. Analysis of gene expression and chemoresistance of CD133+ cancer stem cells in glioblastoma.
    Mol Cancer. 2006 Dec 02;5:67 PMID: 17140455
  38. Stem cells, cancer, and cancer stem cells.
    Nature. 2001 Nov 1;414(6859):105-11 PMID: 11689955
  39. Neurogenesis in the subventricular zone and rostral migratory stream of the neonatal and adult primate forebrain.
    Exp Neurol. 2001 Nov;172(1):1-16 PMID: 11681836
  40. Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell.
    Nat Med. 1997 Jul;3(7):730-7 PMID: 9212098
  41. Gene therapy of experimental brain tumors using neural progenitor cells.
    Nat Med. 2000 Apr;6(4):447-50 PMID: 10742153
  42. Neurogenesis in adult subventricular zone.
    J Neurosci. 2002 Feb 1;22(3):629-34 PMID: 11826091
  43. Glioma stem cells promote radioresistance by preferential activation of the DNA damage response.
    Nature. 2006 Dec 7;444(7120):756-60 PMID: 17051156
  44. Wnt signalling in stem cells and cancer.
    Nature. 2005 Apr 14;434(7035):843-50 PMID: 15829953
  45. The multifaceted role of Notch in cancer.
    Curr Opin Genet Dev. 2007 Feb;17(1):52-9 PMID: 17178457
  46. Network of tangential pathways for neuronal migration in adult mammalian brain.
    Proc Natl Acad Sci U S A. 1996 Dec 10;93(25):14895-900 PMID: 8962152
  47. Integration of Notch and Wnt signaling in hematopoietic stem cell maintenance.
    Nat Immunol. 2005 Mar;6(3):314-22 PMID: 15665828
  48. Neuroblasts of the postnatal mammalian forebrain: their phenotype and fate.
    J Neurobiol. 1998 Aug;36(2):221-33 PMID: 9712306
  49. Prospective identification of tumorigenic breast cancer cells.
    Proc Natl Acad Sci U S A. 2003 Apr 1;100(7):3983-8 PMID: 12629218
  50. Unique astrocyte ribbon in adult human brain contains neural stem cells but lacks chain migration.
    Nature. 2004 Feb 19;427(6976):740-4 PMID: 14973487
  51. Regeneration of a germinal layer in the adult mammalian brain.
    Proc Natl Acad Sci U S A. 1999 Sep 28;96(20):11619-24 PMID: 10500226
  52. HEDGEHOG-GLI1 signaling regulates human glioma growth, cancer stem cell self-renewal, and tumorigenicity.
    Curr Biol. 2007 Jan 23;17 (2):165-72 PMID: 17196391
  53. Neurogenesis in the adult human hippocampus.
    Nat Med. 1998 Nov;4(11):1313-7 PMID: 9809557
  54. Identification and isolation of multipotential neural progenitor cells from the subcortical white matter of the adult human brain.
    Nat Med. 2003 Apr;9(4):439-47 PMID: 12627226
Article Info
Journal
Current neurology and neuroscience reports
Abbr.
Curr Neurol Neurosci Rep
ISSN
1528-4042
DOI
10.1007/s11910-007-0033-3
Published
2007-05-00
Pages
215-20
Language
English
Region
United States
NLM ID
100931790
Subset
IM
External Links
PubMed source DOI: 10.1007/s11910-007-0033-3 View journal details
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