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PMID: 6961453 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Human c-myc onc gene is located on the region of chromosome 8 that is translocated in Burkitt lymphoma cells.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 79 ·No. 24 ·1982-12-00 ·Pages 7824-7

Dalla-Favera R, Bregni M, Erikson J, Patterson D, Gallo RC, Croce CM

Abstract

Human sequences related to the transforming gene (v-myc) of avian myelocytomatosis virus (MC29) are represented by at least one gene and several related sequences that may represent pseudogenes. By using a DNA probe that is specific for the complete gene (c-myc), different somatic cell hybrids possessing varying numbers of human chromosomes were analyzed by the Southern blotting technique. The results indicate that the human c-myc gene is located on chromosome 8. The analysis of hybrids between rodent cells and human Burkitt lymphoma cells, which carry a reciprocal translocation between chromosomes 8 and 14, allowed the mapping of the human c-myc gene on region (q24 leads to qter) of chromosome 8. This chromosomal region is translocated to either human chromosome 2, 14, or 22 in Burkitt lymphoma cells.

MeSH Terms
Burkitt Lymphoma/genetics Chromosome Mapping Chromosomes, Human, 6-12 and X Gene Expression Regulation Humans Oncogenes
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
Dalla-Favera R
Bregni M
Erikson J
Patterson D
Gallo R C
Croce C M
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30 references, click to expand
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.79.24.7824
Published
1982-12-00
Pages
7824-7
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC347441
Subset
IM
Grants
PHS HHS · C20810 · United States
NCI NIH HHS · CA10813 · United States
NCI NIH HHS · CA16685 · United States
External Links
PubMed source DOI: 10.1073/pnas.79.24.7824 PMC Full Text View journal details
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