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PMID: 11467449 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

Myc and mammary cancer: Myc is a downstream effector of the ErbB2 receptor tyrosine kinase.

Journal of mammary gland biology and neoplasia ·Vol. 6 ·No. 1 ·2001-01-00 ·Pages 141-50

Hynes NE, Lane HA

Abstract

The proto-oncogene c-myc encodes a transcription factor which plays a major role in the regulation of normal cellular proliferation and is aberrantly expressed in many breast tumors. In a normal cell Myc expression levels are tightly regulated being subject to many layers of control. Errantly expressed Myc collaborates with other oncogenes to promote transformation. In this review we will focus on the association between abnormal Myc expression and mammary cancer. In particular, we will discuss the role of Myc as a downstream effector of the ErbB2 receptor tyrosine kinase which is overexpressed and constitutively activate in many mammary tumors. The cooperation between Myc and ErbB2 in transformation will be discussed in relation to clinical studies on Myc in human cancer and with consideration of transgenic models of Myc-induced mammary cancer. Data from our laboratory will be presented showing that deregulated ErbB2 activity strongly stimulates cytoplasmic signaling pathways which in turn impinge on Myc at multiple levels causing its deregulated expression.

MeSH Terms
Animals Female Humans Mammary Neoplasms, Animal/metabolism Mice Mice, Transgenic Proto-Oncogene Mas Proto-Oncogene Proteins c-myc/physiology Receptor, ErbB-2/metabolism Signal Transduction/physiology
Chemicals
MAS1 protein, human Proto-Oncogene Mas Proto-Oncogene Proteins c-myc Receptor, ErbB-2
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Hynes N E
Friedrich Miescher Institute, Basel, Switzerland. hynes@fmi.ch
Lane H A
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Article Info
Journal
Journal of mammary gland biology and neoplasia
Abbr.
J Mammary Gland Biol Neoplasia
ISSN
1083-3021
DOI
10.1023/a:1009528918064
Email
hynes@fmi.ch
Published
2001-01-00
Pages
141-50
Language
English
Region
United States
NLM ID
9601804
Subset
IM
External Links
PubMed source DOI: 10.1023/a:1009528918064 View journal details
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