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PMID: 3014513 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Genetic alteration of the c-myc protooncogene (MYC) in human primary breast carcinomas.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 83 ·No. 13 ·1986-07-00 ·Pages 4834-8

Escot C, Theillet C, Lidereau R, Spyratos F, Champeme MH, Gest J, Callahan R

Abstract

We have studied the genomic organization of the c-myc locus (MYC) from 121 human primary breast carcinomas. Two types of alterations were observed: (i) the c-myc protooncogene appeared to be amplified 2- to 15-fold in 38 (32%) of the carcinoma DNAs and (ii) a non-germ-line c-myc-related fragment of variable size was detected in 5 primary breast carcinoma DNAs. With three exceptions, all the tumors containing a genetic alteration of the c-myc locus were invasive ductal carcinomas. A significant correlation (P less than 0.02) was observed between patients more than 50 years old and the presence of a genetically altered c-myc. Enhanced levels of c-myc RNA were observed in 10 of 14 breast carcinomas examined. The c-myc gene was genetically altered in 6 of these 10 tumors. The frequency with which the c-myc gene is altered and its correlation with age suggest that it may play a role in the development of breast carcinomas.

MeSH Terms
Adenofibroma/genetics,pathology Age Factors Breast Neoplasms/genetics,pathology Carcinoma/genetics,pathology Carcinoma, Intraductal, Noninfiltrating/genetics,pathology DNA, Neoplasm/genetics Female Gene Amplification Gene Expression Regulation Humans Male Proto-Oncogene Proteins/genetics Proto-Oncogenes Receptors, Estrogen/analysis
Chemicals
DNA, Neoplasm Proto-Oncogene Proteins Receptors, Estrogen
Authors & Affiliations
7 authors, click to expand affiliations / ORCID
Escot C
Theillet C
Lidereau R
Spyratos F
Champeme M H
Gest J
Callahan R
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29 references, click to expand
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.83.13.4834
Published
1986-07-00
Pages
4834-8
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC323837
Subset
IM
External Links
PubMed source DOI: 10.1073/pnas.83.13.4834 PMC Full Text View journal details
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