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PMID: 6095109 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

The neu oncogene: an erb-B-related gene encoding a 185,000-Mr tumour antigen.

Nature ·Vol. 312 ·No. 5994 ·1984-00-00 ·Pages 513-6

Schechter AL, Stern DF, Vaidyanathan L, Decker SJ, Drebin JA, Greene MI, Weinberg RA

Abstract

A series of rat neuro/glioblastomas all contain the same transforming gene (neu) which induces synthesis of a tumour antigen of relative molecular mass (Mr) 185,000 (p185). The neu oncogene bears homology to erb-B and the tumour antigen, p185, is serologically related to the epidermal growth factor (EGF) receptor. The two proteins, EGF receptor and p185 appear to be distinct, as they coexist in nontransformed Rat-1 cells.

MeSH Terms

Animals Antigens, Neoplasm/genetics Cross Reactions ErbB Receptors Glioma/genetics,immunology Molecular Weight Neuroblastoma/genetics,immunology Oncogenes Rats Receptors, Cell Surface/genetics,immunology

Chemicals

Antigens, Neoplasm Receptors, Cell Surface ErbB Receptors

Authors & Affiliations

7 authors, click to expand affiliations / ORCID

Schechter A L

Stern D F

Vaidyanathan L

Decker S J

Drebin J A

Greene M I

Weinberg R A

Article Info

Journal

Nature

Abbr.

Nature

ISSN

0028-0836

DOI

10.1038/312513a0

Published

1984-00-00

Pages

513-6

Language

English

Region

England

NLM ID

0410462

Subset

Grants

NCI NIH HHS · CA26717 · United States

NCI NIH HHS · CA31649 · United States

NIGMS NIH HHS · GM13972 · United States

External Links

PubMed source DOI: 10.1038/312513a0 View journal details

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The neu oncogene: an erb-B-related gene encoding a 185,000-Mr tumour antigen.

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