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PMID: 10880430 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

The ErbB signaling network: receptor heterodimerization in development and cancer.

The EMBO journal ·Vol. 19 ·No. 13 ·2000-07-03 ·Pages 3159-67

Olayioye MA, Neve RM, Lane HA, Hynes NE

Abstract

暂无摘要

MeSH Terms
Animals Breast Neoplasms/metabolism Dimerization Humans Ligands Receptor, ErbB-2/metabolism Signal Transduction
Chemicals
Ligands Receptor, ErbB-2
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Olayioye M A
Friedrich Miescher Institute, PO Box 2543, CH-4002 Basel, Switzerland.
Neve R M
Lane H A
Hynes N E
References (125)
125 references, click to expand
  1. p185HER2 monoclonal antibody has antiproliferative effects in vitro and sensitizes human breast tumor cells to tumor necrosis factor.
    Mol Cell Biol. 1989 Mar;9(3):1165-72 PMID: 2566907
  2. Changes in ErbB2 (her-2/neu), ErbB3, and ErbB4 during growth, differentiation, and apoptosis of normal rat mammary epithelial cells.
    J Histochem Cytochem. 2000 Jan;48(1):63-80 PMID: 10653587
  3. Synergistic interaction of p185c-neu and the EGF receptor leads to transformation of rodent fibroblasts.
    Cell. 1989 Jul 28;58(2):287-92 PMID: 2568888
  4. Single-chain antibody-mediated intracellular retention of ErbB-2 impairs Neu differentiation factor and epidermal growth factor signaling.
    Mol Cell Biol. 1995 Mar;15(3):1182-91 PMID: 7532277
  5. ErbB receptor-induced activation of stat transcription factors is mediated by Src tyrosine kinases.
    J Biol Chem. 1999 Jun 11;274(24):17209-18 PMID: 10358079
  6. Phase II study of receptor-enhanced chemosensitivity using recombinant humanized anti-p185HER2/neu monoclonal antibody plus cisplatin in patients with HER2/neu-overexpressing metastatic breast cancer refractory to chemotherapy treatment.
    J Clin Oncol. 1998 Aug;16(8):2659-71 PMID: 9704716
  7. Clinical and prognostic significance of the expression of the c-erbB-2 and c-erbB-3 oncoproteins in primary and metastatic malignant melanomas and breast carcinomas.
    Anticancer Res. 1997 Mar-Apr;17(2B):1319-30 PMID: 9137492
  8. Targeted disruption of mouse EGF receptor: effect of genetic background on mutant phenotype.
    Science. 1995 Jul 14;269(5221):230-4 PMID: 7618084
  9. Think globally, act locally: the making of a mouse mammary gland.
    Genes Dev. 1998 Feb 15;12(4):449-55 PMID: 9472013
  10. Growth regulation of human breast and ovarian tumor cells by heregulin: Evidence for the requirement of ErbB2 as a critical component in mediating heregulin responsiveness.
    Cancer Res. 1996 Mar 15;56(6):1457-65 PMID: 8640840
  11. Employment of the epidermal growth factor receptor in growth factor-independent signaling pathways.
    J Cell Biol. 1999 Aug 23;146(4):697-702 PMID: 10459005
  12. Neu differentiation factor activation of ErbB-3 and ErbB-4 is cell specific and displays a differential requirement for ErbB-2.
    Mol Cell Biol. 1995 Dec;15(12):6496-505 PMID: 8524214
  13. Neu and its ligands: from an oncogene to neural factors.
    Bioessays. 1993 Dec;15(12):815-24 PMID: 7908191
  14. Autophosphorylation sites on the epidermal growth factor receptor.
    Nature. 1984 Oct 4-10;311(5985):483-5 PMID: 6090945
  15. eps15, a novel tyrosine kinase substrate, exhibits transforming activity.
    Mol Cell Biol. 1993 Sep;13(9):5814-28 PMID: 7689153
  16. Heregulin-dependent regulation of HER2/neu oncogenic signaling by heterodimerization with HER3.
    EMBO J. 1995 Sep 1;14(17):4267-75 PMID: 7556068
  17. Distribution of mRNA for human epiregulin, a differentially expressed member of the epidermal growth factor family.
    Biochem J. 1997 Aug 15;326 ( Pt 1):69-75 PMID: 9337852
  18. ErbB2 is necessary for induction of carcinoma cell invasion by ErbB family receptor tyrosine kinases.
    J Cell Biol. 2000 Jan 24;148(2):385-97 PMID: 10648571
  19. The cellular response to neuregulins is governed by complex interactions of the erbB receptor family.
    Mol Cell Biol. 1995 Oct;15(10):5770-6 PMID: 7565730
  20. Hierarchy of binding sites for Grb2 and Shc on the epidermal growth factor receptor.
    Mol Cell Biol. 1994 Aug;14(8):5192-201 PMID: 7518560
  21. Characterization of a neuregulin-related gene, Don-1, that is highly expressed in restricted regions of the cerebellum and hippocampus.
    Mol Cell Biol. 1997 Jul;17(7):4007-14 PMID: 9199335
  22. Identification of a novel autophosphorylation site (P4) on the epidermal growth factor receptor.
    Biochem J. 1989 Sep 1;262(2):659-63 PMID: 2803273
  23. Severe neuropathies in mice with targeted mutations in the ErbB3 receptor.
    Nature. 1997 Oct 16;389(6652):725-30 PMID: 9338783
  24. The biology of erbB-2/neu/HER-2 and its role in cancer.
    Biochim Biophys Acta. 1994 Dec 30;1198(2-3):165-84 PMID: 7819273
  25. Phase II study of weekly intravenous recombinant humanized anti-p185HER2 monoclonal antibody in patients with HER2/neu-overexpressing metastatic breast cancer.
    J Clin Oncol. 1996 Mar;14(3):737-44 PMID: 8622019
  26. Tyrosines 1148 and 1173 of activated human epidermal growth factor receptors are binding sites of Shc in intact cells.
    J Biol Chem. 1994 Jul 15;269(28):18674-8 PMID: 8034616
  27. Identification of autophosphorylation sites of HER2/neu.
    Cell Growth Differ. 1990 Jan;1(1):3-7 PMID: 1706616
  28. Specificity within the EGF family/ErbB receptor family signaling network.
    Bioessays. 1998 Jan;20(1):41-8 PMID: 9504046
  29. Studies of the HER-2/neu proto-oncogene in human breast and ovarian cancer.
    Science. 1989 May 12;244(4905):707-12 PMID: 2470152
  30. Topographic analysis of human epidermal growth factor by monospecific antibodies and synthetic peptides.
    J Biochem. 1989 Jul;106(1):87-92 PMID: 2476432
  31. The relationship between human epidermal growth-like factor receptor expression and cellular transformation in NIH3T3 cells.
    J Biol Chem. 1996 Nov 29;271(48):30897-903 PMID: 8940074
  32. Effects of oncogenic ErbB2 on G1 cell cycle regulators in breast tumour cells.
    Oncogene. 2000 Mar 23;19(13):1647-56 PMID: 10763821
  33. Shc phosphotyrosine-binding domain dominantly interacts with epidermal growth factor receptors and mediates Ras activation in intact cells.
    Mol Endocrinol. 1998 Apr;12(4):536-43 PMID: 9544989
  34. Pathogenic poxviruses reveal viral strategies to exploit the ErbB signaling network.
    EMBO J. 1998 Oct 15;17(20):5948-63 PMID: 9774339
  35. Heparin-binding EGF-like growth factor interacts with mouse blastocysts independently of ErbB1: a possible role for heparan sulfate proteoglycans and ErbB4 in blastocyst implantation.
    Development. 1999 May;126(9):1997-2005 PMID: 10101133
  36. All autophosphorylation sites of epidermal growth factor (EGF) receptor and HER2/neu are located in their carboxyl-terminal tails. Identification of a novel site in EGF receptor.
    J Biol Chem. 1989 Jun 25;264(18):10667-71 PMID: 2543678
  37. Intracellular expression of single chain antibodies reverts ErbB-2 transformation.
    J Biol Chem. 1994 Sep 30;269(39):23931-6 PMID: 7929040
  38. Differential responses of human tumor cell lines to anti-p185HER2 monoclonal antibodies.
    Cancer Immunol Immunother. 1993 Sep;37(4):255-63 PMID: 8102322
  39. Ligand-induced ubiquitination of the epidermal growth factor receptor involves the interaction of the c-Cbl RING finger and UbcH7.
    J Biol Chem. 1999 Oct 29;274(44):31707-12 PMID: 10531381
  40. Interactions of Drosophila Cbl with epidermal growth factor receptors and role of Cbl in R7 photoreceptor cell development.
    Mol Cell Biol. 1997 Apr;17(4):2217-25 PMID: 9121472
  41. ErbB2 potentiates breast tumor proliferation through modulation of p27(Kip1)-Cdk2 complex formation: receptor overexpression does not determine growth dependency.
    Mol Cell Biol. 2000 May;20(9):3210-23 PMID: 10757805
  42. Intracellular expression of a single-chain antibody directed to the EGFR leads to growth inhibition of tumor cells.
    Oncogene. 1996 Jul 18;13(2):275-82 PMID: 8710366
  43. ErbB4 signaling in the mammary gland is required for lobuloalveolar development and Stat5 activation during lactation.
    J Cell Biol. 1999 Oct 4;147(1):77-88 PMID: 10508857
  44. Neuregulin-4: a novel growth factor that acts through the ErbB-4 receptor tyrosine kinase.
    Oncogene. 1999 Apr 29;18(17):2681-9 PMID: 10348342
  45. A strain-independent postnatal neurodegeneration in mice lacking the EGF receptor.
    EMBO J. 1998 Feb 2;17(3):719-31 PMID: 9450997
  46. Positive and negative tissue-specific signaling by a nematode epidermal growth factor receptor.
    Mol Biol Cell. 1997 May;8(5):779-93 PMID: 9168466
  47. Src phosphorylation of the epidermal growth factor receptor at novel sites mediates receptor interaction with Src and P85 alpha.
    J Biol Chem. 1995 Jun 30;270(26):15591-7 PMID: 7797556
  48. Sequential requirement of hepatocyte growth factor and neuregulin in the morphogenesis and differentiation of the mammary gland.
    J Cell Biol. 1995 Oct;131(1):215-26 PMID: 7559778
  49. Intracellular trafficking of epidermal growth factor family ligands is directly influenced by the pH sensitivity of the receptor/ligand interaction.
    J Biol Chem. 1995 Mar 3;270(9):4334-40 PMID: 7876195
  50. Rescue of the cardiac defect in ErbB2 mutant mice reveals essential roles of ErbB2 in peripheral nervous system development.
    Neuron. 1999 Jun;23(2):273-83 PMID: 10399934
  51. Membrane-anchored growth factors.
    Annu Rev Biochem. 1993;62:515-41 PMID: 8394682
  52. Signaling through the stromal epidermal growth factor receptor is necessary for mammary ductal development.
    Development. 1999 Jan;126(2):335-44 PMID: 9847247
  53. Expression of dominant-negative ErbB2 in the mammary gland of transgenic mice reveals a role in lobuloalveolar development and lactation.
    Oncogene. 1999 Jun 10;18(23):3481-90 PMID: 10376526
  54. The role of individual SH2 domains in mediating association of phospholipase C-gamma1 with the activated EGF receptor.
    J Biol Chem. 1999 Sep 10;274(37):26091-7 PMID: 10473558
  55. The let-23 gene necessary for Caenorhabditis elegans vulval induction encodes a tyrosine kinase of the EGF receptor subfamily.
    Nature. 1990 Dec 20-27;348(6303):693-9 PMID: 1979659
  56. Csk homologous kinase, a novel signaling molecule, directly associates with the activated ErbB-2 receptor in breast cancer cells and inhibits their proliferation.
    J Biol Chem. 1998 Feb 13;273(7):4065-72 PMID: 9461599
  57. Elevated expression of activated forms of Neu/ErbB-2 and ErbB-3 are involved in the induction of mammary tumors in transgenic mice: implications for human breast cancer.
    EMBO J. 1999 Apr 15;18(8):2149-64 PMID: 10205169
  58. A point mutation in the neu oncogene mimics ligand induction of receptor aggregation.
    Nature. 1989 May 18;339(6221):230-1 PMID: 2654648
  59. CDK inhibitors: positive and negative regulators of G1-phase progression.
    Genes Dev. 1999 Jun 15;13(12):1501-12 PMID: 10385618
  60. Multiple independent activations of the neu oncogene by a point mutation altering the transmembrane domain of p185.
    Cell. 1986 Jun 6;45(5):649-57 PMID: 2871941
  61. Requirement for neuregulin receptor erbB2 in neural and cardiac development.
    Nature. 1995 Nov 23;378(6555):394-8 PMID: 7477377
  62. Dimerization of cell surface receptors in signal transduction.
    Cell. 1995 Jan 27;80(2):213-23 PMID: 7834741
  63. Distinct tyrosine autophosphorylation sites negatively and positively modulate neu-mediated transformation.
    Mol Cell Biol. 1997 Sep;17(9):5410-25 PMID: 9271418
  64. Targeted expression of a dominant negative epidermal growth factor receptor in the mammary gland of transgenic mice inhibits pubertal mammary duct development.
    Mol Endocrinol. 1997 Nov;11(12):1766-81 PMID: 9369445
  65. Regulation of tyrosine kinase cascades by G-protein-coupled receptors.
    Curr Opin Cell Biol. 1999 Apr;11(2):177-83 PMID: 10209148
  66. Aberrant neural and cardiac development in mice lacking the ErbB4 neuregulin receptor.
    Nature. 1995 Nov 23;378(6555):390-4 PMID: 7477376
  67. The tyrosine kinase negative regulator c-Cbl as a RING-type, E2-dependent ubiquitin-protein ligase.
    Science. 1999 Oct 8;286(5438):309-12 PMID: 10514377
  68. Analysis of protein-protein interactions involved in the activation of the Shc/Grb-2 pathway by the ErbB-2 kinase.
    Oncogene. 1995 Oct 19;11(8):1519-29 PMID: 7478576
  69. Characterization of a naturally occurring ErbB4 isoform that does not bind or activate phosphatidyl inositol 3-kinase.
    Oncogene. 1999 Apr 22;18(16):2607-15 PMID: 10353604
  70. All ErbB receptors other than the epidermal growth factor receptor are endocytosis impaired.
    J Biol Chem. 1996 Mar 1;271(9):5251-7 PMID: 8617810
  71. Identification of c-erbB-3 binding sites for phosphatidylinositol 3'-kinase and SHC using an EGF receptor/c-erbB-3 chimera.
    EMBO J. 1994 Jun 15;13(12):2831-41 PMID: 8026468
  72. Glial-neuronal interactions in the neuroendocrine control of mammalian puberty: facilitatory effects of gonadal steroids.
    J Neurobiol. 1999 Sep 15;40(4):528-40 PMID: 10453054
  73. SH2 and PTB domain interactions in tyrosine kinase signal transduction.
    Curr Opin Chem Biol. 1997 Aug;1(2):227-34 PMID: 9667855
  74. Coupling of the c-Cbl protooncogene product to ErbB-1/EGF-receptor but not to other ErbB proteins.
    Oncogene. 1996 Mar 7;12(5):1117-25 PMID: 8649804
  75. Transformation of NIH 3T3 cells by HER3 or HER4 receptors requires the presence of HER1 or HER2.
    J Biol Chem. 1996 Feb 16;271(7):3884-90 PMID: 8632008
  76. Neuregulins with an Ig-like domain are essential for mouse myocardial and neuronal development.
    Proc Natl Acad Sci U S A. 1996 May 14;93(10):4833-8 PMID: 8643489
  77. Insect cell-expressed p180erbB3 possesses an impaired tyrosine kinase activity.
    Proc Natl Acad Sci U S A. 1994 Aug 16;91(17):8132-6 PMID: 8058768
  78. ErbB-1 and ErbB-2 acquire distinct signaling properties dependent upon their dimerization partner.
    Mol Cell Biol. 1998 Sep;18(9):5042-51 PMID: 9710588
  79. A hierarchical network of interreceptor interactions determines signal transduction by Neu differentiation factor/neuregulin and epidermal growth factor.
    Mol Cell Biol. 1996 Oct;16(10):5276-87 PMID: 8816440
  80. Structure-function relationships for the EGF/TGF-alpha family of mitogens.
    Growth Factors. 1994;11(4):235-57 PMID: 7779404
  81. ErbB-2 is a common auxiliary subunit of NDF and EGF receptors: implications for breast cancer.
    EMBO J. 1996 Jan 15;15(2):254-64 PMID: 8617201
  82. Expression of the type 1 tyrosine kinase growth factor receptors EGF receptor, c-erbB2 and c-erbB3 in bladder cancer.
    J Pathol. 1996 Aug;179(4):381-5 PMID: 8869284
  83. ErbB3 is required for normal cerebellar and cardiac development: a comparison with ErbB2-and heregulin-deficient mice.
    Development. 1997 Dec;124(24):4999-5011 PMID: 9362461
  84. A mutation in the epidermal growth factor receptor in waved-2 mice has a profound effect on receptor biochemistry that results in impaired lactation.
    Proc Natl Acad Sci U S A. 1995 Feb 28;92(5):1465-9 PMID: 7533293
  85. Two EGF molecules contribute additively to stabilization of the EGFR dimer.
    EMBO J. 1997 Jan 15;16(2):281-94 PMID: 9029149
  86. Switching signals on or off by receptor dimerization.
    Cell. 1998 Aug 7;94(3):277-80 PMID: 9708728
  87. Eps15 is recruited to the plasma membrane upon epidermal growth factor receptor activation and localizes to components of the endocytic pathway during receptor internalization.
    Mol Biol Cell. 1999 Feb;10(2):417-34 PMID: 9950686
  88. Similarity of sli-1, a regulator of vulval development in C. elegans, to the mammalian proto-oncogene c-cbl.
    Science. 1995 Aug 25;269(5227):1102-5 PMID: 7652556
  89. Multinational study of the efficacy and safety of humanized anti-HER2 monoclonal antibody in women who have HER2-overexpressing metastatic breast cancer that has progressed after chemotherapy for metastatic disease.
    J Clin Oncol. 1999 Sep;17(9):2639-48 PMID: 10561337
  90. Active signaling by Neu in transgenic mice.
    Oncogene. 1998 Oct 8;17(14):1877-84 PMID: 9778054
  91. c-Src phosphorylates epidermal growth factor receptor on tyrosine 845.
    Biochem Biophys Res Commun. 1995 Oct 24;215(3):1078-87 PMID: 7488034
  92. Epidermal growth factor receptors: critical mediators of multiple receptor pathways.
    Curr Opin Cell Biol. 1999 Apr;11(2):184-9 PMID: 10209149
  93. HER4-mediated biological and biochemical properties in NIH 3T3 cells. Evidence for HER1-HER4 heterodimers.
    J Biol Chem. 1996 Mar 1;271(9):4813-8 PMID: 8617750
  94. Grb2/Ash binds directly to tyrosines 1068 and 1086 and indirectly to tyrosine 1148 of activated human epidermal growth factor receptors in intact cells.
    J Biol Chem. 1994 Dec 9;269(49):31310-4 PMID: 7527043
  95. Ligands for ErbB-family receptors encoded by a neuregulin-like gene.
    Nature. 1997 May 29;387(6632):509-12 PMID: 9168114
  96. SH2 domains prevent tyrosine dephosphorylation of the EGF receptor: identification of Tyr992 as the high-affinity binding site for SH2 domains of phospholipase C gamma.
    EMBO J. 1992 Feb;11(2):559-67 PMID: 1537335
  97. ErbB-2, the preferred heterodimerization partner of all ErbB receptors, is a mediator of lateral signaling.
    EMBO J. 1997 Apr 1;16(7):1647-55 PMID: 9130710
  98. c-Src-mediated phosphorylation of the epidermal growth factor receptor on Tyr845 and Tyr1101 is associated with modulation of receptor function.
    J Biol Chem. 1999 Mar 19;274(12):8335-43 PMID: 10075741
  99. Bivalence of EGF-like ligands drives the ErbB signaling network.
    EMBO J. 1997 Aug 15;16(16):4938-50 PMID: 9305636
  100. The ErbB2 and ErbB3 receptors and their ligand, neuregulin-1, are essential for development of the sympathetic nervous system.
    Genes Dev. 1998 Jun 15;12(12):1825-36 PMID: 9637684
  101. Phosphotyrosine 1173 mediates binding of the protein-tyrosine phosphatase SHP-1 to the epidermal growth factor receptor and attenuation of receptor signaling.
    J Biol Chem. 1998 Sep 18;273(38):24839-46 PMID: 9733788
  102. Strain-dependent epithelial defects in mice lacking the EGF receptor.
    Science. 1995 Jul 14;269(5221):234-8 PMID: 7618085
  103. Analysis of Grb7 recruitment by heregulin-activated erbB receptors reveals a novel target selectivity for erbB3.
    J Biol Chem. 1998 Mar 27;273(13):7717-24 PMID: 9516479
  104. The role of autophosphorylation in modulation of erbB-2 transforming function.
    New Biol. 1990 Feb;2(2):187-95 PMID: 1982072
  105. Targeted inactivation of the EGF and amphiregulin genes reveals distinct roles for EGF receptor ligands in mouse mammary gland development.
    Development. 1999 Jun;126(12):2739-50 PMID: 10331984
  106. Multiple essential functions of neuregulin in development.
    Nature. 1995 Nov 23;378(6555):386-90 PMID: 7477375
  107. Binding specificities and affinities of egf domains for ErbB receptors.
    FEBS Lett. 1999 Mar 26;447(2-3):227-31 PMID: 10214951
  108. Neuregulin-3 (NRG3): a novel neural tissue-enriched protein that binds and activates ErbB4.
    Proc Natl Acad Sci U S A. 1997 Sep 2;94(18):9562-7 PMID: 9275162
  109. From Src Homology domains to other signaling modules: proposal of the 'protein recognition code'.
    Oncogene. 1998 Sep 17;17(11 Reviews):1469-74 PMID: 9779993
  110. Prognostic significance of HER2 and HER4 coexpression in childhood medulloblastoma.
    Cancer Res. 1997 Aug 1;57(15):3272-80 PMID: 9242460
  111. Epithelial immaturity and multiorgan failure in mice lacking epidermal growth factor receptor.
    Nature. 1995 Jul 27;376(6538):337-41 PMID: 7630400
  112. Betacellulin activates the epidermal growth factor receptor and erbB-4, and induces cellular response patterns distinct from those stimulated by epidermal growth factor or neuregulin-beta.
    Oncogene. 1996 Jan 18;12(2):345-53 PMID: 8570211
  113. Alternative intracellular routing of ErbB receptors may determine signaling potency.
    J Biol Chem. 1998 May 29;273(22):13819-27 PMID: 9593726
  114. Control of EGF receptor activation in Drosophila.
    Trends Cell Biol. 1997 Nov;7(11):431-6 PMID: 17709000
  115. The structural basis for the specificity of epidermal growth factor and heregulin binding.
    J Biol Chem. 1995 Apr 21;270(16):9585-9 PMID: 7721889
  116. Epidermal growth factor-related peptides and their receptors in human malignancies.
    Crit Rev Oncol Hematol. 1995 Jul;19(3):183-232 PMID: 7612182
  117. Ubiquitin ligase activity and tyrosine phosphorylation underlie suppression of growth factor signaling by c-Cbl/Sli-1.
    Mol Cell. 1999 Dec;4(6):1029-40 PMID: 10635327
  118. Epidermal growth factor-related peptides activate distinct subsets of ErbB receptors and differ in their biological activities.
    J Biol Chem. 1996 Mar 15;271(11):6071-6 PMID: 8626392
  119. Analysis of deletions of the carboxyl terminus of the epidermal growth factor receptor reveals self-phosphorylation at tyrosine 992 and enhanced in vivo tyrosine phosphorylation of cell substrates.
    J Biol Chem. 1990 Jan 25;265(3):1750-4 PMID: 1688559
  120. Dynamic expression and activation of ERBB receptors in the developing mouse mammary gland.
    Cell Growth Differ. 1998 Jun;9(6):451-64 PMID: 9663464
  121. Diversification of Neu differentiation factor and epidermal growth factor signaling by combinatorial receptor interactions.
    EMBO J. 1996 May 15;15(10):2452-67 PMID: 8665853
  122. Cooperative signaling of ErbB3 and ErbB2 in neoplastic transformation and human mammary carcinomas.
    Oncogene. 1995 May 4;10(9):1813-21 PMID: 7538656
  123. c-Src, receptor tyrosine kinases, and human cancer.
    Adv Cancer Res. 1999;76:61-119 PMID: 10218099
  124. Neuregulin-2, a new ligand of ErbB3/ErbB4-receptor tyrosine kinases.
    Nature. 1997 May 29;387(6632):512-6 PMID: 9168115
  125. Expression of the ERBB3 gene product in breast cancer.
    Br J Cancer. 1992 Dec;66(6):1116-21 PMID: 1333787
Article Info
Journal
The EMBO journal
Abbr.
EMBO J
ISSN
0261-4189
Published
2000-07-03
Pages
3159-67
Language
English
Region
England
NLM ID
8208664
PMCID
PMC313958
Subset
IM
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