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PMID: 16133352 Published · ppublish English Journal Article Review

The genome and the nucleus: a marriage made by evolution. Genome organisation and nuclear architecture.

Chromosoma ·Vol. 114 ·No. 4 ·2005-09-00 ·Pages 212-29

Foster HA, Bridger JM

Abstract

Genomes are housed within cell nuclei as individual chromosome territories. Nuclei contain several architectural structures that interact and influence the genome. In this review, we discuss how the genome may be organised within its nuclear environment with the position of chromosomes inside nuclei being either influenced by gene density or by chromosomes size. We compare interphase genome organisation in diverse species and reveal similarities and differences between evolutionary divergent organisms. Genome organisation is also discussed with relevance to regulation of gene expression, development and differentiation and asks whether large movements of whole chromosomes are really observed during differentiation. Literature and data describing alterations to genome organisation in disease are also discussed. Further, the nuclear structures that are involved in genome function are described, with reference to what happens to the genome when these structures contain protein from mutant genes as in the laminopathies.

MeSH Terms
Animals Cell Differentiation Cell Nucleus/genetics,ultrastructure Chromatin/genetics Chromosomes/genetics,ultrastructure Evolution, Molecular Genetic Diseases, Inborn/genetics Genome Humans Mammals
Chemicals
Chromatin
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Foster Helen A
Laboratory of Nuclear and Genomic Health, Cell and Chromosome Biology Group, Division of Biosciences, School of Health Sciences and Social Care, Brunel University, Uxbridge UB8 3PH, UK.
Bridger Joanna M
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Article Info
Journal
Chromosoma
Abbr.
Chromosoma
ISSN
0009-5915
DOI
10.1007/s00412-005-0016-6
Published
2005-09-00
Epub
2005-00-15
Pages
212-29
Language
English
Region
Austria
NLM ID
2985138R
Subset
IM
External Links
PubMed source DOI: 10.1007/s00412-005-0016-6 View journal details
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