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PMID: 15082916 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S. Review

Of mice and Myc: c-Myc and mammary tumorigenesis.

Journal of mammary gland biology and neoplasia ·Vol. 9 ·No. 1 ·2004-01-00 ·Pages 27-37

Jamerson MH, Johnson MD, Dickson RB

Abstract

The proto-oncogene c- myc is involved in regulating proliferation and apoptosis, and its deregulation via genomic and postgenomic mechanisms, contributes to the development and progression of multiple human cancers, including those of the breast. Deregulated expression of c-Myc also contributes to neoplastic transformation by altering cellular differentiation pathways and by facilitating mutagenesis through induction of genomic instability. Transgenic and gene-knockout mice are frequently utilized to resolve the mechanisms through which specific genes influence the development and progression of malignancies. In this review, we discuss how research findings obtained from various c- myc transgenic mammary tumor models help to improve our resolution of c-Myc's role both in tumorigenesis of the murine mammary gland and cancer of the human breast.

MeSH Terms
Animals Breast Neoplasms/genetics,physiopathology Cell Differentiation Cell Transformation, Neoplastic Disease Models, Animal Female Gene Expression Regulation, Neoplastic Genes, myc Humans Mammary Glands, Animal/cytology,pathology Mammary Neoplasms, Animal/genetics,physiopathology Mice Mice, Knockout Proto-Oncogene Mas Proto-Oncogene Proteins c-myc/pharmacology
Chemicals
MAS1 protein, human Myc protein, mouse Proto-Oncogene Mas Proto-Oncogene Proteins c-myc
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Jamerson M Hunter
Department of Oncology and Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC, USA.
Johnson Michael D
Dickson Robert B
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Article Info
Journal
Journal of mammary gland biology and neoplasia
Abbr.
J Mammary Gland Biol Neoplasia
ISSN
1083-3021
DOI
10.1023/B:JOMG.0000023586.69263.0b
Published
2004-01-00
Pages
27-37
Language
English
Region
United States
NLM ID
9601804
Subset
IM
Grants
NIA NIH HHS · 1R01AG1496 · United States
NCI NIH HHS · 1R01CA72460 · United States
External Links
PubMed source DOI: 10.1023/B:JOMG.0000023586.69263.0b View journal details
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